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Fruit fly ovarioles
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Three fruit fly (Drosophila melanogaster) ovarioles (yellow, blue, and magenta) with egg cells visible inside them. Ovarioles are tubes in the reproductive systems of female insects. Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View Media
Human blood cells with Borrelia hermsii, a bacterium that causes relapsing fever
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Relapsing fever is caused by a bacterium and transmitted by certain soft-bodied ticks or body lice. The disease is seldom fatal in humans, but it can be very serious and prolonged. NIAID View Media
A molecular switch strips transcription factor from DNA
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In this video, Rice University scientists used molecular modeling with a mathematical algorithm called AWSEM (for associative memory, water-mediated, structure and energy model) and structural data to Davit Potoyan and Peter Wolynes View Media
Cryo-ET cross-section of the Golgi apparatus
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On the left, a cross-section slice of a rat pancreas cell captured using cryo-electron tomography (cryo-ET). On the right, a 3D, color-coded version of the image highlighting cell structures. Xianjun Zhang, University of Southern California. View Media
Cell-like compartments from frog eggs
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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View Media
Antibiotic-surviving bacteria
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Colonies of bacteria growing despite high concentrations of antibiotics. These colonies are visible both by eye, as seen on the left, and by bioluminescence imaging, as seen on the right. Paul Stoodley, The Ohio State University. View Media
CRISPR Illustration Frame 2
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This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. National Institute of General Medical Sciences. View Media
Statistical cartography
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Like a world of its own, this sphere represents all the known chemical reactions in the E. coli bacterium. Luis A. Nunes Amaral, Northwestern University View Media
Bacterial alpha amylase
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A crystal of bacterial alpha amylase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Mapping metabolic activity
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Like a map showing heavily traveled roads, this mathematical model of metabolic activity inside an E. coli cell shows the busiest pathway in white. Albert-László Barabási, University of Notre Dame View Media
Jack bean concanavalin A
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Crystals of jack bean concanavalin A protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Glow-in-the-dark salamanders
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These six-month-old axolotls, a kind of salamander, glow green and blue under ultraviolet light. That's because they were genetically modified to make harmless green fluorescent protein, or GFP. View Media
Mitochondria and endoplasmic reticulum
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A computer model shows how the endoplasmic reticulum is close to and almost wraps around mitochondria in the cell. The endoplasmic reticulum is lime green and the mitochondria are yellow. Bridget Wilson, University of New Mexico View Media
Yeast cells entering mitosis
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Yeast cells entering mitosis, also known as cell division. The green and magenta dots are two proteins that play important roles in mitosis. They show where the cells will split. Alaina Willet, Kathy Gould’s lab, Vanderbilt University. View Media
Molecular model of freshly made Rous sarcoma virus (RSV)
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Viruses have been the foes of animals and other organisms for time immemorial. Boon Chong Goh, University of Illinois at Urbana-Champaign View Media
Cell-like compartments from frog eggs 3
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Cell-like compartments that spontaneously emerged from scrambled frog eggs. Endoplasmic reticulum (red) and microtubules (green) are visible. Image created using epifluorescence microscopy. Xianrui Cheng, Stanford University School of Medicine. View Media
X-ray diffraction pattern from a crystallized cefotaxime-CCD-1 complex
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CCD-1 is an enzyme produced by the bacterium Clostridioides difficile that helps it resist antibiotics. Keith Hodgson, Stanford University. View Media
Young squids
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Real-time movie of young squids. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media
Small blood vessels in a mouse retina
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Blood vessels at the back of the eye (retina) are used to diagnose glaucoma and diabetic eye disease. They also display characteristic changes in people with high blood pressure. National Center for Microscopy and Imaging Research View Media
Cone snail shell
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A shell from the venomous cone snail Conus omaria, which lives in the Pacific and Indian oceans and eats other snails. Kerry Matz, University of Utah View Media
Axolotls showing nervous system components
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Axolotls—a type of salamander—that have been genetically modified so that various parts of their nervous systems glow purple and green. Prayag Murawala, MDI Biological Laboratory and Hannover Medical School. View Media
Human Adenovirus
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The cryo-EM structure of human adenovirus D26 (HAdV-D26) at near atomic resolution (3.7 Å), determined in collaboration with the NRAMM facility*. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media
Cytoscape network diagram 1
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Molecular biologists are increasingly relying on bioinformatics software to visualize molecular interaction networks and to integrate these networks with data such as gene expression profiles. Keiichiro Ono, Trey Ideker lab, University of California, San Diego View Media
3D image of actin in a cell
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Actin is an essential protein in a cell's skeleton (cytoskeleton). It forms a dense network of thin filaments in the cell. Xiaowei Zhuang, Howard Hughes Medical Institute, Harvard University View Media
Network diagram of genes, cellular components and processes (labeled)
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This image shows the hierarchical ontology of genes, cellular components and processes derived from large genomic datasets. From Dutkowski et al. Janusz Dutkowski and Trey Ideker, University of California, San Diego View Media
Centromeres on human chromosomes
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Human metaphase chromosomes are visible with fluorescence in vitro hybridization (FISH). Centromeric alpha satellite DNA (green) are found in the heterochromatin at each centromere. Peter Warburton, Mount Sinai School of Medicine View Media
Cell-like compartments emerging from scrambled frog eggs 3
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Cell-like compartments spontaneously emerge from scrambled frog eggs. Endoplasmic reticulum (red) and microtubules (green) are visible. Video created using epifluorescence microscopy. Xianrui Cheng, Stanford University School of Medicine. View Media
Automated crystal screening system
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Automated crystal screening systems such as the one shown here are becoming a common feature at synchrotron and other facilities where high-throughput crystal structure determination is being carried Southeast Collaboratory for Structural Genomics View Media
Tracking embryonic zebrafish cells
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To better understand cell movements in developing embryos, researchers isolated cells from early zebrafish embryos and grew them as clusters. Liliana Solnica-Krezel, Washington University School of Medicine in St. Louis. View Media
Cryo-ET cell cross-section visualizing insulin vesicles
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On the left, a cross-section slice of a rat pancreas cell captured using cryo-electron tomography (cryo-ET). On the right, a color-coded, 3D version of the image highlighting cell structures. Xianjun Zhang, University of Southern California. View Media
Mounting of protein crystals
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Automated methods using micromachined silicon are used at the Northeast Collaboratory for Structural Genomics to mount protein crystals for X-ray crystallography. The Northeast Collaboratory for Structural Genomics View Media
Trigonium diatom
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A Trigonium diatom imaged by a quantitative orientation-independent differential interference contrast (OI-DIC) microscope. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media
Nano-rainbow
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These vials may look like they're filled with colored water, but they really contain nanocrystals reflecting different colors under ultraviolet light. Shuming Nie, Emory University View Media
Fungal lipase (2)
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Crystals of fungal lipase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Petri dish containing C. elegans
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This Petri dish contains microscopic roundworms called Caenorhabditis elegans. Researchers used these particular worms to study how C. H. Robert Horvitz and Dipon Ghosh, Massachusetts Institute of Technology. View Media
Network diagram of genes, cellular components and processes (unlabeled)
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This image shows the hierarchical ontology of genes, cellular components and processes derived from large genomic datasets. From Dutkowski et al. Janusz Dutkowski and Trey Ideker View Media
Cell-like compartments from frog eggs 6
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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View Media
Fruit fly larvae brains showing tubulin
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Two fruit fly (Drosophila melanogaster) larvae brains with neurons expressing fluorescently tagged tubulin protein. Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View Media
Adult Hawaiian bobtail squid burying in the sand
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Each morning, the nocturnal Hawaiian bobtail squid, Euprymna scolopes, hides from predators by digging into the sand. At dusk, it leaves the sand again to hunt. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Mouse brain 3
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Various views of a mouse brain that was genetically modified so that subpopulations of its neurons glow. Prayag Murawala, MDI Biological Laboratory and Hannover Medical School. View Media
Cell-like compartments emerging from scrambled frog eggs 4
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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View Media
Pig trypsin crystal
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A crystal of pig trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
CRISPR illustration
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This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. National Institute of General Medical Sciences. View Media
Staphylococcus aureus in the porous coating of a femoral hip stem
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Staphylococcus aureus bacteria (blue) on the porous coating of a femoral hip stem used in hip replacement surgery. Paul Stoodley, The Ohio State University. View Media
ATP Synthase
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Atomic model of the membrane region of the mitochondrial ATP synthase built into a cryo-EM map at 3.6 Å resolution. ATP synthase is the primary producer of ATP in aerobic cells. Bridget Carragher, <a href="http://nramm.nysbc.org/">NRAMM National Resource for Automated Molecular Microscopy</a> View Media
“Two-faced” Janus particle activating a macrophage
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A macrophage—a type of immune cell that engulfs invaders—“eats” and is activated by a “two-faced” Janus particle. Yan Yu, Indiana University, Bloomington. View Media
Honeybees marked with paint
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Researchers doing behavioral experiments with honeybees sometimes use paint or enamel to give individual bees distinguishing marks. Gene Robinson, University of Illinois at Urbana-Champaign. View Media
Cell-free protein synthesizers
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Both instruments shown were developed by CellFree Sciences of Yokohama, Japan. Center for Eukaryotic Structural Genomics View Media
Developing zebrafish fin
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Originally from the waters of India, Nepal, and neighboring countries, zebrafish can now be found swimming in science labs (and home aquariums) throughout the world. Jessica Plavicki View Media
Confocal microscopy of perineuronal nets in the brain 1
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The photo shows a confocal microscopy image of perineuronal nets (PNNs), which are specialized extracellular matrix (ECM) structures in the brain. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
