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Cell division and cell death
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Two cells over a 2-hour period. The one on the bottom left goes through programmed cell death, also known as apoptosis. The one on the top right goes through cell division, also called mitosis. Dylan T. Burnette, Vanderbilt University School of Medicine. View Media
Heat shock protein complex from Methanococcus jannaschii
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Model based on X-ray crystallography of the structure of a small heat shock protein complex from the bacteria, Methanococcus jannaschii. Berkeley Structural Genomics Center, PSI-1 View Media
Cross section of a Drosophila melanogaster pupa lacking Draper
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In the absence of the engulfment receptor Draper, salivary gland cells (light blue) persist in the thorax of a developing Drosophila melanogaster pupa. Christina McPhee and Eric Baehrecke, University of Massachusetts Medical School View Media
Actin filaments bundled around the dynamin helical polymer
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Multiple actin filaments (magenta) are organized around a dynamin helical polymer (rainbow colored) in this model derived from cryo-electron tomography. Elizabeth Chen, University of Texas Southwestern Medical Center. View Media
Induced stem cells from adult skin 02
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These cells are induced stem cells made from human adult skin cells that were genetically reprogrammed to mimic embryonic stem cells. James Thomson, University of Wisconsin-Madison View Media
Atomic Structure of Poppy Enzyme
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The atomic structure of the morphine biosynthetic enzyme salutaridine reductase bound to the cofactor NADPH. The substrate salutaridine is shown entering the active site. Judy Coyle, Donald Danforth Plant Science Center View Media
Pathways: What's the Connection? | Different Jobs in a Science Lab
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Learn about some of the different jobs in a scientific laboratory and how researchers work as a team to make discoveries. National Institute of General Medical Sciences View Media
NCMIR Intestine-1
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The small intestine is where most of our nutrients from the food we eat are absorbed into the bloodstream. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
V. Cholerae Biofilm
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Industrious V. cholerae bacteria (yellow) tend to thrive in denser biofilms (left) while moochers (red) thrive in weaker biofilms (right). View Media
Chemokine CXCR4 receptor
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The receptor is shown bound to a small molecule peptide called CVX15. Raymond Stevens, The Scripps Research Institute View Media
Beta 2-adrenergic receptor
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The receptor is shown bound to a partial inverse agonist, carazolol. Raymond Stevens, The Scripps Research Institute View Media
PanB from M. tuberculosis (1)
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Model of an enzyme, PanB, from Mycobacterium tuberculosis, the bacterium that causes most cases of tuberculosis. This enzyme is an attractive drug target. Mycobacterium Tuberculosis Center, PSI View Media
A2A adenosine receptor
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The receptor is shown bound to an inverse agonist, ZM241385. Raymond Stevens, The Scripps Research Institute View Media
Human fibroblast undergoing cell division
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During cell division, cells physically divide after separating their genetic material to create two daughter cells that are genetically identical to the parent cell. Nilay Taneja, Vanderbilt University, and Dylan T. Burnette, Ph.D., Vanderbilt University School of Medicine. View Media
Natcher Building 04
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NIGMS staff are located in the Natcher Building on the NIH campus. Alisa Machalek, National Institute of General Medical Sciences View Media
Olfactory system
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Sensory organs have cells equipped for detecting signals from the environment, such as odors. Judith Stoffer View Media
Active site of sulfite oxidase
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Sulfite oxidase is an enzyme that is essential for normal neurological development in children. John Enemark, University of Arizona View Media
Sheep hemoglobin crystal
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A crystal of sheep hemoglobin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Cytonemes in developing fruit fly cells
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Scientists have long known that multicellular organisms use biological molecules produced by one cell and sensed by another to transmit messages that, for instance, guide proper development of organs Sougata Roy, University of California, San Francisco View Media
Dicer generates microRNAs (with labels)
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The enzyme Dicer generates microRNAs by chopping larger RNA molecules into tiny Velcro®-like pieces. MicroRNAs stick to mRNA molecules and prevent the mRNAs from being made into proteins. Crabtree + Company View Media
Fruit fly nurse cells transporting their contents during egg development
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In many animals, the egg cell develops alongside sister cells. Adam C. Martin, Massachusetts Institute of Technology. View Media
X-ray diffraction pattern from a crystallized cefotaxime-CCD-1 complex
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CCD-1 is an enzyme produced by the bacterium Clostridioides difficile that helps it resist antibiotics. Keith Hodgson, Stanford University. View Media
Crab nerve cell
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Neuron from a crab showing the cell body (bottom), axon (rope-like extension), and growth cone (top right). Tina Weatherby Carvalho, University of Hawaii at Manoa View Media
Cell cycle (with labels)
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Cells progress through a cycle that consists of phases for growth (G1, S, and G2) and division (M). Cells become quiescent when they exit this cycle (G0). Crabtree + Company View Media
The 26S proteasome engages with a protein substrate
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The proteasome is a critical multiprotein complex in the cell that breaks down and recycles proteins that have become damaged or are no longer needed. Andreas Martin, HHMI View Media
The nascent juvenile light organ of the Hawaiian bobtail squid
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A light organ (~0.5 mm across) of a Hawaiian bobtail squid, Euprymna scolopes, with different tissues are stained various colors. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Scanning electron microscopy of the ECM on the surface of a calf muscle
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This image shows the extracellular matrix (ECM) on the surface of a soleus (lower calf) muscle in light brown and blood vessels in pink. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Disease-resistant Arabidopsis leaf
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This is a magnified view of an Arabidopsis thaliana leaf a few days after being exposed to the pathogen Hyaloperonospora arabidopsidis. Jeff Dangl, University of North Carolina, Chapel Hill View Media
Morphine Structure
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The chemical structure of the morphine molecule Judy Coyle, Donald Danforth Plant Science Center View Media
Yeast cells with nuclear envelopes and tubulin
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Yeast cells with nuclear envelopes shown in magenta and tubulin shown in light blue. The nuclear envelope defines the borders of the nucleus, which houses DNA. Alaina Willet, Kathy Gould’s lab, Vanderbilt University. View Media
Nicotinic acid phosphoribosyltransferase
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Model of the enzyme nicotinic acid phosphoribosyltransferase. Berkeley Structural Genomics Center, PSI View Media
ATP synthase (with labels)
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The world's smallest motor, ATP synthase, generates energy for the cell. See image 2517 for an unlabeled version of this illustration. Crabtree + Company View Media
Fibroblasts with nuclei in blue, energy factories in green and the actin cytoskeleton in red
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The cells shown here are fibroblasts, one of the most common cells in mammalian connective tissue. These particular cells were taken from a mouse embryo. Dylan Burnette, NICHD View Media
Lysosome clusters around amyloid plaques
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It's probably most people's least favorite activity, but we still need to do it--take out our trash. Otherwise our homes will get cluttered and smelly, and eventually, we'll get sick. Swetha Gowrishankar and Shawn Ferguson, Yale School of Medicine View Media
Plasma membrane
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The plasma membrane is a cell's protective barrier. See image 2524 for a labeled version of this illustration. Featured in The Chemistry of Health. Crabtree + Company View Media
Dynamin Fission
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Time lapse series shows short dynamin assemblies (not visible) constricting a lipid tube to make a "beads on a string" appearance, then cutting off one of the beads i.e., catalyzing membrane fission). Ramachandran, Pucadyil et al. , The Scripps Research Institute View Media
SARS-CoV-2 nucleocapsid dimer
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In SARS-CoV-2, the virus that causes COVID-19, nucleocapsid is a complex molecule with many functional parts. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Telomerase illustration
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Reactivating telomerase in our cells does not appear to be a good way to extend the human lifespan. Cancer cells reactivate telomerase. Judith Stoffer View Media
Mouse cerebellum
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The cerebellum is the brain's locomotion control center. Found at the base of your brain, the cerebellum is a single layer of tissue with deep folds like an accordion. National Center for Microscopy and Imaging Research (NCMIR) View Media
Autofluorescent xanthophores in zebrafish skin
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Pigment cells are cells that give skin its color. David Parichy, University of Washington View Media
Introduction to Genome Editing Using CRISPR/Cas9
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Genome editing using CRISPR/Cas9 is a rapidly expanding field of scientific research with emerging applications in disease treatment, medical therapeutics and bioenergy, just to name a few. Janet Iwasa View Media
Atomic-level structure of the HIV capsid
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This animation shows atoms of the HIV capsid, the shell that encloses the virus's genetic material. Juan R. Perilla and the Theoretical and Computational Biophysics Group, University of Illinois at Urbana-Champaign View Media
Capillary protein crystallization robot
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This ACAPELLA robot for capillary protein crystallization grows protein crystals, freezes them, and centers them without manual intervention. Structural Genomics of Pathogenic Protozoa Consortium View Media
NCMIR human spinal nerve
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Spinal nerves are part of the peripheral nervous system. They run within the spinal column to carry nerve signals to and from all parts of the body. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Sphingolipid S1P1 receptor
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The receptor is shown bound to an antagonist, ML056. Raymond Stevens, The Scripps Research Institute View Media
Cell toxins
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A number of environmental factors cause DNA mutations that can lead to cancer: toxins in cigarette smoke, sunlight and other radiation, and some viruses. Judith Stoffer View Media
Hydra 04
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Hydra magnipapillata is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis. Hiroshi Shimizu, National Institute of Genetics in Mishima, Japan View Media
