In addition to their systems-level studies of complex biological phenomena, the NIGMS-supported National Centers for Systems Biology engage in a variety of training and outreach activities. One recent example is a curriculum for first-year graduate students created by the New York Center for Systems Biology. This material introduces computational principles and approaches that are becoming increasingly important across the biomedical sciences. If you would like to know more about this course and/or download materials such as lecture slides or problem sets, please see the Teaching Resources section (no longer available) of the September 13, 20 and 27 issues of Science Signaling. To learn more about the systems biology centers and their offerings, visit the systems biology portal (no longer available).