National Institute of
Clinical Research Areas Supported by Pharmacology, Physiology, and Biological Chemistry
NIGMS supports investigator-initiated clinical research. Focus areas include (with links to Staff Contacts):
Anesthesiology - Research related to anesthesiology and peri-operative pain
Contact: Zuzana Justinova
Clinical Pharmacology - Research related to drug delivery, biotransformation and disposition, pharmacokinetics, and modeling (however, studies aimed at specific diseases should be discussed with the institutes focused on those missions)
Contact: Sailaja Koduri
Sepsis - Research related to the etiology of sepsis and septic shock, with emphasis on the host response
Contact: Xiaoli Zhao
- Report of the NAGMSC Working Group on Sepsis [PDF]
- NOT-GM-19-054, Notice of Information: NIGMS Priorities for Sepsis Research
- PAR-21-077, Exploring the Scientific Value of Existing or New Sepsis Human Biospecimen Collections (expired, but awards can be viewed here)
- Investigators’ Meeting, held Sept. 20-21, 2023
- NOT-GM-24-018, NIGMS Support to Utilize Data and Biospecimens Generated by the ARDS, Pneumonia, and Sepsis Phenotyping (APS) Consortium
Injury and Critical Illness - Research related to injury including whole body biochemical, cellular, and pathophysiological changes induced by trauma
Contact: Chris Chao
Systemic Immune/Inflammatory Responses - Research related to cellular and molecular mediators of inflammation and innate immunity underlying complex pathophysiological responses
Contact: Xiaoli Zhao
- NOT-ES-20-018, Promoting Fundamental and Applied Research in Inflammation Resolution
Wound Healing - Research related to mechanisms of post-injury healing and tissue repair
Contact: Chris Chao
Clinical Resources for Investigators Applying to NIGMS
Investigators are strongly encouraged to consult with NIGMS staff at the earliest stages to plan research grant applications that might involve Clinical Studies and Trials.
Clinical Training, Career Development, and Fellowship Awards
NIGMS supports clinical research training for institutions and individuals. Programs include:
- Institutional Postdoctoral Training Grants (T32)
- Mentored Career Development Awards (K08, K23)
- Individual Postdoctoral National Research Service Awards (F32)
Small Business Awards Offered in Clinical Areas
NIGMS supports research and development conducted by U.S. small businesses for activities that have strong potential for commercialization. Programs include:
- Small Business Innovation Research (SBIR, R43/R44)
- Small Business Technology Transfer (STTR, R41/R42)
NIGMS also participates in the Commercialization Readiness Pilot (CRP) program designed to facilitate the transition of previously funded SBIR and STTR Phase 2 and Phase 2B projects to the commercialization stage by providing additional support for technical assistance.
Multidisciplinary Teams/Collaborative Research Awards Offered in Clinical Areas
The NIGMS Collaborative Program Grant for Multidisciplinary Teams (RM1) can support an application from a highly integrated team of investigators addressing a single-focus, ambitious, and challenging project that cannot be achieved with individual research grant awards.
A clinical research topic must be central to the NIGMS mission and based in the institute's clinical areas of interest. Advance consultation with staff is highly recommended.