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This is a searchable collection of scientific photos, illustrations, and videos. The images and videos in this gallery are licensed under Creative Commons Attribution Non-Commercial ShareAlike 3.0. This license lets you remix, tweak, and build upon this work non-commercially, as long as you credit and license your new creations under identical terms.

Heat shock protein complex from Methanococcus jannaschii

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Model based on X-ray crystallography of the structure of a small heat shock protein complex from the bacteria, Methanococcus jannaschii. Berkeley Structural Genomics Center, PSI-1 View Media

G switch (with labels and stages)

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The G switch allows our bodies to respond rapidly to hormones. G proteins act like relay batons to pass messages from circulating hormones into cells. Crabtree + Company View Media

Closeup of fluorescent C. elegans showing muscle and ribosomal protein

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Closeup of C. elegans, tiny roundworms, with a ribosomal protein glowing red and muscle fibers glowing green. Researchers used these worms to study a molecular pathway that affects aging. Jarod Rollins, Mount Desert Island Biological Laboratory. View Media

Dynamin Fission

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Time lapse series shows short dynamin assemblies (not visible) constricting a lipid tube to make a "beads on a string" appearance, then cutting off one of the beads i.e., catalyzing membrane fission). Ramachandran, Pucadyil et al. , The Scripps Research Institute View Media

Coronavirus spike protein structure

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Coronaviruses are enveloped viruses responsible for 30 percent of mild respiratory infections and atypical deadly pneumonia in humans worldwide. Melody Campbell, UCSF View Media

Serum albumin structure 1

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Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versatile protein. Wladek Minor, University of Virginia View Media

Dimeric ferredoxin-like protein from an unidentified marine microbe

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This is the first structure of a protein derived from the metagenomic sequences collected during the Sorcerer II Global Ocean Sampling project. Joint Center for Structural Genomics View Media

Arachnoidiscus diatom

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An Arachnoidiscus diatom with a diameter of 190µm. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media

Pig trypsin (3)

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Crystals of porcine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

Snowflake DNA origami

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An atomic force microscopy image shows DNA folded into an intricate, computer-designed structure. The image is featured on Biomedical Beat blog post Cool Images: A Holiday-Themed Collection. Hao Yan, Arizona State University View Media

Bacteriophage P22 capsid

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Cryo-electron microscopy (cryo-EM) has the power to capture details of proteins and other small biological structures at the molecular level.  This image shows proteins in the capsid, or outer co Dr. Wah Chiu, Baylor College of Medicine View Media

Worm sperm

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To develop a system for studying cell motility in unnatrual conditions -- a microscope slide instead of the body -- Tom Roberts and Katsuya Shimabukuro at Florida State University disassembled and rec Tom Roberts, Florida State University View Media

Dengue virus membrane protein structure

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Dengue virus is a mosquito-borne illness that infects millions of people in the tropics and subtropics each year. Like many viruses, dengue is enclosed by a protective membrane. Hong Zhou, UCLA View Media

Atomic-level structure of the HIV capsid

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This animation shows atoms of the HIV capsid, the shell that encloses the virus's genetic material. Juan R. Perilla and the Theoretical and Computational Biophysics Group, University of Illinois at Urbana-Champaign View Media

Cysteine dioxygenase from mouse

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Model of the mammalian iron enzyme cysteine dioxygenase from a mouse. Center for Eukaryotic Structural Genomics, PSI View Media

Cas4 nuclease protein structure

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This wreath represents the molecular structure of a protein, Cas4, which is part of a system, known as CRISPR, that bacteria use to protect themselves against viral invaders. Fred Dyda, NIDDK View Media

Cells keep their shape with actin filaments and microtubules

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This image shows a normal fibroblast, a type of cell that is common in connective tissue and frequently studied in research labs. James J. Faust and David G. Capco, Arizona State University View Media

Jack bean concanavalin A

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Crystals of jack bean concanavalin A protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

3-D Architecture of a Synapse

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This image shows the structure of a synapse, or junction between two nerve cells in three dimensions. From the brain of a mouse. Anton Maximov, The Scripps Research Institute, La Jolla, CA View Media

Catalase diversity

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Catalases are some of the most efficient enzymes found in cells. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media

X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 3

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media

VDAC-1 (2)

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The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View Media

Structure of amyloid-forming prion protein

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This structure from an amyloid-forming prion protein shows one way beta sheets can stack. Douglas Fowler, University of Washington View Media

Rotavirus structure

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This image shows a computer-generated, three-dimensional map of the rotavirus structure. This virus infects humans and other animals and causes severe diarrhea in infants and young children. Bridget Carragher, The Scripps Research Institute, La Jolla, CA View Media

Shiga toxin

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E. coli bacteria normally live harmlessly in our intestines, but some cause disease by making toxins. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media

Brains of sleep-deprived and well-rested fruit flies

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On top, the brain of a sleep-deprived fly glows orange because of Bruchpilot, a communication protein between brain cells. These bright orange brain areas are associated with learning. Chiara Cirelli, University of Wisconsin-Madison View Media

Sphingolipid S1P1 receptor

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The receptor is shown bound to an antagonist, ML056. Raymond Stevens, The Scripps Research Institute View Media

A2A adenosine receptor

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The receptor is shown bound to an inverse agonist, ZM241385. Raymond Stevens, The Scripps Research Institute View Media

Structure of Glutamate Dehydrogenase

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Some children are born with a mutation in a regulatory site on this enzyme that causes them to over-secrete insulin when they consume protein. Judy Coyle, Donald Danforth Plant Science Center View Media

TFIID complex binds DNA to start gene transcription

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Gene transcription is a process by which the genetic information encoded in DNA is transcribed into RNA. Eva Nogales, Berkeley Lab View Media

Dynamic cryo-EM model of the human transcription preinitiation complex

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Gene transcription is a process by which information encoded in DNA is transcribed into RNA. Eva Nogales, Berkeley Lab View Media

Z rings in bacterial division

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Lab-made liposomes contract where Z rings have gathered together and the constriction forces are greatest (arrows). Masaki Osawa, Duke University View Media

Artificial cilia exhibit spontaneous beating

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Researchers have created artificial cilia that wave like the real thing. Zvonimir Dogic View Media

Protein crystals

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Structural biologists create crystals of proteins, shown here, as a first step in a process called X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

Kappa opioid receptor

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The receptor is shown bound to an antagonist, JDTic. Raymond Stevens, The Scripps Research Institute View Media

Calcium uptake during ATP production in mitochondria

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Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (blue) are stained with DAPI. Lili Guo, Perelman School of Medicine, University of Pennsylvania View Media

Epithelial cell migration

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High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media

Protein map

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Network diagram showing a map of protein-protein interactions in a yeast (Saccharomyces cerevisiae) cell. This cluster includes 78 percent of the proteins in the yeast proteome. Hawoong Jeong, KAIST, Korea View Media

Enzyme transition states

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The molecule on the left is an electrostatic potential map of the van der Waals surface of the transition state for human purine nucleoside phosphorylase. Vern Schramm, Albert Einstein College of Medicine of Yeshiva University View Media

Structure of heme, side view

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Molecular model of the struture of heme. Heme is a small, flat molecule with an iron ion (dark red) at its center. Rachel Kramer Green, RCSB Protein Data Bank View Media

Early life of a protein

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This illustration represents the early life of a protein—specifically, apomyoglobin—as it is synthesized by a ribosome and emerges from the ribosomal tunnel, which contains the newly formed protein's Silvia Cavagnero, University of Wisconsin, Madison View Media

Aldolase

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2.5Å resolution reconstruction of rabbit muscle aldolase collected on a FEI/Thermo Fisher Titan Krios with energy filter and image corrector. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media

Assembly of the HIV capsid

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The HIV capsid is a pear-shaped structure that is made of proteins the virus needs to mature and become infective. John Grime and Gregory Voth, The University of Chicago View Media

Molecular interactions

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This network map shows molecular interactions (yellow) associated with a congenital condition that causes heart arrhythmias and the targets for drugs that alter these interactions (red and blue). Ravi Iyengar, Mount Sinai School of Medicine View Media

PSI: from genes to structures

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The goal of the Protein Structure Initiative (PSI) is to determine the three-dimensional shapes of a wide range of proteins by solving the structures of representative members of each protein family f National Institute of General Medical Sciences View Media

Sleep and the fly brain

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In the top snapshots, the brain of a sleep-deprived fruit fly glows orange, marking high concentrations of a synaptic protein called Bruchpilot (BRP) involved in communication between neurons. Chiara Cirelli, University of Wisconsin-Madison View Media

Nuclear Lamina

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The 3D single-molecule super-resolution reconstruction of the entire nuclear lamina in a HeLa cell was acquired using the TILT3D platform. Anna-Karin Gustavsson, Ph.D. View Media

Kinases

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Kinases are enzymes that add phosphate groups (red-yellow structures) to proteins (green), assigning the proteins a code. Crabtree + Company View Media

Cell curvature

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Rendering of the surface of an endothelial cell; membrane curvature is color coded. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View Media

Protein involved in cell division from Mycoplasma pneumoniae

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Model of a protein involved in cell division from Mycoplasma pneumoniae. This model, based on X-ray crystallography, revealed a structural domain not seen before. Berkeley Structural Genomics Center, PSI View Media