National Institute of
General Medical Sciences

NIGMS supports investigator-initiated clinical research. Focus areas include (with links to Staff Contacts):

Anesthesiology - Research related to anesthesiology and peri-operative pain

Contact Zuzana Justinova

Clinical Pharmacology - Research related to drug delivery, biotransformation and disposition, pharmacokinetics, and modeling (however, studies aimed at specific diseases should be discussed with the institutes focused on those missions)

Contact Sailaja Koduri

Sepsis - Research related to the etiology of sepsis and septic shock, with emphasis on the host response

Contact Xiaoli Zhao

• Report of the NAGMSC Working Group on Sepsis [PDF, 2.64MB]
• NOT-GM-19-054, Notice of Information: NIGMS Priorities for Sepsis Research
• NOT-GM-19-057, Request for Information (RFI): Strategies to Support Acquisition and Use of Biospecimens for Research on Sepsis in Humans
• NOT-GM-20-028, Notice of Special Interest: NIGMS Priorities for Small Business Development of Sepsis Diagnostics and Therapeutics
• NOT-NS-20-005, Research in the Emergency Care Setting
• PAR-21-077, Exploring the Scientific Value of Existing or New Sepsis Human Biospecimen Collections

Injury and Critical Illness - Research related to injury including whole body biochemical, cellular, and patho​physiological changes induced by trauma

Contact Chris Chao

• NOT-NS-20-005, Research in the Emergency Care Setting

Multi-organ and Systemic Responses - Research related to cellular and molecular mediators of inflammation and innate immunity underlying complex pathophysiological responses​

Contact Xiaoli Zhao

• NOT-ES-20-018, Promoting Fundamental and Applied Research in Inflammation Resolution

Wound Healing - Research related to mechanisms of post-injury healing and tissue repair

Contact Chris Chao

• NOT-NS-20-005, Research in the Emergency Care Setting

Clinical Resources for Investigators Applying to NIGMS

Investigators are strongly encouraged to consult with NIGMS staff at the earliest stages to plan research grant applications that might involve Clinical Studies and Trials.

Clinical Training, Career Development, and Fellowship Awards

NIGMS supports clinical research training for institutions and individuals. Programs include:

• Institutional Postdoctoral Training Grants (T32)
• Mentored Career Development Awards (K08, K23)
• Individual Postdoctoral National Research Service Awards (F32)

Small Business Awards Offered in Clinical Areas

NIGMS supports research and development conducted by U.S. small businesses for activities that have strong potential for commercialization. Programs include:

• Small Business Innovation Research (SBIR, R43/R44)
• Small Business Technology Transfer (STTR, R41/R42)

NIGMS also participates in the Commercialization Readiness Pilot (CRP) program designed to facilitate the transition of previously funded SBIR and STTR Phase 2 and Phase 2B projects to the commercialization stage by providing additional support for technical assistance.

Note a particular interest described in NOT-GM-20-028, Notice of Special Interest: NIGMS Priorities for Small Business Development of Sepsis Diagnostics and Therapeutics

Multidisciplinary Teams/Collaborative Research Awards Offered in Clinical Areas

The NIGMS Collaborative Program Grant for Multidisciplinary Teams (RM1) can support an application from a highly integrated team of investigators addressing a single-focus, ambitious, and challenging project that cannot be achieved with individual research grant awards.

• Collaborative Program Grant for Multidisciplinary Teams (RM1)