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These centers create critical, often unique technology and methods at the forefront of their respective fields and apply them to a broad range of basic, translational and clinical research. This occurs through a synergistic interaction of technical and biomedical expertise, both within the centers and in intensive collaborations with other leading laboratories.
The centers serve a unique purpose in the broad context of NIH-funded research. They represent a critical mass of technological and intellectual capacity with a strong focus on service and training for outside investigators, as well as providing access to and dissemination of technologies, methods and software. Their goal is to promote the widespread and routine application of the cutting-edge technologies they develop across the full spectrum from bench to bedside. The BTDD program does not include development of new technologies. These efforts can be supported through research project grants (R01 and R21 activity codes) targeted for technology development in areas of the NIGMS mission.
The BTDD (RM1) program replaces the Biomedical Technology Research Resources (P41) program.
Find out how to apply for funding:
Find a center with the capabilities you need on the BTR Portal Site (Note you are leaving the official NIGMS website).
Paul Sammak, Ph.D.BTDD Program DirectorNational Institute of General Medical SciencesNational Institutes of Health45 Center Drive MSC 6200Bethesda, MD 20892-6200
P41GM118217Principal Investigator: Rama Ranganathan, Ph.D., J. Keith Moffat, Ph.D., and Vukica Srajer, Ph.D.BioCARS is a state-of-the art, national user facility at the Advanced Photon Source, Argonne National Laboratory for synchrotron-based studies of the dynamic & static properties of macromolecules. Using X-ray scattering techniques such as time-resolved crystallography, small- & wide-angle X-ray scattering & fiber diffraction. BioCARS operates 2 X-ray beamlines, embedded in a Biosafety Level 2 (BSL-2) facility unique in the U.S. that permits safe studies of biohazardous materials such as human pathogens.
P41GM103622Principal Investigator: Thomas C. Irving, Ph.D.BioCAT operates facilities at Argonne National Laboratory’s Advanced Photon Source as a national research resource for the study of the structure of partially ordered biological molecules, complexes of biomolecules and cellular structures under conditions similar to those present in living cells and tissues.
P41GM111135Principal Investigator: Jeffrey C. Hoch, Ph.D.The Center for Bio-NMR Data Processing and Analysis develops robust methods to facilitate discovery, dissemination, management, training, and support for the biomolecular NMR software, to enable the application of NMR to biomolecular systems, and provide software persistence that is essential for reproducible research.
P41GM103484Principal Investigator: Pavel A. Pevzner, Ph.D., Vineet Bafna, Ph.D., and Nuno F. Cabrita, Ph.D.This center focuses on the computational bottlenecks that impair the interpretation of data, bringing modern algorithmic approaches to mass spectrometry and building a new generation of reliable, open-access software tools to support both new mass spectrometry instrumentation and emerging applications.
P41GM103545Principal Investigator: Christopher R. Johnson, Ph.D., Rob S. MacLeod, Ph.D., and Ross T. Whitaker, Ph.D.This resource produces open-source software tools for biomedical image-based modeling, biomedical simulation and estimation, and visualization of biomedical data.
P41GM135019Principal Investigator: Anne E. Carpenter, Ph.D. and Kevin W. Eliceiri, Ph.D.COBA will provide quantitative image analysis software tools that have broad applicability in biological optical microscopy. This effort will build on two widely used open source bioimage analysis programs, CellProfiler and ImageJ/FIJI, and add deep learning capability to enhance accuracy, ease-of-use, and reproducibility.
P41GM118302Principal Investigator: Arthur G. Palmer, Ph.D.The Center on Macromolecular Dynamics by NMR Spectroscopy (CoMD/NMR) is developing the technology and application of NMR spin relaxation and associated methods for characterizing protein and nucleic acid conformational dynamics in biological processes including ligand recognition, allosterism, catalysis, and folding.
P41GM116799Principal Investigator: Wayne A. Hendrickson, Ph.D.The Center on Membrane Protein Production and Analysis (COMPPÅ) is engaged in developing technologies for functional assays of membrane proteins, and advancing technology for the efficient production of recombinant membrane proteins for structural analysis and structure determination.
P41GM132087Principal Investigator: Norbert Perrimon, Ph.D.The DRSC-BTRR helps researchers realize the full potential of Drosophila melanogaster as a model for the study of human health and disease through development of technologies and community engagement, including (1) Development of technologies for Drosophila studies, (2) Application of technologies for study of mosquito vectors of human diseases, and (3) Development of in vivo proteomics technologies for Drosophila.
P41GM103490Principal Investigator: J. Michael Pierce, Ph.D.This resource is located at the Complex Carbohydrate Research Center and develops and implements new technologies to investigate the glycome of cells, including glycoproteomics and glycoconjugate analysis, transcript analysis, and bioinformatics.
P41GM103540Principal Investigator: Enrico Gratton, Ph.D.This resource develops novel fluorescence technologies, including instrumentation, methods and software. These are applicable to cellular imaging and the elucidation of dynamic processes in cells.
P41GM111244Principal Investigator: Sean McSweeney, Ph.D.This resource provides access to two advanced beam lines for macromolecular crystallography and one for general x-ray scattering studies, as well as smaller programs in macromolecular crystallography correlated with optical spectroscopy, and x-ray fluorescence imaging.
P41GM103485Principal Investigator: Richard A. Cerione, Ph.D.This resource operates two beamlines devoted to macromolecular crystallography and small-angle scattering at the Cornell High Energy Synchrotron Source (CHESS) and provides expertise in large unit-cell diffraction, MAD phasing, microdiffraction, high- pressure cryocooling, multiple beam diffraction and software development.
P41GM136508Principal Investigator: Tamir Gonen, Ph.D. and Pawel A. Penczek, Ph.D.MEDIC develops technologies for the study of the structure of nanocrystalline organic molecules & macromolecules by microcrystal electron diffraction (MicroED), & provides access & training. Research areas include: effective nanocrystal growth, screening & vitrification; phasing methods for MicroED for structure determination; effectively studying natural products, small molecules & toxins; & the engineering & fabrication of new hardware for nanocrystallization & time-resolved dynamics.
P41GM132079Principal Investigator: Robert G. Griffin, Ph.D.The MIT-Harvard Center for Magnetic Resonance develops new instrumentation for dynamic nuclear polarization experiments at high field, solid-state MAS NMR experiments to elucidate the structure of proteins, and advancing solution NMR experiments.
P41GM103521Principal Investigator: Jack H. Freed, Ph.D.This resource develops electron spin resonance technologies that are applicable to elucidating the structure and complex dynamics of proteins and to other biomedical applications.
P41GM109824Principal Investigator: Michael P. Rout, Ph.D.NCDIR combines expertise in cell biology, genetics, mass spectrometry and computational structural biology to develop new integrated approaches for the detection, isolation and analysis of macromolecular complexes that that make up the dynamic cellular interactome.
P41GM103694Principal Investigator: Richard D. Cummings, Ph.D.NCFG develops technologies in the glycosciences, with an emphasis on glycan microarray and glycan presentation for exploration of the molecular mechanisms of glycan recognition by proteins important in human biology and disease.
P41GM103832Principal Investigator: Wah Chiu, Ph.D.NCMI is focused on extending the resolution, speed and flexibility of cryo-electron microscopy for the 3-D structure determination of biological macromolecular assemblies. The center also develops cryo-electron tomography techniques to capture molecular structures in situ.
P41GM103712Principal Investigator: Ivet Bahar, Ph.D.MMBioS develops technology and tools to facilitate research and training at the interface between computing technology and the life sciences. The center also works to deepen understanding of the molecular and cellular organization and mechanisms that underlie synaptic signaling and regulation.
P41GM108538Principal Investigator: Joshua J. Coon, Ph.D.The National Center for Quantitative Biology of Complex Systems (NCQBCS) is developing next-generation protein, metabolite, and lipid measurement technologies for a wide variety of biomedical applications and making whole omic analysis faster and broadly accessible.
P41GM103445Principal Investigator: Carolyn A. Larabell, Ph.D.NCXT develops soft X-ray tomography for visualizing and quantifying the internal structure of whole, hydrated cells and high-numerical aperture fluorescence microscopy for locating the position of specific cellular molecules.
P41GM103399Principal Investigator: John L. Markley, Ph.D. and Samuel E. Butcher, Ph.D.This resource develops NMR technologies for the high-throughput structure determination of small proteins and RNA, for elucidating the structure and dynamics of complex systems, and for metabolomics.
P41GM103391Principal Investigator: Richard M. Caprioli, Ph.D.The mission of this resource is to advance the technology of imaging mass spectrometry, to facilitate the application of this novel imaging modality to problems of biological and clinical significance, and to promote the adoption of these technologies by a larger community of scientists and clinicians.
P41GM122698Principal Investigator: Timothy Cross, Ph.D., William W. Brey, Ph. D., and Joanna R. Long, Ph. D.The National Resource for Advancing NMR Technology is developing technologies to increase the sensitivity and spectral resolution of NMR spectroscopy, with a focus on instrumentation development.
P41GM103310Principal Investigator: Bridget O. Carragher, Ph.D. and Clinton S. PotterNRAMM develops, tests and applies technology aimed toward completely automating the processes involved in solving macromolecular structures using cryo-electron microscopy. The goal is to establish a resource that will serve as a center for high-throughput molecular microscopy as well as for transferring this technique to the research community.
P41GM103504Principal Investigator: Trey Ideker, Ph.D.NRNB provides a freely available, open-source suite of software technology that broadly enables network-based visualization, analysis and biomedical discovery for NIH-funded researchers.
P41GM108569Principal Investigator: Neil L. Kelleher, Ph.D.The National Resource for Translational and Developmental Proteomics (NRTDP) is dedicated to accelerating a significant shift in how protein molecules are analyzed by mass spectrometrywith a focus on intact protein measurements.
P41GM103493Principal Investigator: Richard D. Smith, Ph.D.This resource develops and integrates new proteomic technologies for use in biomedical research, with an emphasis on high-resolution, quantitative approaches.
P41GM103390Principal Investigator: Kelley Moremen, Ph.D.This resource develops technologies to increase understanding of the molecular basis of protein-carbohydrate interactions in disease. The resource combines complementary technologies: synthetic chemistry, nuclear magnetic resonance, mass spectrometry, computational biology, protein expression and cell-based assays.
P41GM104601Principal Investigator: Emad Tajkhorshid, Ph.D.This resource’s technology research and development activities focus on the structure and function of supramolecular systems in the living cell as well as on the development of new algorithms and efficient computing tools for physical biology. The development and maintenance of widely distributed software tools, nanoscale molecular dynamics and visual molecular dynamics are central to this work.
P41GM128577Principal Investigator: Vicki H. Wysocki, Ph.D.The Resource for Native MS-Guided Structural Biology is building an integrated MS-based workflow for intact, native complexes, i.e. “complex-down” characterization, with innovative scientific instrumentation and computational tools to reveal the complex chemical structures of biomedically relevant molecules.
P41GM103393Principal Investigator: Keith O. Hodgson, Ph.D.SSRL is an integrated resource with macromolecular crystallography, X-ray absorption spectroscopy and small-angle X-ray scattering/diffraction services.
P41GM103422Principal Investigator: Michael L. Gross, Ph.D.This resource develops mass spectrometry-based tools for the study of proteins, lipids and metaboilites. These include biomarker identification, stable isotope mass spectrometry and the analysis of intact proteins.
P41GM103533Principal Investigator: Michael MacCoss, Ph.D.The Yeast Resource Center (YRC) has a focus on understanding how genome sequence relates to protein function by studying how variation in proteins affects their levels, modification, function and structure. New technologies are being developed in three areas: 1) Perturbing and sensing changes to complex pathways; 2) Protein detection and quantitation by mass spectrometry; and 3) Higher order protein structure.
Dr. Mary Ann Wu
Health Scientist AdministratorDivision of Biophysics, Biomedical Technology, and Computational BiosciencesNational Institute of General Medical SciencesNational Institutes of Health45 Center Drive MSC 6200Bethesda, MD 20892-6200
This page last reviewed on
6/30/2020 11:24 AM
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