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Confocal microscopy image of two Drosophila ovarioles
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Ovarioles in female insects are tubes in which egg cells (called oocytes) form at one end and complete their development as they reach the other end of the tube. 2004 Olympus BioScapes Competition View MediaFat cells (red) and blood vessels (green)
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A mouse's fat cells (red) are shown surrounded by a network of blood vessels (green). Daniela Malide, National Heart, Lung, and Blood Institute, National Institutes of Health View MediaApoptosis reversed
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Two healthy cells (bottom, left) enter into apoptosis (bottom, center) but spring back to life after a fatal toxin is removed (bottom, right; top). Hogan Tang of the Denise Montell Lab, Johns Hopkins University School of Medicine View MediaRAC1 activation in motile fibroblast
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Novel biosensor system maps the timing and location of Rac protein activation in a living mouse embryo fibroblast. Klaus Hahn, University of North Carolina, Chapel Hill Medical School View MediaMultivesicular bodies containing intralumenal vesicles assemble at the vacuole 2
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Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. Matthew West and Greg Odorizzi, University of Colorado View MediaFruit fly embryo
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Cells in an early-stage fruit fly embryo, showing the DIAP1 protein (pink), an inhibitor of apoptosis. Hermann Steller, Rockefeller University View MediaV. Cholerae Biofilm
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Industrious V. cholerae bacteria (yellow) tend to thrive in denser biofilms (left) while moochers (red) thrive in weaker biofilms (right). View MediaDopaminergic neurons from ES cells
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Human embryonic stem cells differentiated into dopaminergic neurons, the type that degenerate in Parkinson's disease. Image courtesy of the California Institute for Regenerative Medicine. Jeannie Liu, Lab of Jan Nolta, University of California, Davis, via CIRM View MediaBacteriophage P22 capsid
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Cryo-electron microscopy (cryo-EM) has the power to capture details of proteins and other small biological structures at the molecular level. This image shows proteins in the capsid, or outer co Dr. Wah Chiu, Baylor College of Medicine View MediaSkin cancer cells (squamous cell carcinoma)
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This image shows the uncontrolled growth of cells in squamous cell carcinoma, the second most common form of skin cancer. If caught early, squamous cell carcinoma is usually not life-threatening. Markus Schober and Elaine Fuchs, The Rockefeller University View MediaFocal adhesions (with labels)
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Cells walk along body surfaces via tiny "feet," called focal adhesions, that connect with the extracellular matrix. Crabtree + Company View MediaGlowing bacteria make a pretty postcard
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This tropical scene, reminiscent of a postcard from Key West, is actually a petri dish containing an artistic arrangement of genetically engineered bacteria. Nathan C. Shaner, The Scintillon Institute View MediaVimentin in a quail embryo
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Video of high-resolution confocal images depicting vimentin immunofluorescence (green) and nuclei (blue) at the edge of a quail embryo yolk. Andrés Garcia, Georgia Tech View MediaBee venom toxin destroying a cell
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This video condenses 6.5 minutes into less than a minute to show how the toxin in bee venom, called melittin, destroys an animal or bacterial cell. Huey Huang, Rice University View MediaMicrosporidia in roundworm 2
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Many disease-causing microbes manipulate their host’s metabolism and cells for their own ends. Keir Balla and Emily Troemel, University of California San Diego View MediaCell-like compartments from frog eggs 4
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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View MediaPollen grains: male germ cells in plants and a cause of seasonal allergies
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Those of us who get sneezy and itchy-eyed every spring or fall may have pollen grains, like those shown here, to blame. Edna, Gil, and Amit Cukierman, Fox Chase Cancer Center, Philadelphia, Pa. View MediaG switch (with labels and stages)
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The G switch allows our bodies to respond rapidly to hormones. G proteins act like relay batons to pass messages from circulating hormones into cells. Crabtree + Company View MediaHydra 04
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Hydra magnipapillata is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis. Hiroshi Shimizu, National Institute of Genetics in Mishima, Japan View MediaInterphase in Xenopus frog cells
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These images show frog cells in interphase. The cells are Xenopus XL177 cells, which are derived from tadpole epithelial cells. The microtubules are green and the chromosomes are blue. Claire Walczak, who took them while working as a postdoc in the laboratory of Timothy Mitchison. View MediaHeLa cells
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Scanning electron micrograph of just-divided HeLa cells. Zeiss Merlin HR-SEM. National Center for Microscopy and Imaging Research View MediaPhagosome in macrophage cell
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A sensor particle being engulfed by a macrophage—an immune cell—and encapsuled in a compartment called a phagosome. The phagosome then fuses with lysosomes—another type of compartment. Yan Yu, Indiana University, Bloomington. View MediaCancer Cells Glowing from Luciferin
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The activator cancer cell culture, right, contains a chemical that causes the cells to emit light when in the presence of immune cells. Mark Sellmyer, Stanford University School of Medicine View MediaStretch detectors
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Muscles stretch and contract when we walk, and skin splits open and knits back together when we get a paper cut. Christopher Chen, University of Pennsylvania View MediaBiofilm formed by a pathogen
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A biofilm is a highly organized community of microorganisms that develops naturally on certain surfaces. Scott Chimileski, Ph.D., and Roberto Kolter, Ph.D., Harvard Medical School. View MediaLily mitosis 05
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A light microscope image of a cell from the endosperm of an African globe lily (Scadoxus katherinae). This is one frame of a time-lapse sequence that shows cell division in action. Andrew S. Bajer, University of Oregon, Eugene View MediaEpithelial cell migration
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High-resolution time lapse of epithelial (skin) cell migration and wound healing. It shows an image taken every 13 seconds over the course of almost 14 minutes. Michael Shribak, Marine Biological Laboratory/University of Chicago. View MediaCRISPR surveillance complex
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This image shows how the CRISPR surveillance complex is disabled by two copies of anti-CRISPR protein AcrF1 (red) and one AcrF2 (light green). NRAMM National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View MediaG switch
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The G switch allows our bodies to respond rapidly to hormones. See images 2537 and 2538 for labeled versions of this image. Crabtree + Company View MediaMitotic cell awaits chromosome alignment
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During mitosis, spindle microtubules (red) attach to chromosome pairs (blue), directing them to the spindle equator. View MediaBacteriophage P22 capsid, detail
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Detail of a subunit of the capsid, or outer cover, of bacteriophage P22, a virus that infects the Salmonella bacteria. Dr. Wah Chiu, Baylor College of Medicine View MediaIon channels
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The body uses a variety of ion channels to transport small molecules across cell membranes. Judith Stoffer View MediaTracking embryonic zebrafish cells
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To better understand cell movements in developing embryos, researchers isolated cells from early zebrafish embryos and grew them as clusters. Liliana Solnica-Krezel, Washington University School of Medicine in St. Louis. View MediaPlasma membrane
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The plasma membrane is a cell's protective barrier. See image 2524 for a labeled version of this illustration. Featured in The Chemistry of Health. Crabtree + Company View MediaHuman fibroblast undergoing cell division
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During cell division, cells physically divide after separating their genetic material to create two daughter cells that are genetically identical to the parent cell. Nilay Taneja, Vanderbilt University, and Dylan T. Burnette, Ph.D., Vanderbilt University School of Medicine. View MediaLily mitosis 03
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A light microscope image of a cell from the endosperm of an African globe lily (Scadoxus katherinae). This is one frame of a time-lapse sequence that shows cell division in action. Andrew S. Bajer, University of Oregon, Eugene View MediaIndependence Day
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This graphic that resembles a firework was created from a picture of a fruit fly spermatid. Sigi Benjamin-Hong, Rockefeller University View MediaHuman ES cells turn into insulin-producing cells
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Human embryonic stem cells were differentiated into cells like those found in the pancreas (blue), which give rise to insulin-producing cells (red). Eugene Brandon, ViaCyte, via CIRM View MediaTwo mouse fibroblast cells
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Two mouse fibroblasts, one of the most common types of cells in mammalian connective tissue. They play a key role in wound healing and tissue repair. Dylan T. Burnette, Vanderbilt University School of Medicine. View MediaCell toxins
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A number of environmental factors cause DNA mutations that can lead to cancer: toxins in cigarette smoke, sunlight and other radiation, and some viruses. Judith Stoffer View MediaBacteria in the mouse colon
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Image of the colon of a mouse mono-colonized with Bacteroides fragilis (red) residing within the crypt channel. The red staining is due to an antibody to B. Sarkis K. Mazmanian, California Institute of Technology View MediaFloral pattern in a mixture of two bacterial species, Acinetobacter baylyi and Escherichia coli, grown on a semi-solid agar for 48 hours (photo 1)
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Floral pattern emerging as two bacterial species, motile Acinetobacter baylyi (red) and non-motile Escherichia coli (green), are grown together for 48 hours on 1% agar surface from a sma L. Xiong et al, eLife 2020;9: e48885 View MediaFloral pattern in a mixture of two bacterial species, Acinetobacter baylyi and Escherichia coli, grown on a semi-solid agar for 72 hour
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Floral pattern emerging as two bacterial species, motile Acinetobacter baylyi and non-motile Escherichia coli (green), are grown together for 72 hours on 0.5% agar surface from a small i L. Xiong et al, eLife 2020;9: e48885 View MediaScanning electron microscopy of the ECM on the surface of a calf muscle
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This image shows the extracellular matrix (ECM) on the surface of a soleus (lower calf) muscle in light brown and blood vessels in pink. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View MediaHighlighted cells
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The cytoskeleton (green) and DNA (purple) are highlighed in these cells by immunofluorescence. Torsten Wittmann, Scripps Research Institute View MediaInduced stem cells from adult skin 02
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These cells are induced stem cells made from human adult skin cells that were genetically reprogrammed to mimic embryonic stem cells. James Thomson, University of Wisconsin-Madison View MediaSeeing signaling protein activation in cells 01
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Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. Klaus Hahn, University of North Carolina, Chapel Hill Medical School View MediaCryo-ET cross-section of the Golgi apparatus
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On the left, a cross-section slice of a rat pancreas cell captured using cryo-electron tomography (cryo-ET). On the right, a 3D, color-coded version of the image highlighting cell structures. Xianjun Zhang, University of Southern California. View MediaFruit fly ovarioles
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Three fruit fly (Drosophila melanogaster) ovarioles (yellow, blue, and magenta) with egg cells visible inside them. Ovarioles are tubes in the reproductive systems of female insects. Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View MediaColony of human ES cells
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A colony of human embryonic stem cells (light blue) grows on fibroblasts (dark blue). California Institute for Regenerative Medicine View Media