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Nuclear Lamina
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The 3D single-molecule super-resolution reconstruction of the entire nuclear lamina in a HeLa cell was acquired using the TILT3D platform. Anna-Karin Gustavsson, Ph.D. View Media
Transmission electron microscopy showing cross-section of the node of Ranvier
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Nodes of Ranvier are short gaps in the myelin sheath surrounding myelinated nerve cells (axons). Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Scientists display X-ray diffraction pattern obtained with split X-ray beamline
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Scientists from Argonne National Laboratory's Advanced Photon Source (APS) display the first X-ray diffraction pattern obtained from a protein crystal using a split X-ray beam, the first of its kind a GM/CA Collaborative Access Team View Media
Podocytes from a chronically diseased kidney
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This scanning electron microscope (SEM) image shows podocytes--cells in the kidney that play a vital role in filtering waste from the bloodstream--from a patient with chronic kidney disease. Olga Troyanskaya, Princeton University and Matthias Kretzler, University of Michigan View Media
Self-organizing proteins
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Under the microscope, an E. coli cell lights up like a fireball. Each bright dot marks a surface protein that tells the bacteria to move toward or away from nearby food and toxins. View Media
Chromatin in human fibroblast
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The nucleus of a human fibroblast cell with chromatin—a substance made up of DNA and proteins—shown in various colors. Melike Lakadamyali, Perelman School of Medicine at the University of Pennsylvania. View Media
“Two-faced” Janus particle activating a macrophage
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A macrophage—a type of immune cell that engulfs invaders—“eats” and is activated by a “two-faced” Janus particle. Yan Yu, Indiana University, Bloomington. View Media
High-throughput protein structure determination pipeline
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This slide shows the technologies that the Joint Center for Structural Genomics developed for going from gene to structure and how the technologies have been integrated into a high-throughput pipeline Joint Center for Structural Genomics View Media
Mouse retina
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What looks like the gossamer wings of a butterfly is actually the retina of a mouse, delicately snipped to lay flat and sparkling with fluorescent molecules. Tom Deerinck and Keunyoung (“Christine”) Kim, NCMIR View Media
NMR spectrometer
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This photo shows a Varian Unity Inova 900 MHz, 21.1 T standard bore magnet Nuclear Magnetic Resonnance (NMR) spectrometer. Center for Eukaryotic Structural Genomics View Media
Modeling disease spread
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What looks like a Native American dream catcher is really a network of social interactions within a community. Stephen Eubank, University of Virginia Biocomplexity Institute (formerly Virginia Bioinformatics Institute) View Media
Bacterial alpha amylase
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A crystal of bacterial alpha amylase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Fly cells
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If a picture is worth a thousand words, what's a movie worth? Denise Montell, Johns Hopkins University School of Medicine View Media
Cell division and cell death
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Two cells over a 2-hour period. The one on the bottom left goes through programmed cell death, also known as apoptosis. The one on the top right goes through cell division, also called mitosis. Dylan T. Burnette, Vanderbilt University School of Medicine. View Media
Scanning electron microscopy of the ECM on the surface of a calf muscle
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This image shows the extracellular matrix (ECM) on the surface of a soleus (lower calf) muscle in light brown and blood vessels in pink. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Crawling cell
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A crawling cell with DNA shown in blue and actin filaments, which are a major component of the cytoskeleton, visible in pink. Actin filaments help enable cells to crawl. Dylan T. Burnette, Vanderbilt University School of Medicine. View Media
Electrostatic map of the adeno-associated virus
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The new highly efficient parallelized DelPhi software was used to calculate the potential map distribution of an entire virus, the adeno-associated virus, which is made up of more than 484,000 atoms. Emil Alexov, Clemson University View Media
Protein purification robot
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Irina Dementieva, a biochemist, and Youngchang Kim, a biophysicist and crystallographer, work with the first robot of its type in the U.S. to automate protein purification. Midwest Center for Structural Genomics View Media
Tracking embryonic zebrafish cells
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To better understand cell movements in developing embryos, researchers isolated cells from early zebrafish embryos and grew them as clusters. Liliana Solnica-Krezel, Washington University School of Medicine in St. Louis. View Media
Bioluminescent imaging in adult zebrafish 04
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Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. View Media
Human endoplasmic reticulum membrane protein complex
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A 3D model of the human endoplasmic reticulum membrane protein complex (EMC) that identifies its nine essential subunits. Rebecca Voorhees, California Institute of Technology. View Media
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 7
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media
Human retinal organoid
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A replica of a human retina grown from stem cells. Kevin Eliceiri, University of Wisconsin-Madison. View Media
Human embryonic stem cells on feeder cells
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This fluorescent microscope image shows human embryonic stem cells whose nuclei are stained green. Blue staining shows the surrounding supportive feeder cells. Michael Longaker lab, Stanford University School of Medicine, via CIRM View Media
CCP enzyme
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The enzyme CCP is found in the mitochondria of baker’s yeast. Scientists study the chemical reactions that CCP triggers, which involve a water molecule, iron, and oxygen. Protein Data Bank. View Media
Axolotl showing nervous system
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The head of an axolotl—a type of salamander—that has been genetically modified so that its developing nervous system glows purple and its Schwann cell nuclei appear light blue. Prayag Murawala, MDI Biological Laboratory and Hannover Medical School. View Media
Cytochrome structure with anticancer drug
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This image shows the structure of the CYP17A1 enzyme (ribbons colored from blue N-terminus to red C-terminus), with the associated heme colored black. Emily Scott, University of Kansas View Media
Crab larva eye
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Colorized scanning electron micrographs progressively zoom in on the eye of a crab larva. In the higher-resolution frames, bacteria are visible on the eye. Tina Weatherby Carvalho, University of Hawaii at Manoa View Media
Staphylococcus aureus aggregates on microstructured titanium surface
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Groups of Staphylococcus aureus bacteria (blue) attached to a microstructured titanium surface (green) that mimics an orthopedic implant used in joint replacement. Paul Stoodley, The Ohio State University. View Media
C. elegans with blue and yellow lights in the background
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These microscopic roundworms, called Caenorhabditis elegans, lack eyes and the opsin proteins used by visual systems to detect colors. H. Robert Horvitz and Dipon Ghosh, Massachusetts Institute of Technology. View Media
Video of Calling Cards in a mouse brain
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The green spots in this mouse brain are cells labeled with Calling Cards, a technology that records molecular events in brain cells as they mature. <em>NIH Director’s Blog</em>. View Media
Microarray 01
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Microarrays, also called gene chips, are tools that let scientists track the activity of hundreds or thousands of genes simultaneously. Maggie Werner-Washburne, University of New Mexico, Albuquerque View Media
Cryo-ET cell cross-section visualizing insulin vesicles
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On the left, a cross-section slice of a rat pancreas cell captured using cryo-electron tomography (cryo-ET). On the right, a color-coded, 3D version of the image highlighting cell structures. Xianjun Zhang, University of Southern California. View Media
Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 1
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Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. Matthew West and Greg Odorizzi, University of Colorado View Media
Cryo-ET cross-section of a rat pancreas cell
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On the left, a cross-section slice of a rat pancreas cell captured using cryo-electron tomography (cryo-ET). On the right, a 3D, color-coded version of the image highlighting cell structures. Xianjun Zhang, University of Southern California. View Media
Hawaiian bobtail squid
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An adult Hawaiian bobtail squid, Euprymna scolopes, swimming next to a submerged hand. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Cell-like compartments from frog eggs 5
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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View Media
A molecular interaction network in yeast 1
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The image visualizes a part of the yeast molecular interaction network. Keiichiro Ono, UCSD View Media
CRISPR Illustration Frame 3
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This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. National Institute of General Medical Sciences. View Media
Human blood cells with Borrelia hermsii, a bacterium that causes relapsing fever
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Relapsing fever is caused by a bacterium and transmitted by certain soft-bodied ticks or body lice. The disease is seldom fatal in humans, but it can be very serious and prolonged. NIAID View Media
Calling Cards in a mouse brain
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The green spots in this mouse brain are cells labeled with Calling Cards, a technology that records molecular events in brain cells as they mature. Allen Yen, Lab of Joseph Dougherty, Washington University School of Medicine in St. Louis. View Media
Zebrafish head vasculature
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A zebrafish head with blood vessels shown in purple. Prayag Murawala, MDI Biological Laboratory and Hannover Medical School. View Media
Precisely Delivering Chemical Cargo to Cells
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Moving protein or other molecules to specific cells to treat or examine them has been a major biological challenge. Nature Nanotechnology View Media
Genetic mosaicism in fruit flies
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Fat tissue from the abdomen of a genetically mosaic adult fruit fly. Genetic mosaicism means that the fly has cells with different genotypes even though it formed from a single zygote. Akhila Rajan, Fred Hutchinson Cancer Center View Media
Yeast cells with nuclei and contractile rings
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Yeast cells with nuclei shown in green and contractile rings shown in magenta. Nuclei store DNA, and contractile rings help cells divide. Alaina Willet, Kathy Gould’s lab, Vanderbilt University. View Media
RNase A (1)
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A crystal of RNase A protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
CRISPR Illustration Frame 4
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This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. National Institute of General Medical Sciences. View Media
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 4
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media
A dynamic model of the DNA helicase protein complex
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This short video shows a model of the DNA helicase in yeast. This DNA helicase has 11 proteins that work together to unwind DNA during the process of copying it, called DNA replication. Huilin Li, Stony Brook University View Media
Scanning electron microscopy of collagen fibers
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This image shows collagen, a fibrous protein that's the main component of the extracellular matrix (ECM). Collagen is a strong, ropelike molecule that forms stretch-resistant fibers. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
