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Shiga toxin being sorted inside a cell
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Shiga toxin (green) is sorted from the endosome into membrane tubules (red), which then pinch off and move to the Golgi apparatus. Somshuvra Mukhopadhyay, The University of Texas at Austin, and Adam D. Linstedt, Carnegie Mellon University View MediaA Growing Bacterial Biofilm
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A growing Vibrio cholerae (cholera) biofilm. Cholera bacteria form colonies called biofilms that enable them to resist antibiotic therapy within the body and other challenges to their growth. Jing Yan, Ph.D., and Bonnie Bassler, Ph.D., Department of Molecular Biology, Princeton University, Princeton, NJ. View MediaHistone deacetylases
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The human genome contains much of the information needed for every cell in the body to function. However, different types of cells often need different types of information. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View MediaHsp33 Heat Shock Protein Inactive to Active
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When the heat shock protein hsp33 is folded, it is inactive and contains a zinc ion, stabilizing the redox sensitive domain (orange). Dana Reichmann, University of Michigan View MediaIon channel
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A special "messy" region of a potassium ion channel is important in its function. Yu Zhoi, Christopher Lingle Laboratory, Washington University School of Medicine in St. Louis View MediaChang Shan
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For thousands of years, Chinese herbalists have treated malaria using Chang Shan, a root extract from a type of hydrangea that grows in Tibet and Nepal. Paul Schimmel Lab, Scripps Research Institute View MediaKinesin moves cellular cargo
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A protein called kinesin (blue) is in charge of moving cargo around inside cells and helping them divide. Charles Sindelar, Yale University View Media3-D Architecture of a Synapse
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This image shows the structure of a synapse, or junction between two nerve cells in three dimensions. From the brain of a mouse. Anton Maximov, The Scripps Research Institute, La Jolla, CA View MediaEpithelial cell migration
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High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. Michael Shribak, Marine Biological Laboratory/University of Chicago. View MediaDopamine D3 receptor
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The receptor is shown bound to an antagonist, eticlopride Raymond Stevens, The Scripps Research Institute View MediaCytonemes in developing fruit fly cells
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Scientists have long known that multicellular organisms use biological molecules produced by one cell and sensed by another to transmit messages that, for instance, guide proper development of organs Sougata Roy, University of California, San Francisco View MediaDisease-susceptible Arabidopsis leaf
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This is a magnified view of an Arabidopsis thaliana leaf after several days of infection with the pathogen Hyaloperonospora arabidopsidis. Jeff Dangl, University of North Carolina, Chapel Hill View MediaAbnormal, spiky fibroblast
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This is a fibroblast, a connective tissue cell that plays an important role in wound healing. Normal fibroblasts have smooth edges. Praveen Suraneni, Stowers Institute for Medical Research, Kansas City, Mo. View MediaHIV enzyme
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These images model the molecular structures of three enzymes with critical roles in the life cycle of the human immunodeficiency virus (HIV). Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View MediaHen egg lysozyme (1)
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Crystals of hen egg lysozyme protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View MediaRhodopsin bound to visual arrestin
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Rhodopsin is a pigment in the rod cells of the retina (back of the eye). It is extremely light-sensitive, supporting vision in low-light conditions. Protein Data Bank. View MediaAldolase
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2.5Å resolution reconstruction of rabbit muscle aldolase collected on a FEI/Thermo Fisher Titan Krios with energy filter and image corrector. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View MediaA2A adenosine receptor
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The receptor is shown bound to an inverse agonist, ZM241385. Raymond Stevens, The Scripps Research Institute View Media