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This is a searchable collection of scientific photos, illustrations, and videos. The images and videos in this gallery are licensed under Creative Commons Attribution Non-Commercial ShareAlike 3.0. This license lets you remix, tweak, and build upon this work non-commercially, as long as you credit and license your new creations under identical terms.

Dynamic cryo-EM model of the human transcription preinitiation complex

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Gene transcription is a process by which information encoded in DNA is transcribed into RNA. Eva Nogales, Berkeley Lab View Media

Hsp33 figure 2

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Featured in the March 15, 2012 issue of Biomedical Beat. Related to Hsp33 Figure 1, image 3354. Ursula Jakob and Dana Reichmann, University of Michigan View Media

Seeing signaling protein activation in cells 03

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Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. Klaus Hahn, University of North Carolina, Chapel Hill Medical School View Media

Serum albumin structure 3

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Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versatile protein. Wladek Minor, University of Virginia View Media

Protein crystals

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Structural biologists create crystals of proteins, shown here, as a first step in a process called X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

Nociceptin/orphanin FQ peptide opioid receptor

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The receptor is shown bound to an antagonist, compound-24 Raymond Stevens, The Scripps Research Institute View Media

Structure of heme, side view

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Molecular model of the struture of heme. Heme is a small, flat molecule with an iron ion (dark red) at its center. Rachel Kramer Green, RCSB Protein Data Bank View Media

Sphingolipid S1P1 receptor

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The receptor is shown bound to an antagonist, ML056. Raymond Stevens, The Scripps Research Institute View Media

Dense tubular matrices in the peripheral endoplasmic reticulum (ER) 2

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Three-dimensional reconstruction of a tubular matrix in a thin section of the peripheral endoplasmic reticulum between the plasma membranes of the cell. Jennifer Lippincott-Schwartz, Howard Hughes Medical Institute Janelia Research Campus, Virginia View Media

Full-length serotonin receptor (ion channel)

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A 3D reconstruction, created using cryo-electron microscopy, of an ion channel known as the full-length serotonin receptor in complex with the antinausea drug granisetron (orange). Sudha Chakrapani, Case Western Reserve University School of Medicine. View Media

Map of protein structures 02

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A global "map of the protein structure universe" indicating the positions of specific proteins. Berkeley Structural Genomics Center, PSI View Media

Closeup of fluorescent C. elegans showing muscle and ribosomal protein

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Closeup of C. elegans, tiny roundworms, with a ribosomal protein glowing red and muscle fibers glowing green. Researchers used these worms to study a molecular pathway that affects aging. Jarod Rollins, Mount Desert Island Biological Laboratory. View Media

X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 4

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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media

Secreted protein from Mycobacteria

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Model of a major secreted protein of unknown function, which is only found in mycobacteria, the class of bacteria that causes tuberculosis. Mycobacterium Tuberculosis Center, PSI View Media

Protein folding video

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Proteins are long chains of amino acids. Each protein has a unique amino acid sequence. It is still a mystery how a protein folds into the proper shape based on its sequence. Theoretical and Computational Biophysics Group View Media

Structure of Glutamate Dehydrogenase

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Some children are born with a mutation in a regulatory site on this enzyme that causes them to over-secrete insulin when they consume protein. Judy Coyle, Donald Danforth Plant Science Center View Media

Tiny strands of tubulin, a protein in a cell's skeleton

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Just as our bodies rely on bones for structural support, our cells rely on a cellular skeleton. Pakorn Kanchanawong, National University of Singapore and National Heart, Lung, and Blood Institute, National Institutes of Health; and Clare Waterman, National Heart, Lung, and Blood Institute, National Institutes of Health View Media

Bovine milk alpha-lactalbumin (2)

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Crystals of bovine milk alpha-lactalbumin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

Cas4 nuclease protein structure

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This wreath represents the molecular structure of a protein, Cas4, which is part of a system, known as CRISPR, that bacteria use to protect themselves against viral invaders. Fred Dyda, NIDDK View Media

DNA replication origin recognition complex (ORC)

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A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recogni Huilin Li, Brookhaven National Laboratory View Media

Structure of amyloid-forming prion protein

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This structure from an amyloid-forming prion protein shows one way beta sheets can stack. Douglas Fowler, University of Washington View Media

Dimeric ferredoxin-like protein from an unidentified marine microbe

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This is the first structure of a protein derived from the metagenomic sequences collected during the Sorcerer II Global Ocean Sampling project. Joint Center for Structural Genomics View Media

Cytochrome structure with anticancer drug

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This image shows the structure of the CYP17A1 enzyme (ribbons colored from blue N-terminus to red C-terminus), with the associated heme colored black. Emily Scott, University of Kansas View Media

Pig trypsin (1)

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A crystal of porcine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

Plant resistosome

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The research organism Arabidopsis thaliana forms a large molecular machine called a resistosome to fight off infections. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media

Nicotinic acid phosphoribosyltransferase

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Model of the enzyme nicotinic acid phosphoribosyltransferase. Berkeley Structural Genomics Center, PSI View Media

Cell curvature

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Rendering of the surface of an endothelial cell; membrane curvature is color coded. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View Media

PanB from M. tuberculosis (2)

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Model of an enzyme, PanB, from Mycobacterium tuberculosis, the bacterium that causes most cases of tuberculosis. This enzyme is an attractive drug target. Mycobacterium Tuberculosis Center, PSI-1 View Media

Wreath-shaped protein from X. campestris

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Crystal structure of a protein with unknown function from Xanthomonas campestris, a plant pathogen. Eight copies of the protein crystallized to form a ring. Ken Schwinn and Sonia Espejon-Reynes, New York SGX Research Center for Structural Genomics View Media

Atomic Structure of Poppy Enzyme

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The atomic structure of the morphine biosynthetic enzyme salutaridine reductase bound to the cofactor NADPH. The substrate salutaridine is shown entering the active site. Judy Coyle, Donald Danforth Plant Science Center View Media

Bovine trypsin

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A crystal of bovine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

Molecules blocking Huntington's protein production

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The molecules that glow blue in these cultured cells prevent the expression of the mutant proteins that cause Huntington's disease. Jiaxin Hu, David W. Dodd and Robert H. E. Hudson, UT Southwestern Medical Center View Media

Human endoplasmic reticulum membrane protein complex

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A 3D model of the human endoplasmic reticulum membrane protein complex (EMC) that identifies its nine essential subunits. Rebecca Voorhees, California Institute of Technology. View Media

Relapsing fever bacterium (gray) and red blood cells

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Relapsing fever is caused by a bacterium and transmitted by certain soft-bodied ticks or body lice. The disease is seldom fatal in humans, but it can be very serious and prolonged. NIAID View Media

Bacterial glucose isomerase

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A crystal of bacterial glucose isomerase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media

Oligoendopeptidase F from B. stearothermophilus

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Crystal structure of oligoendopeptidase F, a protein slicing enzyme from Bacillus stearothermophilus, a bacterium that can cause food products to spoil. Accelerated Technologies Center for Gene to 3D Structure/Midwest Center for Structural Genomics View Media

Fluorescent C. elegans showing muscle and ribosomal protein

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C. elegans, a tiny roundworm, with a ribosomal protein glowing red and muscle fibers glowing green. Researchers used these worms to study a molecular pathway that affects aging. Jarod Rollins, Mount Desert Island Biological Laboratory. View Media

Katanin protein regulates anaphase

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The microtubule severing protein, katanin, localizes to chromosomes and regulates anaphase A in mitosis. David Sharp, Albert Einstein College of Medicine View Media

Trp_RS - tryptophanyl tRNA-synthetase family of enzymes

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This image represents the structure of TrpRS, a novel member of the tryptophanyl tRNA-synthetase family of enzymes. View Media

Measles virus proteins

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A cross section of the measles virus in which six proteins (enlarged on the outside of the virus) work together to infect cells. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media

TFIID complex binds DNA to start gene transcription

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Gene transcription is a process by which the genetic information encoded in DNA is transcribed into RNA. Eva Nogales, Berkeley Lab View Media

Protein formation

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Proteins are 3D structures made up of smaller units. DNA is transcribed to RNA, which in turn is translated into amino acids. NIGMS, with the folded protein illustration adapted from Jane Richardson, Duke University Medical Center View Media

The 26S proteasome engages with a protein substrate

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The proteasome is a critical multiprotein complex in the cell that breaks down and recycles proteins that have become damaged or are no longer needed. Andreas Martin, HHMI View Media

CRISPR

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RNA incorporated into the CRISPR surveillance complex is positioned to scan across foreign DNA. Cryo-EM density from a 3Å reconstruction is shown as a yellow mesh. NRAMM National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media

Early ribbon drawing of a protein

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This ribbon drawing of a protein hand drawn and colored by researcher Jane Richardson in 1981 helped originate the ribbon representation of proteins that is now ubiquitous in molecular graphics. Jane Richardson, Duke University Medical Center View Media

Cytonemes in developing fruit fly cells

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Scientists have long known that multicellular organisms use biological molecules produced by one cell and sensed by another to transmit messages that, for instance, guide proper development of organs Sougata Roy, University of California, San Francisco View Media

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