The Centers of Biomedical Research Excellence (COBRE) support the establishment and development of innovative, state-of-the-art biomedical and behavioral research centers at institutions in IDeA-eligible states through awards for three sequential five-year phases.

The Fall 2025 open session of National Advisory General Medical Sciences Council includes the COBRE concept clearance. 

NIGMS has issued two COBRE-related forecasts:

Centers of Biomedical Research Excellence: Development Phase (COBRE-D)

Centers of Biomedical Research Excellence: Expansion/Sustainability Phases (COBRE E/S).

COBRE Post-Award Project Submission and Approval Guidelines​

COBRE Interactive Portfolio Dashboard​

COBRE RPPR Suggested Tables