NIGMS Programs in Specific Scientific Areas

NIGMS supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention. Most applications to NIGMS are not in response to a specific solicitation, but the Institute does fund research in several special areas, a selection of which appear below. For more information, see the complete list of all NIGMS research funding opportunities, programs and grant mechanisms.

Active Programs

Cellular Imaging
Research that applies and develops imaging technologies to understand the underlying biology and dynamic processes of living cells.

Clinical Research Areas
Clinical research within the mission of the PPBC Division​ at ​NIGMS.

Mathematical Biology
An interagency program designed to bring mathematics into the core of biological research and to broaden the use of innovative mathematics in understanding life processes.

Models of Infectious Disease Agent Study (MIDAS) Link to external website
A collaboration of scientists who conduct research on computational modeling to improve the detection, control, and prevention of emerging infectious diseases. ​The MIDAS Coordination Center Link to external website plays a key role in organizing and facilitating infectious disease modeling research. The Center provides data services to the network, including metadata design and creation, data standardization, and a data discovery and access portal. It also coordinates communication between researchers, students, and public health practitioners.​

Science of Science Policy Approach to Analyzing and Innovating the Biomedical Research Enterprise (SCISIPBIO)
An interagency program to advance the scientific basis of science and innovation policy, with a focus on the biomedical sciences.

Stem Cell Initiatives
Initiatives to encourage and facilitate basic research on pluripotent stem cells, such as human embryonic stem cells and induced pluripotent stem cells, including their use as model systems.

Systems Biology
Centers focused on systems-level studies of biomedical phenomena.

Past Programs

AIDS-Related Structural Biology Program
Research focused on the basic structural, biophysical and cell biological investigation of HIV and its interaction with the host cell. The program was transferred from NIGMS to the National Institute for Allergies and Infectious Diseases (NIAID) in 2019. More information can be found on NIAID's Centers for HIV Structural Biology page.

Large-Scale Collaborative Project Awards (Glue Grant) Program
Consortia that brought together large, interdisciplinary teams of researchers to solve complex problems in biomedical science.

Protein Structure Initiative
An effort to apply high-throughput structure determination methods to study a broad range of important biological and biomedical problems.

Supplements for Collaborative Science
Administrative supplements that enabled NIGMS grantees to form new collaborations to support the goals of funded grants.