National Institute of
Switch to Gallery View
Image and Video Gallery
This is a searchable collection of scientific photos, illustrations, and videos. The images and videos in this gallery are licensed under Creative Commons Attribution Non-Commercial ShareAlike 3.0. This license lets you remix, tweak, and build upon this work non-commercially, as long as you credit and license your new creations under identical terms.
Map of protein structures 02
2367
A global "map of the protein structure universe" indicating the positions of specific proteins. Berkeley Structural Genomics Center, PSI View Media
Secreted protein from Mycobacteria
2379
Model of a major secreted protein of unknown function, which is only found in mycobacteria, the class of bacteria that causes tuberculosis. Mycobacterium Tuberculosis Center, PSI View Media
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 2
3414
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media
Precise development in the fruit fly embryo
2593
This 2-hour-old fly embryo already has a blueprint for its formation, and the process for following it is so precise that the difference of just a few key molecules can change the plans. Thomas Gregor, Princeton University View Media
Structure of a key antigen protein involved with Hepatitis C Virus infection
5866
A three-dimensional representation of the structure of E2, a key antigen protein involved with hepatitis C virus infection. Mansun Law Associate Professor Department of Immunolgy and Microbial Science The Scripps Research Institute View Media
Assembly of the HIV capsid
5729
The HIV capsid is a pear-shaped structure that is made of proteins the virus needs to mature and become infective. John Grime and Gregory Voth, The University of Chicago View Media
PSI: from genes to structures
2363
The goal of the Protein Structure Initiative (PSI) is to determine the three-dimensional shapes of a wide range of proteins by solving the structures of representative members of each protein family f National Institute of General Medical Sciences View Media
Rabbit GPDA
2405
A crystal of rabbit GPDA protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Beta-galactosidase montage showing cryo-EM improvement--gradient background
5883
Composite image of beta-galactosidase showing how cryo-EM’s resolution has improved dramatically in recent years. Older images to the left, more recent to the right. Veronica Falconieri, Sriram Subramaniam Lab, National Cancer Institute View Media
Zinc finger
2426
The structure of a gene-regulating zinc finger protein bound to DNA. Jeremy M. Berg, National Institute of General Medical Sciences View Media
Himastatin, 360-degree view
6851
A 360-degree view of the molecule himastatin, which was first isolated from the bacterium Streptomyces himastatinicus. Himastatin shows antibiotic activity. Mohammad Movassaghi, Massachusetts Institute of Technology. View Media
PanB from M. tuberculosis (1)
2380
Model of an enzyme, PanB, from Mycobacterium tuberculosis, the bacterium that causes most cases of tuberculosis. This enzyme is an attractive drug target. Mycobacterium Tuberculosis Center, PSI View Media
Group of fluorescent C. elegans showing muscle and ribosomal protein
6582
Three C. elegans, tiny roundworms, with a ribosomal protein glowing red and muscle fibers glowing green. Researchers used these worms to study a molecular pathway that affects aging. Jarod Rollins, Mount Desert Island Biological Laboratory. View Media
Cell curvature
2803
Rendering of the surface of an endothelial cell; membrane curvature is color coded. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View Media
Cellular aging
2578
A protein called tubulin (green) accumulates in the center of a nucleus (outlined in pink) from an aging cell. Maximiliano D'Angelo and Martin Hetzer, Salk Institute View Media
Bacteriophage P22 capsid
5874
Cryo-electron microscopy (cryo-EM) has the power to capture details of proteins and other small biological structures at the molecular level. This image shows proteins in the capsid, or outer co Dr. Wah Chiu, Baylor College of Medicine View Media
SARS-CoV-2 nucleocapsid dimer
6991
In SARS-CoV-2, the virus that causes COVID-19, nucleocapsid is a complex molecule with many functional parts. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Repairing DNA
3493
Like a watch wrapped around a wrist, a special enzyme encircles the double helix to repair a broken strand of DNA. Tom Ellenberger, Washington University School of Medicine View Media
Chemokine CXCR4 receptor
3365
The receptor is shown bound to a small molecule peptide called CVX15. Raymond Stevens, The Scripps Research Institute View Media
VDAC-1 (3)
2494
The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View Media
Protein kinases as cancer chemotherapy targets
7004
Protein kinases—enzymes that add phosphate groups to molecules—are cancer chemotherapy targets because they play significant roles in almost all aspects of cell function, are tightly regulated, and co Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Human endoplasmic reticulum membrane protein complex
6777
A 3D model of the human endoplasmic reticulum membrane protein complex (EMC) that identifies its nine essential subunits. Rebecca Voorhees, California Institute of Technology. View Media
Pig alpha amylase
2412
Crystals of porcine alpha amylase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Beta-galactosidase montage showing cryo-EM improvement--transparent background
5882
Composite image of beta-galactosidase showing how cryo-EM’s resolution has improved dramatically in recent years. Older images to the left, more recent to the right. Veronica Falconieri, Sriram Subramaniam Lab, National Cancer Institute View Media
Dengue virus membrane protein structure
3758
Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclosed by a protective membrane. Hong Zhou, UCLA View Media
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 3
3415
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media
RNA Polymerase II
2484
NIGMS-funded researchers led by Roger Kornberg solved the structure of RNA polymerase II. David Bushnell, Ken Westover and Roger Kornberg, Stanford University View Media
Bacterial glucose isomerase
2409
A crystal of bacterial glucose isomerase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Bacterial nanowire model
6580
A model of a Geobacter sulfurreducens nanowire created from cryo-electron microscopy images. Edward Egelman, University of Virginia. View Media
H1N1 Influenza Virus
6356
Related to image 6355. Dr. Rommie Amaro, University of California, San Diego View Media
Dopamine D3 receptor
3363
The receptor is shown bound to an antagonist, eticlopride Raymond Stevens, The Scripps Research Institute View Media
Rotavirus structure
3584
This image shows a computer-generated, three-dimensional map of the rotavirus structure. This virus infects humans and other animals and causes severe diarrhea in infants and young children. Bridget Carragher, The Scripps Research Institute, La Jolla, CA View Media
Protein crystals
1060
Structural biologists create crystals of proteins, shown here, as a first step in a process called X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Map of protein structures 01
2365
A global "map of the protein structure universe." The Berkeley Structural Genomics Center has developed a method to visualize the vast universe of protein structures in which proteins of similar struc Berkeley Structural Genomics Center, PSI View Media
Aldolase
6350
2.5Å resolution reconstruction of rabbit muscle aldolase collected on a FEI/Thermo Fisher Titan Krios with energy filter and image corrector. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media
Calcium uptake during ATP production in mitochondria
3449
Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (blue) are stained with DAPI. Lili Guo, Perelman School of Medicine, University of Pennsylvania View Media
Dynamic cryo-EM model of the human transcription preinitiation complex
5730
Gene transcription is a process by which information encoded in DNA is transcribed into RNA. Eva Nogales, Berkeley Lab View Media
Atomic Structure of Poppy Enzyme
3422
The atomic structure of the morphine biosynthetic enzyme salutaridine reductase bound to the cofactor NADPH. The substrate salutaridine is shown entering the active site. Judy Coyle, Donald Danforth Plant Science Center View Media
Protein rv2844 from M. tuberculosis
2343
This crystal structure shows a conserved hypothetical protein from Mycobacterium tuberculosis. Only 12 other proteins share its sequence homology, and none has a known function. Integrated Center for Structure and Function Innovation View Media
VDAC-1 (1)
2488
The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View Media
Hsp33 figure 2
3355
Featured in the March 15, 2012 issue of Biomedical Beat. Related to Hsp33 Figure 1, image 3354. Ursula Jakob and Dana Reichmann, University of Michigan View Media
Microscopy image of bird-and-flower DNA origami
3690
An atomic force microscopy image shows DNA folded into an intricate, computer-designed structure. Hao Yan, Arizona State University View Media
Antitoxin GhoS (Illustration 2)
3428
Structure of the bacterial antitoxin protein GhoS. GhoS inhibits the production of a bacterial toxin, GhoT, which can contribute to antibiotic resistance. Rebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State University View Media
Enzyme transition states
3429
The molecule on the left is an electrostatic potential map of the van der Waals surface of the transition state for human purine nucleoside phosphorylase. Vern Schramm, Albert Einstein College of Medicine of Yeshiva University View Media
Kinesin moves cellular cargo
3491
A protein called kinesin (blue) is in charge of moving cargo around inside cells and helping them divide. Charles Sindelar, Yale University View Media
Protein folding video
3391
Proteins are long chains of amino acids. Each protein has a unique amino acid sequence. It is still a mystery how a protein folds into the proper shape based on its sequence. Theoretical and Computational Biophysics Group View Media
Fly by night
2417
This fruit fly expresses green fluorescent protein (GFP) in the same pattern as the period gene, a gene that regulates circadian rhythm and is expressed in all sensory neurons on the surface of the fl Jay Hirsh, University of Virginia View Media
Structure of Glutamate Dehydrogenase
3421
Some children are born with a mutation in a regulatory site on this enzyme that causes them to over-secrete insulin when they consume protein. Judy Coyle, Donald Danforth Plant Science Center View Media
Cysteine dioxygenase from mouse
2347
Model of the mammalian iron enzyme cysteine dioxygenase from a mouse. Center for Eukaryotic Structural Genomics, PSI View Media
RNA folding in action
6625
An RNA molecule dynamically refolds itself as it is being synthesized. When the RNA is short, it ties itself into a “knot” (dark purple). Julius Lucks, Northwestern University View Media
