2024 Stetten Lecture

Molecular Mechanisms Underlying Glycinergic Neurotransmission​​

Sudha Chakrapani, Ph.D.

John H. Hord Professor and Chair, Department of Pharmacology
Director, Cleveland Center for Membrane and Structural Biology
Case Western Reserve University

NIH Building 10, Lipsett Amphitheater and NIH Videocast
National Institutes of Health
Bethesda, Maryland
Start Date:
11/20/2024 Time: 2:00 PM ET
End Date:
11/20/2024 Time: 3:00 PM ET
A headshot of Sudha Chakrapani
Credit: Courtesy of Dr. Sudha Chakrapani.

​Biographical Sketch

Born and raised in India, Dr. Sudha Chakrapani came to the United States after completing her master’s degree in biomedical engineering. She received her Ph.D. in physiology and biophysics from the University at Buffalo and went on to complete postdoctoral positions at the University of Virginia and the University of Chicago. In 2010, she joined the faculty at Case Western Reserve University in Cleveland, Ohio, in the department of physiology and biophysics. She is now a professor and chair of the department of pharmacology and serves as the director of the Cleveland Center for Membrane and Structural Biology.

Over the last 25 years, Dr. Chakrapani’s research has focused ​on ionchannels that mediate fast synaptic transmission at the neuronal and neuromuscular junction. She is especially interested in understanding the critical interaction between ion channels and bioactive lipids, including how this interaction is altered in the presence of different molecules like neurosteroids, alcohols, and anesthetics. Her lab’s scientific approach combines cutting-edge multidisciplinary tools that include cryo-electron microscopy (Cryo-EM) and X-ray crystallography for high-resolution structure determination, electron paramagnetic resonance (EPR) spectroscopy for protein dynamic measurements, and electrophysiology for functional characterization of ion channels. These techniques complement each other and provide an atomic description of how structure and dynamics govern protein functioning.

Dr. Chakrapani is supported by the NIGMS Maximizing Investigators’ Research Award program through grant R35GM134896.