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Precisely Delivering Chemical Cargo to Cells
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Moving protein or other molecules to specific cells to treat or examine them has been a major biological challenge. Nature Nanotechnology View Media3D image of actin in a cell
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Actin is an essential protein in a cell's skeleton (cytoskeleton). It forms a dense network of thin filaments in the cell. Xiaowei Zhuang, Howard Hughes Medical Institute, Harvard University View MediaCell-like compartments from frog eggs 6
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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View MediaNano-rainbow
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These vials may look like they're filled with colored water, but they really contain nanocrystals reflecting different colors under ultraviolet light. Shuming Nie, Emory University View MediaCell-like compartments from frog eggs 5
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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View MediaCas9 protein involved in the CRISPR gene-editing technology
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In the gene-editing tool CRISPR, a small strand of RNA identifies a specific chunk of DNA. Janet Iwasa View MediaCell-like compartments emerging from scrambled frog eggs 2
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Cell-like compartments spontaneously emerge from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View MediaBacterial alpha amylase
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A crystal of bacterial alpha amylase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View MediaAutomated Worm Sorter - 4
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Georgia Tech associate professor Hang Lu holds a microfluidic chip that is part of a system that uses artificial intelligence and cutting-edge image processing to automatically examine large number of Georgia Tech/Gary Meek View MediaCRISPR Illustration Frame 1
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This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. This is the first frame in a series of four. National Institute of General Medical Sciences. View MediaCulex quinquefasciatus mosquito larvae
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Mosquito larvae with genes edited by CRISPR swimming in water. Valentino Gantz, University of California, San Diego. View MediaCell-free protein synthesizers
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Both instruments shown were developed by CellFree Sciences of Yokohama, Japan. Center for Eukaryotic Structural Genomics View MediaA molecular switch strips transcription factor from DNA
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In this video, Rice University scientists used molecular modeling with a mathematical algorithm called AWSEM (for associative memory, water-mediated, structure and energy model) and structural data to Davit Potoyan and Peter Wolynes View MediaHuman embryonic stem cells on feeder cells
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This fluorescent microscope image shows human embryonic stem cells whose nuclei are stained green. Blue staining shows the surrounding supportive feeder cells. Michael Longaker lab, Stanford University School of Medicine, via CIRM View MediaPetri dish containing C. elegans
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This Petri dish contains microscopic roundworms called Caenorhabditis elegans. Researchers used these particular worms to study how C. H. Robert Horvitz and Dipon Ghosh, Massachusetts Institute of Technology. View MediaBiosensors illustration
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A rendering of an activity biosensor image overlaid with a cell-centered frame of reference used for image analysis of signal transduction. Gaudenz Danuser, Harvard Medical School View MediaGlycan arrays
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The signal is obtained by allowing proteins in human serum to interact with glycan (polysaccharide) arrays. The arrays are shown in replicate so the pattern is clear. Ola Blixt, Scripps Research Institute View MediaSpace-filling model of a cefotaxime-CCD-1 complex
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CCD-1 is an enzyme produced by the bacterium Clostridioides difficile that helps it resist antibiotics. Keith Hodgson, Stanford University. View MediaSuperconducting magnet
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Superconducting magnet for NMR research, from the February 2003 profile of Dorothee Kern in Findings. Mike Lovett View MediaMicrotubules in hippocampal neurons
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Microtubules (magenta) in neurons of the hippocampus, a part of the brain involved in learning and memory. Microtubules are strong, hollow fibers that provide structural support to cells. Melike Lakadamyali, Perelman School of Medicine at the University of Pennsylvania. View MediaCorrelative imaging by annotation with single molecules (CIASM) process
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These images illustrate a technique combining cryo-electron tomography and super-resolution fluorescence microscopy called correlative imaging by annotation with single molecules (CIASM). Peter Dahlberg, Stanford University. View Media