National Institute of
General Medical Sciences

Features
Protein Paradox [PDF 10.2MB]
The Science of Size [PDF 10.2MB]
Articles
A World Without Pain [PDF 10.2MB]
Demystifying General Anesthetics [PDF 10.2MB]
There's an "Ome" for That [PDF 10.2MB]
Lighting Up the Promise of Gene Therapy for Glaucoma [PDF 10.2MB]
NIGMS Is on Instagram! [PDF 10.2MB]
Departments
Cool Tools: High-Resolution Microscopy—In Living Color [PDF 10.2MB]
Spotlight on Videos: Scientists in Action [PDF 10.2MB]
Spotlight on the Cell: The Extracellular Matrix, a Multitasking Marvel [PDF 10.2MB]
Activities
Superstars of Science Quiz [PDF 10.2MB]
The Last Word [PDF 214KB]

Up Close With: Alfred Atanda Jr. [PDF 4.4MB]
Game Changer: Studying Sports Injuries in Kids [PDF 4.4MB]
Spotlights on Hot Science
Just Found: Say Cheese [PDF 4.4MB]
Just Found: Training Cells to Devour Dying Neighbors [PDF 4.4MB]
On the Trail of Drug-Defying Superbugs [PDF 4.4MB]
Capitalizing on Cellular Conversations [PDF 4.4MB]
Spotlight on Videos: The Rise and Fall of Microtubules, Bleach vs. Bacteria [PDF 4.4MB]
Knowing Networks [PDF 4.4MB]
Where in the Body? [PDF 4.4MB]

Up Close With: Emily Scott [PDF 2.7MB]
Hooked on Heme: Examining Enzymes and Cancer's Causes [PDF 2.7MB]
Spotlights on Hot Science
Just Found: How Bacterial Slime Clogs the Works [PDF 2.7MB]
Just Found: Mysterious, Rare Blood Type Explained [PDF 2.7MB]
How Porcupines and Geckos Inspire Medical Materials [PDF 2.7MB]
Learning About Human Biology From a Fish [PDF 2.7MB]
Mitochondrial Mix-Up [PDF 2.7MB]
Spotlighting the Ballet of Mitosis [PDF 2.7MB]
Where in the Body? [PDF 2.7MB]

Up Close With: Brad Duerstock [PDF 17.1MB]
Opening Up the Lab: Improving Access to Science for People with Disabilities [PDF 17.1MB]
DO-IT for Science [PDF 17.1MB]
Spotlights on Hot Science
Just Found: Does Cholesterol Play a Role in Alzheimer's? [PDF 17.1MB]
Just Found: How Bacteria Defend Themselves Against Fluoride [PDF 17.1MB]
Five Foul Things That Are Also Good for You [PDF 17.1MB]
Chromosomal Caps in Sickness and in Health [PDF 17.1MB]
Cellular Stress Relievers [PDF 17.1MB]
Cilia: Biology's Brooms [PDF 17.1MB]
The Last Word [PDF 17.1MB]

Up Close With: Elizabeth Grice [PDF 3.2MB]
Body Bacteria: Exploring the Skin's Microbial Metropolis [PDF 3.2MB]
Belly Button Bacteria [PDF 3.2MB]
Spotlights on Hot Science
Just Found: Making Heads or Tails of Regeneration [PDF 3.2MB]
Just Found: Microscopic Mood Rings [PDF 3.2MB]
Drakes: A Mythological Model Organism [PDF 3.2MB]
The Amazing World Inside a Human Cell [PDF 3.2MB]
Solving the Sleeping Sickness 'Mystery' [PDF 3.2MB]
Walking the Line [PDF 3.2MB]
Spot the Difference [PDF 3.2MB]

Up Close With: George Hightower [PDF 3.2MB]
HIV on the Brain [PDF 3.2MB]
DNA Sequences Expose Fishy Sushi [PDF 3.2MB]
Up Close With: Cara Altimus [PDF 3.2MB]
A Light on Life's Rhythms [PDF 3.2MB]
How the Body Keeps Track of Time—Or Doesn't [PDF 3.2MB]
Just Found
A Sweet Solution for Detecting Cholera [PDF 3.2MB]
Breathing Easy: Inflammation Under Control [PDF 3.2MB]
Got Guts? [PDF 3.2MB]
Starved Parents, Obese Children? [PDF 3.2MB]
The Last Word [PDF 3.2MB]

Up Close With: Brian Bachmann [PDF 3.4MB]
Drugs from Deep Down [PDF 3.4MB]
A Born Chemist [PDF 3.4MB]
Up Close With: Amy Palmer [PDF 3.4MB]
Mesmerized by Metals [PDF 3.4MB]
Metal Match [PDF 3.4MB]
Just Found
Breaking Up Biofilms Is Hard to Do [PDF 3.4MB]
Cells for Sight [PDF 3.4MB]
Seeking the Causes of Sepsis [PDF 3.4MB]
Sun Damage—More Than Skin Deep [PDF 3.4MB]
The Last Word [PDF 3.4MB]

Up Close With: Estela Arrese [PDF 3.25MB]
Fruitful Work [PDF 3.25MB]
Up Close With: Kevin Tracey [PDF 3.25MB]
For Janice: Legacy of a Short Life [PDF 3.25MB]
Cytokine Theory of Disease [PDF 3.25MB]
Just Found
A New Layer of Bacterial Defense [PDF 3.25MB]
Tylenol® as Lifesaver? [PDF 3.25MB]
A New View of the Flu [PDF 3.25MB]
Rx: Genome Sequence [PDF 3.25MB]
The Last Word [PDF 3.25MB]

Up Close With: Gary Churchill [PDF 1.66MB]
Mountains and Mouse Genes [PDF 1.66MB]
Medical Mice [PDF 1.66MB]
Up Close With: Julie Johnson [PDF 1.66MB]
The Right Fit [PDF 1.66MB]
Genes, Disease and Drugs [PDF 1.66MB]
Just Found
The Bad Side of a Good Drug [PDF 1.66MB]
Contact Medicine [PDF 1.66MB]
Naturally Curly [PDF 1.66MB]
Facebook Tracks Swine Flu Reaction [PDF 1.66MB]
The Last Word [PDF 1.66MB]

Up Close With: Marc Zimmer [PDF 9.48MB]
Green Light [PDF 9.48MB]
The Oscars of Chemistry [PDF 9.48MB]
Up Close With: Lola Eniola-Adefoso [PDF 9.48MB]
Special Delivery [PDF 9.48MB]
Making a MARC [PDF 9.48MB]
Just Found
Cancer Therapy's Got Rhythm [PDF 9.48MB]
Why Sleep? [PDF 9.48MB]
Algae Clean Up Arsenic [PDF 9.48MB]
Reading DNA Like a Book [PDF 9.48MB]
The Last Word [PDF 9.48MB]

Up Close With: Sarah Tishkoff [PDF 3.7MB]
Genetic Footprints [PDF 3.7MB]
The Big Family Tree [PDF 3.7MB]
Up Close With: Joe Thornton [PDF 3.7MB]
Past to Present [PDF 3.7MB]
Joe the Scientist [PDF 3.7MB]
Just Found
Chimp Changes [PDF 3.7MB]
Mystery Malaria [PDF 3.7MB]
Bugs On Us [PDF 3.7MB]
Lifestyle Effects [PDF 3.7MB]

Up Close With: Erik Sorensen [PDF 2MB]
Mimicking Mother Nature [PDF 2MB]
Bioprospecting: Finding a Balance [PDF 2MB]
Up Close With: Cynthia McMurray [PDF 2MB]
Living With Huntington's [PDF 2MB]
What's Your Genetic Destiny? [PDF 2MB]
Just Found
Shrew-ed Science [PDF 2MB]
Garlic: To Your Health! [PDF 2MB]
Feeling Cancer [PDF 2MB]
Corn Gets an A [PDF 2MB]
Fix for a Broken Heart? [PDF 2MB]
The Last Word [PDF 2MB]

Atul Butte: Dr. Data [PDF 1.38MB]
How You Can Be a Bioinformatician [PDF 1.38MB]
Peggy Goodell: Mastering Stem Cells [PDF 1.38MB]
Dual Doctors [PDF 1.38MB]
Just Found
What's in Your Mouth? [PDF 1.38MB]
Chemists Smell Dirt [PDF 1.38MB]
Molecule Memories [PDF 1.38MB]
Does Flu Fly South? [PDF 1.38MB]
Rapid "Ribo" Readout [PDF 1.38MB]
The Last Word [PDF 1.38MB]

Luisa Ann DiPietro: Healthy Healing [PDF 1.49MB]
A Balancing Act [PDF 1.49MB]
Stephen Eubank: Social Studies [PDF 1.49MB]
Spreading the Word [PDF 1.49MB]
Just Found
Overworked Gene Repair Kit Tied to Huntington's [PDF 1.49MB]
Gamers for Science [PDF 1.49MB]
Bacteria Make Strong Stitches [PDF 1.49MB]
Dandruff-Shampoo Ingredient May Calm Seizures [PDF 1.49MB]
Asthma Linked to Disappearing Stomach Bug [PDF 1.49MB]
The Last Word [PDF 1.49MB]

Drew Endy: Do-It-Yourself Biology [PDF 1.39MB]
Science and Society [PDF 1.39MB]
Cynthia Otto: Dogging Sepsis [PDF 1.39MB]
A Rare Breed [PDF 1.39MB]
Bench to Bedside
Traumatized T Cells [PDF 1.39MB]
Resisting AIDS Resistance [PDF 1.39MB]
Worm Sperm Illuminate Male Infertility [PDF 1.39MB]
Protein Linked to Cleft Lip and Palate [PDF 1.39MB]
Will Fight for Food [PDF 1.39MB]
The Last Word [PDF 1.39MB]

Chiara Cirelli: Recipe for Sleep [PDF 1.1MB]
Taste Tests [PDF 1.1MB]
Yuri Lazebnik: Hunting a Killer [PDF 1.1MB]
Killing Cancer With Aikido [PDF 1.1MB]
Bench to Bedside
Frogs Fighting Cancer [PDF 1.1MB]
Marking Multiple Sclerosis [PDF 1.1MB]
Vitamin B12 Explained [PDF 1.1MB]
Genes Affect Breast Cancer Drug Benefit [PDF 1.1MB]
Setting Standards [PDF 1.1MB]
The Last Word [PDF 1.1MB]

Neil Kelleher: The Humpty Dumpty Dilemma [PDF 1.18MB]
"Sprechen Sie Deutsch?"" [PDF 1.18MB]
Mavis Agbandje-McKenna: Viral Voyages [PDF 1.18MB]
Poultry, People, and a Possible Pandemic [PDF 1.18MB]
Bench to Bedside
Sticky Bones [PDF 1.18MB]
Forget the Surgery? [PDF 1.18MB]
Chicken Medicine [PDF 1.18MB]
Cancer Drug Fights Early Aging Disease [PDF 1.18MB]
Heart Alert [PDF 1.18MB]
The Last Word [PDF 1.18MB]

Dyann Wirth: Science Without Boarders [PDF 1.1MB]
The MIDAS Touch [PDF 1.1MB]
David Baker: The Family Business [PDF 1.1MB]
The Next Generation [PDF 1.1MB]
Bench to Bedside
A World Without Pain [PDF 1.1MB]
Making Sense of It ALL [PDF 1.1MB]
Ginseng's Many Moods [PDF 1.1MB]
Genes Help Treat Trauma [PDF 1.1MB]
Stressed Out DNA [PDF 1.1MB]
The Last Word [PDF 1.1MB]

Andrés Garcia: The Forces That Bind [PDF 632KB]
Forces Are With You [PDF 632KB]
Hilary Godwin: Getting the Lead Out [PDF 632KB]
Healthy Metals [PDF 632KB]
Bench to Bedside
Needle-Free Injections [PDF 632KB]
Finding a Single Microbe [PDF 632KB]
Seeing Red [PDF 632KB]
Bone Marrow Powers Wound Healing [PDF 632KB]
Wild Ox vs. Mosquito [PDF 632KB]
The Last Word [PDF 632KB]

Bonnie Bassler: Bugging the Bugs [PDF 2.4MB]
Squid Row [PDF 2.4MB]
Ram Sasisekharan: Life is Sweet [PDF 2.4MB]
Carbs Made Simple [PDF 2.4MB]
Bench to Bedside
Spice Therapy? [PDF 2.4MB]
Hot Flash News Flash [PDF 2.4MB]
From Hepatitis to Anthrax [PDF 2.4MB]
Blocking Bacteria [PDF 2.4MB]
Reconstructing a Deadly Flu [PDF 2.4MB]
The Last Word [PDF 2.4MB]

Gene Robinson: A Sting of Love [PDF 753KB]
It's About Time [PDF 753KB]
Serrine Lau: Chemical World [PDF 753KB]
The Weakest Link [PDF 753KB]
Bench to Bedside
Heard It From a Fly [PDF 753KB]
Botulinum Toxin Vaccine [PDF 753KB]
Tracking a Food-Borne Killer [PDF 753KB]
Blasting Cancer [PDF 753KB]
Basic Studies Yield Myeloma Drug [PDF 753KB]
The Last Word [PDF 753KB]

Maggie Werner-Washburne: A Perfect Mix [PDF 799KB]
A Pioneering Spirit [PDF 799KB]
Daniel Sessler: Asking Good Questions [PDF 799KB]
Bias Be Gone! [PDF 799KB]
Bench to Bedside
In a Heartbeat [PDF 799KB]
Natural De-Icer [PDF 799KB]
A Breath of Fresh Air [PDF 799KB]
Stuck on Mom [PDF 799KB]
PC, M.D.? [PDF 799KB]
The Last Word [PDF 799KB]

Brad Goodner: Planting Seeds [PDF 3.9MB]
Junior Explorers [PDF 3.9MB]
Dorothee Kern: Enzymes, Magnets, Action! [PDF 3.9MB]
Magnetic Attraction [PDF 3.9MB]
Bench to Bedside
Ironing Out Illness [PDF 3.9MB]
Finding a Cancer Drug's Mistakes [PDF 3.9MB]
Vitamin C Improves Skin Grafts [PDF 3.9MB]
Living Cleansers [PDF 3.9MB]
Cocaine Busted [PDF 3.9MB]
The Last Word [PDF 3.9MB]

Baldomero Olivera: Secrets of the Killer Snails [PDF 7.8MB]
Deadly Treasures [PDF 7.8MB]
Elaine Bearer: Cells in Motion [PDF 7.8MB]
Mountain Medicine [PDF 7.8MB]
Bench to Bedside
Cells' Sugar Coating Zaps Cancer [PDF 7.8MB]
Do the Math [PDF 7.8MB]
The Side Effects of a Misspelling [PDF 7.8MB]
Natural Bacterial Shield Protects the Body [PDF 7.8MB]
Stop Cell Death, Help Treat Sepsis? [PDF 7.8MB]
The Last Word [PDF 7.8MB]

Terry Gaasterland: Taking a Byte Out of Biology [PDF 923KB]
Biology + Computers = ? [PDF 923KB]
Hobart Harris: A Chance Discovery [PDF 923KB]
A Lucky Horseshoe [PDF 923KB]
Bench To Bedside
Heart Drug Prevents Muscle Loss After Burns [PDF 923KB]
Fruit Flies for Health [PDF 923KB]
Sour Orange Juice Gives Medicines An Extra Punch [PDF 923KB]
Fingerprinting Anthrax [PDF 923KB]
How Feverfew Works [PDF 923KB]
The Last Word [PDF 923KB]

Geoffrey Chang: Crystals for a Cure [PDF 8.3MB]
The Withering of "Miracle Cures" [PDF 8.3MB]
Angelika Amon: A Great Divide [PDF 8.3MB]
Sex and the Cell Cycle [PDF 8.3MB]
Bench To Bedside
Old Drugs Learn New Tricks [PDF 8.3MB]
Post-Trauma Infection is More Common in Men [PDF 8.3MB]
Exhausted T-Cells Spell Trouble in Arthritis [PDF 8.3MB]
Artificial Placenta May Help Test Drugs During Pregnancy [PDF 8.3MB]
New Test Uncovers Lupus [PDF 8.3MB]
The Last Word [PDF 8.3MB]

Alejandro Sánchez Alvarado: The Worm Returns [PDF 4.1MB]
Just Add Water [PDF 4.1MB]
Laura Kiessling: Sticky Situations [PDF 4.1MB]
Genius at Work [PDF 4.1MB]
Bench To Bedside
Cancer Patients Breathe Easier After This Test [PDF 4.1MB]
Souped-Up Artificial Skin Heals Burn Wounds [PDF 4.1MB]
A Little Fish WithYour Aspirin? [PDF 4.1MB]
Bacterial Slime a Hallmark of Cystic Fibrosis Lungs [PDF 4.1MB]
Seeing Clearly Now [PDF 4.1MB]
The Last Word [PDF 4.1MB]