The Protein Structure Initiative (PSI), which ended in July 2015, was a national effort to assemble a large collection of protein structures in a high-throughput operation. Knowledge gained could help researchers better understand the function of proteins, learn how altered structures can contribute to disease and identify new targets for drug development.
Goal: To use high-throughput methods developed during the PSI pilot phase for the production of a large number of unique protein structures and for the continued development of methods to improve the structural genomics pipeline; to remove bottlenecks to the protein expression, crystallization, production and structural determination of more challenging proteins, such as membrane proteins, small protein complexes and proteins from human and other higher eukaryotes.
Project period: July 2005 to June 2010
Total costs for 5 years: $325 million (funded largely by the National Institute of General Medical Sciences, with additional contributions from the former National Center for Research Resources)
Number of PSI-solved protein structures: 4,800 (as of August 2010)
Unique Structures (sharing less than 30 percent of their sequence with other known proteins): 4,100 (as of August 2010)
Read about other technologies being developed by the PSI centers on the technology portal of the PSI:Biology Structural Biology Knowledgebase.
For more information about the research centers, see the
large-scale centers RFA, the
specialized centers RFA and
frequently asked questions about them.
NIGMS supports basic biomedical research that is the foundation for advances in the diagnosis, treatment and prevention of disease. NIGMS is part of the National Institutes of Health, U.S. Department of Health and Human Services. To learn more about NIGMS, visit
Content revised July 2015
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