UPDATE: The response deadline has been extended to November 13.

On July 29, 2015, the White House issued an Executive Order establishing the National Strategic Computing Initiative as a government-wide effort to create a coordinated, cohesive, multi-agency strategy to maximize the benefits of High Performance Computing (HPC) for the United States. In support of this initiative, the Department of Energy, National Science Foundation and National Institutes of Health are seeking your input to identify scientific research that would benefit from a greatly enhanced new generation of HPC computing technologies and architectures. The request for information (RFI) asks for responses in scientific domains including the biomedical and physical sciences, mathematics, geosciences, energy sciences and engineering research.

We hope to hear from our research communities on topics that include:

• Research challenges that would need the projected 100-fold increase in application performance.
• Specific barriers in current HPC systems that limit scientific research.
• Capabilities needed for the data-intensive sciences.
• Additional barriers in such areas as training, workforce development or collaborative environments.

While this RFI invites comments on several specific topics, we would also welcome any comments that you feel are relevant to this initiative.

To respond to this RFI, send an email to NIGMS_exascale@nigms.nih.gov by October 16.

If you have any specific questions about the RFI, please let me know.