Under Jeremy Berg’s leadership, NIGMS has thrived and continued to support outstanding, cutting-edge research. I hope to maintain this momentum while serving as acting NIGMS director. Many of you know me from the Division of Genetics and Developmental Biology, the part of NIGMS I’ve directed since 1988. Others know me from the NIH Director’s Pioneer and New Innovator Award programs, which I’ve led for a number of years, or from my role in chairing NIGMS’ strategic planning processes. Some may even recall when I previously served as acting NIGMS director (from May 2002, when Marvin Cassman left, to November 2003, when Jeremy arrived). In this time of transition, we are managing a challenging budget situation and also pursuing several major activities. One is implementing action items from the training strategic plan. I am excited to see this effort come to fruition, as it will have a significant impact on both students in our training programs and those supported by regular research grants. In addition, we are looking forward to marking the Institute’s 50th anniversary in 2012. Planning is already under way for activities at scientific meetings and on the NIH campus. We will post more details here in the coming months. And of course we eagerly anticipate the selection of a new NIGMS director. The search committee is a terrific group of people who know the Institute well. I have a lot of confidence that they will find us a director who will continue NIGMS’ strong tradition of excellent leadership. Part of Jeremy’s legacy at NIGMS is the Feedback Loop. Keeping open lines of communication has always been really important to us, and I welcome your input at any time.

Today is my last day as Director of NIGMS. It is hard to believe that almost 8 years have passed since I was first offered this tremendous opportunity to serve the scientific community. It has been a privilege to work with the outstanding staff members at NIGMS and NIH, as well as with so many of you across the country. As I write my final post, I find myself recalling a statement I heard from then-NIH Director Elias Zerhouni during my first few years here: It is very difficult to translate that which you do not understand. He made this comment in the context of discussions about the balance between basic and applied research, which certainly has applicability in this setting and is relevant in a broader context as well. In some ways, it has also been my mantra for the NIGMS Feedback Loop. Early in my time at NIH, I was struck by how often even relatively well-informed members of the scientific community did not understand the underlying bases for NIH policies and trends. Information voids were often filled with rumors that were sometimes very far removed from reality. The desire to provide useful information to the scientific community motivated me and others at NIGMS to start the Feedback Loop, first as an electronic newsletter and, for the past 2 years, as a blog. Our goal was--and is--to provide information and data that members of the scientific community can use to take maximal advantage of the opportunities provided across NIH and to understand the rationales behind long-standing and more recent NIH policies and initiatives. I chose the name Feedback Loop with the hope that this venue would provide more than just a vehicle for pushing out information. I wanted it to promote two-way communication, with members of the scientific community feeling comfortable sharing their thoughts about the material presented or about other issues of interest to them. In biology, feedback loops serve as important regulatory mechanisms that allow systems to adjust to changes in their environments. I hoped that NIGMS' "feedback loop" would serve a similar role. I am pleased with our progress toward this goal, but there is considerable room for further evolution. The emergence and success of similar blogs such as Rock Talk are encouraging signs. I know that NIGMS Acting Director Judith Greenberg shares my enthusiasm for communication with the community, and I hope that the new NIGMS Director will too. I encourage you to continue to play your part, participate in the discussions and engage in the sort of dialogue that will best serve the scientific community. I plan to continue communicating with many of you in my new position as a member of the extramural scientific community. For the time being, you can reach me at jeremybergtemp@gmail.com.

As I enter my final few weeks at NIGMS, I’m engaged in a lot of transition planning. One major aspect is the designation of an acting director, and I’m happy to tell you that Judith Greenberg has agreed to serve in this capacity after my departure early next month. She was acting director in 2002 and 2003, after Marvin Cassman left and before I arrived, and I know that she will once again do a fantastic job. For more about Judith, see the news release we just issued.

Last November, I announced that NIGMS was conducting an assessment of its Large-Scale Collaborative Project Awards (glue grant) program and solicited your input. We have now posted the report of this assessment, which is based on an analysis of input from six different sources, including comments we received from the scientific community. The assessment’s conclusion is that the glue grant program has had mixed results. All of the projects accomplished some of their goals, and some of the projects had a substantial impact in their fields. However, the assessment also found that the program as a whole had not achieved outcomes commensurate with the scope of the awards and the overall investment in them. The panel members felt that “the successes and challenges of the Glue Grant Awards Program provide a useful guide for the development of future programs.” While they recommended discontinuing the program as it currently exists, they did not recommend abandoning all support for collaborative research, even in the face of tighter budgets. Rather, they suggested a number of ways to improve support for larger-scale projects and indicated that these projects cannot be accomplished with R01 grant support alone. Last week, I presented the outcomes of the assessment to our Advisory Council, which embraced the recommendations of the assessment panel and encouraged NIGMS to develop alternative mechanisms to support the varied accomplishments that were supported through the glue grant program. We will take the report and Council’s advice into consideration as we develop future plans for funding collaborative research.

The Feedback Loop blog, with its 165 posts and 418 comments, has become an important tool for communicating with you. As the blog enters its third year, we will continue to use it to share news of NIGMS funding opportunities, meetings and activities, job openings and grant-related changes. But, as with any blog, we really want to generate posts that spark an open dialogue. Tell us what posts you want to read by e-mailing me, adding a comment here or using the “Suggest a Post” option near the top of the site. Is there a policy or process we can demystify, a trend we can explain or an area of funding we should highlight? You can propose any topic that might interest our broader NIGMS grantee and applicant audience. While you’re at it, you can also tell us what you don’t want to read about!

At today's National Advisory General Medical Sciences Council meeting, member Howard Garrison offered the following statement to Jeremy Berg on behalf of the entire Council: “In appreciation of your 7 years of leadership at NIGMS, the members of the Council express their profound gratitude to you for your distinguished service to science and the nation. We recognize your outstanding work in the pursuit of excellence in research and education, mentoring and advocacy for basic research. Your willingness to deal directly with challenging issues has earned you our respect and admiration. It has been a pleasure and an honor to work with you, and we will miss you. We wish you continued success in your new endeavors.”

NIH is seeking broad input from the scientific community on challenges and opportunities in single-cell analysis, a topic of great interest and relevance to many NIGMS grantees and applicants. Please help NIH shape its future programs in this emerging research area by sending in your opinions. The request for information (RFI) asks for responses on topics including:

• Current conceptual, technical and/or methodological challenges in the field;
• Major biomedical research questions that can be addressed by single-cell analysis; and
• The highest priority tools and resources needed to move forward.

We hope you'll take the time to weigh in with your opinions and specific examples between now and the March 18 response deadline. Let me know if you would like to learn more about trans-NIH activities in this area, as I'm a member of the group that issued this RFI—the Single Cell Analysis Working Group of the NIH Common Fund (formerly known as the NIH Roadmap), which provides strategic planning, coordination and support for programs that cut across NIH institutes and centers.

I have previously noted that NIH has proposed creating a new entity, the National Center for Advancing Translational Sciences (NCATS), to house a number of existing programs relating to the discipline of translational science and the development of novel therapeutics. Plans for NCATS have been coupled to a proposal to dismantle the National Center for Research Resources (NCRR), in part because the largest program within NCRR, the Clinical and Translational Science Awards, would be transferred to NCATS and in part because of a statutory limitation on the number of institutes and centers at NIH. NIH leadership established a task force to determine the placement of NCRR programs within NIH. This group initially developed a “straw model” for discussion and more recently submitted its recommendations to the NIH Director. The recommendations include transferring the Institutional Development Award (IDeA) program and some Biomedical Technology Research Centers and other technology research and development grants to NIGMS at the beginning of Fiscal Year 2012. As you may be aware, I have expressed concerns about the processes associated with the proposal to abolish NCRR. I hope it is clear that my concerns relate to the processes and not to the NCRR programs, which I hold in very high regard. This opinion is also clearly shared by many others in the scientific community, based on comments on the Feedback NIH site and in other venues. While there are several additional steps that would need to occur before organizational changes could take place, we at NIGMS are already deepening our understanding of the NCRR programs through meetings with NCRR staff and others directly familiar with the programs. We welcome your input, as well, particularly if you have experience with these NCRR programs. Please comment here or contact me directly.

The NIH Scientific Management Review Board will hold a teleconference on Wednesday, February 23, from 11:30 a.m. to 1:30 p.m. Eastern time. The discussion will focus on the NIH proposal to create a new National Center for Advancing Translational Sciences (NCATS) and its impact on other programs at NIH, including the National Center for Research Resources.

The teleconference is open to the public and time will be available for public comment, but those wishing to make comments need to sign up in advance. Details are in a Federal Register notice.

The toll-free number to participate in the teleconference is 1-800-779-1545. The participant passcode to give the meeting operator is "NIH."

The launch of the International Year of Chemistry 2011 is a good opportunity to reflect on the NIGMS role in supporting research in this central field of science. NIGMS is the leading institute at NIH in funding chemical research, supporting a range of studies focusing on such areas as the development of synthetic methodologies for new drug discovery and synthesis; the role of metals in biological systems; and the discovery of new analytical techniques for the detection, identification and quantification of human metabolites. In fact, just about every branch of chemistry has a connection to the study of human health. We’re proud that our support has led to many breakthroughs and significant honors, including 36 Nobel Prizes in chemistry. We also play a major role in training in chemistry through both research grant support and training awards. In 1992, we initiated the Chemistry-Biology Interface institutional predoctoral training grant program, which today supports chemistry students who wish to be cross-trained in biology and biologists who wish to be cross-trained in chemistry in 23 institutions across the country. And you can frequently find NIGMS-supported postdocs in the labs of leading chemists. We foster effective mentoring in chemistry in a variety of ways. One example is the mentoring workshops we’ve sponsored since 2005 for new faculty in organic and bio-organic chemistry, who meet once or twice each year. Representatives from the federal agencies that support chemical research, including NIH, the National Science Foundation (NSF), the Department of Energy (DOE), the Army Research Office, the Air Force Office of Scientific Research, the Office of Naval Research, the Environmental Protection Agency, the Department of Agriculture and the National Institute of Standards and Technology, meet annually to compare notes on our different programs and discuss cross-cutting issues. These exchanges can lead to collaborations, such as the workshops for chemistry department chairs that NIGMS, DOE and NSF have co-sponsored for several years now to help increase diversity in the ranks of chemistry faculty. You can read reports at http://chemchairs.uoregon.edu/display/GenderEquity.pdf and http://chemchairs.uoregon.edu/urm/images/urmreport.pdf (Links no longer available). And we will participate with NSF and DOE in a “FedFunders Town Hall Meeting” at the American Chemical Society (ACS) national meeting in Anaheim on Monday, March 28, from 4:30 to 6:30 p.m. This event is a good forum for meeting and talking with staff from the three agencies. The staff at NIGMS who handle chemistry research portfolios are always ready to talk with grantees, applicants and potential applicants about chemistry and support for chemistry projects, and we can frequently be spotted at chemistry-related scientific meetings. Miles Fabian and I will be at the Anaheim ACS meeting and John Schwab plans to attend the ACS fall meeting in Denver. We hope to see some of you there.