NIGMS National and Regional Resources (R24) Program

The NIGMS National and Regional Resources (R24) Program supports resources that provide access to state-of-the-art facilities, equipment, technologies, research tools, software, and service to a substantial number of users on a national or multi-state regional basis to yield significant economies of scale in biomedical research. Resource capabilities and technologies should be sufficiently mature to require no major research and development efforts. The resource should provide routine service to a significant number of researchers, including the majority of investigators pursuing research areas within the mission of NIGMS. The resource is also expected to maintain current best practices, state-of-art technologies, defray operating expenses, provide user training, and publicize the services provided.

This program does not support new technology development. Prospective applicants with technologies requiring significant development may consider applying for the NIGMS Technology Development Programs. Prospective applicants with state-of-the-art technologies that have shown feasibility but are not yet sufficiently mature to provide general service may consider applying for the Biomedical Technology Development and Dissemination (RM1) Program. Prospective applicants with mature synchrotron technologies should apply through the NIGMS Mature Synchrotron Resources for Structural Biology (P30) Program.

The current Funding Opportunity Announcement is PAR-22-065​. Potential applicants are strongly encouraged to contact NIGMS staff at least 10 weeks prior to the application due date to determine the suitability of the proposed project for a NIGMS National and Regional Resource Program. An applicant requesting an annual budget equal to or over $500,000 is required to submit a Letter of Intent to NIGMS R24 Mailbox at least two weeks before application submission.

PDF Icon.Information for Current R24 Awardees: Guideline for Preparing your RPPR

Christina Liu, Ph.D. PE
Program Director
Division of Biophysics, Biomedical Technology, and Computational Biosciences
National Institute of General Medical Sciences
National Institutes of Health
45 Center Drive MSC 6200
Bethesda, MD 20892-6200

Biomedical National Elemental Imaging Resource (BNEIR)
Dartmouth College

R24 Grant Number: R24GM141194
Principal Investigator: Brian P. Jackson
The Biomedical National Elemental Imaging Resource (BNEIR), which will accelerate and simplify access for biomedical researchers to instrumentation, expertise, web-based and in-person training, after-visit support, software and will foster a dynamic community for elemental imaging users.

Dictyostelium Community Resource (DCR)
Northwestern University

R24 Grant Number: R24GM137770
Principal Investigator: Rex L. Chisholm​
The Dictyostelium Community Resource (DCR) is an integrated resource for investigators using Dictyostelium and related species for biomedical research and training. The DCR integrates two previously separately funded resources, dictyBase (R01GM064426), the model organism database and the Dicty Stock Center (R01GM087371), the strain and materials collection for Dictyostelids, to create a comprehensive community resource.

IDeA National Resource for Quantitative Proteomics
University of Arkansas for Medical Sciences

R24 Grant Number: R24GM137786
Principal Investigator: Alan Tackett
The IDeA National Resource for Quantitative Proteomics was created to: 1) Provide state-of-the-art quantitative proteomics services to the IDeA network, 2) Provide outreach opportunities for quantitative proteomics to the IDeA network, and 3) Provide educational opportunities for quantitative proteomics to the IDeA network. This Resource was previously supported by P20GM103429 and P20GM121293.

National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)
Cornell University

R24 Grant Number: R24-GM146107
Principal Investigators: Jack H. Freed, Ph.D. and Brian R. Crane, Ph.D.
National Resource for Advanced Electron-Spin Resonance Technologies (ACERT) provides an extensive range of modern ESR facilities for studying protein structure and function and protein and membrane dynamics using spin labeling techniques. This Resource was previously supported by the BTRR Program (P41GM103521).

National Glycoscience Resource-CCRC Service and Training
University of Georgia

R24 Grant Number: R24GM137782
Principal Investigator: Parastoo Azadi
The National Resource in Glycoscience that will offer service and hands-on training for compositional analysis and detailed structural characterization of all classes of glycoconjugates, including glycoproteins, polysaccharides, and glycolipids, to the greater scientific community. It was previously supported by the BTRR Program (P41GM103390 and P41GM103490).

National Center for Functional Glycomics (NCFG)
Harvard Medical School

R24 Grant Number: R24GM137763
Principal Investigator: Richard D. Cummings
The National Center for Functional Glycomics aims to enable researchers in the under-served area of glycosciences and whose research would benefit from glycoscience tools and expertise to provide continued and improved access to state-of-the-art technologies to advance biomedical research and human health involving protein-glycan interactions and glycan recognition. This Center was previously supported by the BTRR Program (P41GM103694).

National High-Throughput Crystallization Center (HTX)
Hauptman-Woodward Medical Research Institute

R24 Grant Number: R24GM141256
Principal Investigator: Sarah Elizabeth Johnson Bowman
The HTX National Crystallization Center provides unique protein crystallization services for structural biology to academic, government, and non-profit research institutes and industry. The automated crystallization system screens 1,536 crystallization conditions for each protein sample using the microbatch-under-oil method, monitors them with several imaging modalities over a period of six weeks and provides results through notifications, image sets and a final report. R24 grant support subsidizes access for non-profit organizations. This Resource was previously supported by R24GM124135.

National Resource for Mechanistic Modeling of Cellular Systems
University of Connecticut, School of Medicine

R24 Grant Number: R24GM137787
Principal Investigator: Leslie M. Loew
The National Resource for Mechanistic Modeling of Cellular Systems will provide computational modeling, enabled by COPASI and VCell technologies, will offer deep insights into mechanisms by which cells function and the cellular basis of disease. Projects by our user base focused on cancer, neurological disorders, diabetes, kidney disease, cardiology and aging, for example, all utilize mathematical models developed with the aid of VCell and COPASI. This Resource was previously supported by the BTRR Program (P41GM103313).

National User Resource for Biological Accelerator Mass Spectrometry (AMS)
Lawrence Livermore National Laboratory

R24 Grant Number: R24GM137748
Principal Investigator: Graham Bench
The National User Resource for Biological Accelerator Mass Spectrometry (AMS) provides ultra-high sensitivity, quantitative isotopic analysis for biomedical researchers measuring very low-level radioisotopes (primarily 14C). With over 30 years of expertise in the development and application of AMS for biomedical sciences under the BTRR Program (P41GM103483), the User Resource continues to enhance AMS analysis through utilization of new methods, instrumentation, and training for researchers.

NIGMS National and Regional Resources-DNASU
Arizona State University

R24 Grant Number: R24GM137776
Principal Investigator: Joshua Labaer
DNASU Plasmid Repository Resource is a non-profit, academic-based repository that provides academia, industry and the government with a wide variety of plasmids including specialized vectors, regulatory genetic sequences, and genes from 1,269 organisms, with many complete genome collections, including the first complete human set. This resource was previously supported by R24GM120465 and U01GM098912.

NMR User Program at the National Magnetic Resonance Facility at Madison (NMRFAM)
University of Wisconsin, Madison

R24 Grant Number: R24GM141526
Principal Investigator: Katherine A. Henzler-Wildman
NMRFAM is a unique resource for high-field NMR that leverages mature technologies for scientists, especially those who are not NMR experts, in order solve a wide range of biomedical research problems. NMRFAM has a well-earned reputation for community engagement, excellent service, world-class instruments and staff support that pro-active addresses user requirements. This Resource was previously supported by the BTRR Program (P41GM103399).

Phenix R24 Resource
Lawrence Berkeley National Laboratory

R24 Grant Number: R24GM141254
Principal Investigator: Paul David Adams
Phenix is a software suite that uses reduced data from X-ray diffraction, electron diffraction, neutron diffraction or cryo-EM 3D reconstructions to determine macromolecular structures. The Phenix Resource supports the continued maintenance and optimization of the Phenix code base, the improvements in program usability and integration with other community software resources, and the outreach, training and user support to help grow the community of Phenix users. This Resource was supported by P01GM063210.

Seattle Quant: A Resource for the Skyline Software Ecosystem
University of Washington

R24 Grant Number: R24GM141156
Principal Investigator: Michael Maccoss
Quantitative mass spectrometry measurements offer a promising alternative to immunological based assays that are the standard for quantitative protein measurements in clinical and basic research laboratories. Critical to these experiments is our software, Skyline and the associated ecosystem of tools, which have been developed to handle the generation of instrument methods and the subsequent analysis of the resulting data. This Resource was previously supported by the BTRR Program (P41GM103533).

The Genomic Enzymology Web-Based Resource
University of Illinois at Urbana-Champaign​

R24 Grant Number: ​R24GM141196
Principal Investigator: John Gerlt
The Genomic Enzymology Web-Based Resource integrates three tools to enable the discovery of novel proteins and metabolic pathways. The tool pipeline is comprised of three analysis steps: (1) generation of sequence similarity networks (SSNs) enabling the semi-automated reconstruction of high-quality protein families built around any protein sequence, (2) parallel exploration of the genome neighborhood of a protein family across a diverse set of input genomes to discover functionally linked gene products to infer novel enzymatic functions and metabolic pathways, and (3) determination of metagenome abundance of clusters in the SSNs to discover important targets for functional assignment. This resource was previously supported by U54GM093342 and P01GM118303.