Clinical Research Areas Supported by Pharmacology, Physiology, and Biological Chemistry

NIGMS supports investigator-initiated clinical research. Focus areas include (with links to Staff Contacts):

Anesthesiology - Research related to anesthesiology and peri-operative pain

Clinical Pharmacology - Research related to drug delivery, biotransformation and disposition, pharmacokinetics, and modeling

Sepsis - Research related to the etiology of sepsis and septic shock, with emphasis on the host response

Innate Immunity and Inflammation - Research related to cellular and molecular mediators of inflammatory disorders

  • NOT-ES-20-018, Promoting Fundamental and Applied Research in Inflammation Resolution

Injury and Critical Illness - Research related to injury, including biochemical and physiological changes induced by trauma

Wound Healing - Research related to post-injury healing and tissue repair

Clinical Resources for Investigators Applying to NIGMS

Investigators are strongly encouraged to consult with NIGMS staff at the earliest stages to plan research grant applications that might involve Clinical Studies and Trials.

Clinical Training, Career Development, and Fellowship Awards

NIGMS supports clinical research training for institutions and individuals. Programs include:

Small Business Awards Offered in Clinical Areas

NIGMS supports research and development conducted by U.S. small businesses for activities that have strong potential for commercialization. Programs include:

NIGMS also participates in the Commercialization Readiness Pilot (CRP) program designed to facilitate the transition of previously funded SBIR and STTR Phase 2 and Phase 2B projects to the commercialization stage by providing additional support for technical assistance.

Note a particular interest described in NOT-GM-20-028, Notice of Special Interest: NIGMS Priorities for Small Business Development of Sepsis Diagnostics and Therapeutics

Multidisciplinary Teams/Collaborative Research Awards Offered in Clinical Areas

The NIGMS Collaborative Program Grant for Multidisciplinary Teams (RM1) can support an application from a highly integrated team of investigators addressing a single-focus, ambitious, and challenging project that cannot be achieved with individual research grant awards. 

A clinical research topic must be central to the NIGMS mission and based in the institute's clinical areas of interest. Advance consultation with staff​ is highly recommended.