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Bottles of warfarin
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In 2007, the FDA modified warfarin's label to indicate that genetic makeup may affect patient response to the drug. The widely used blood thinner is sold under the brand name Coumadin®. Alisa Machalek, NIGMS/NIH View Media
Protein from E. faecalis
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X-ray structure of a DNA repair enzyme superfamily representative from the human gastrointestinal bacterium Enterococcus faecalis. Midwest Center for Structural Genomics View Media
Genetic patchworks
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Each point in these colorful patchworks represents the correlation between two sleep-associated genes in fruit flies. Susan Harbison and Trudy Mackay, North Carolina State University View Media
Ear hair cells derived from embryonic stem cells
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Mouse embryonic stem cells matured into this bundle of hair cells similar to the ones that transmit sound in the ear. Stefen Heller, Stanford University, via CIRM View Media
Transient receptor potential channel TRPV5
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A 3D reconstruction of a transient receptor potential channel called TRPV5 that was created based on cryo-electron microscopy images. Vera Moiseenkova-Bell, University of Pennsylvania. View Media
Serum albumin structure 1
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Serum albumin (SA) is the most abundant protein in the blood plasma of mammals. SA has a characteristic heart-shape structure and is a highly versatile protein. Wladek Minor, University of Virginia View Media
Young squids
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Real-time movie of young squids. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media
Bacterial alpha amylase
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A crystal of bacterial alpha amylase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Measles virus
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A cross section of the measles virus in which six proteins work together to infect cells. The measles virus is extremely infectious; 9 out of 10 people exposed will contract the disease. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Protein purification facility
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The Center for Eukaryotic Structural Genomics protein purification facility is responsible for purifying all recombinant proteins produced by the center. Center for Eukaryotic Structural Genomics View Media
Lysosome clusters around amyloid plaques
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It's probably most people's least favorite activity, but we still need to do it--take out our trash. Otherwise our homes will get cluttered and smelly, and eventually, we'll get sick. Swetha Gowrishankar and Shawn Ferguson, Yale School of Medicine View Media
Wreath-shaped protein from X. campestris
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Crystal structure of a protein with unknown function from Xanthomonas campestris, a plant pathogen. Eight copies of the protein crystallized to form a ring. Ken Schwinn and Sonia Espejon-Reynes, New York SGX Research Center for Structural Genomics View Media
Chromosomes before crossing over
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Duplicated pair of chromosomes lined up and ready to cross over. Judith Stoffer View Media
Pig trypsin (3)
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Crystals of porcine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Aminopeptidase N from N. meningitidis
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Model of the enzyme aminopeptidase N from the human pathogen Neisseria meningitidis, which can cause meningitis epidemics. Midwest Center for Structural Genomics, PSI View Media
DNA replication illustration (with labels)
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During DNA replication, each strand of the original molecule acts as a template for the synthesis of a new, complementary DNA strand. Crabtree + Company View Media
Soft X-ray tomography of a pancreatic beta cell
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A color-coded, 3D model of a rat pancreatic β cell. This type of cell produces insulin, a hormone that helps regulate blood sugar. Carolyn Larabell, University of California, San Francisco. View Media
Mycobacterium tuberculosis
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Mycobacterium tuberculosis, the bacterium that causes tuberculosis, has infected one-quarter of the world's population and causes more than one million deaths each year, according to the Reuben Peters, Iowa State University View Media
Regeneration of Mouse Ears
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Normal mice, like the B6 breed pictured on the left, develop scars when their ears are pierced. Ellen Heber-Katz, The Wistar Institute View Media
VDAC-1 (3)
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The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View Media
Protein map
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Network diagram showing a map of protein-protein interactions in a yeast (Saccharomyces cerevisiae) cell. This cluster includes 78 percent of the proteins in the yeast proteome. Hawoong Jeong, KAIST, Korea View Media
Xenopus laevis egg
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Xenopus laevis, the African clawed frog, has long been used as a model organism for studying embryonic development. Michael Klymkowsky, University of Colorado, Boulder View Media
Cell-like compartments from frog eggs 3
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Cell-like compartments that spontaneously emerged from scrambled frog eggs. Endoplasmic reticulum (red) and microtubules (green) are visible. Image created using epifluorescence microscopy. Xianrui Cheng, Stanford University School of Medicine. View Media
Small blood vessels in a mouse retina
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Blood vessels at the back of the eye (retina) are used to diagnose glaucoma and diabetic eye disease. They also display characteristic changes in people with high blood pressure. National Center for Microscopy and Imaging Research View Media
Bacteria working to eat
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Gram-negative bacteria perform molecular acrobatics just to eat. Because they're encased by two membranes, they must haul nutrients across both. Emad Tajkhorshid, University of Illinois at Urbana-Champaign View Media
Pig trypsin crystal
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A crystal of pig trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Himastatin and bacteria
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A model of the molecule himastatin overlaid on an image of Bacillus subtilis bacteria. Mohammad Movassaghi, Massachusetts Institute of Technology. View Media
NCMIR mouse tail
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Stained cross section of a mouse tail. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Tracking embryonic zebrafish cells
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To better understand cell movements in developing embryos, researchers isolated cells from early zebrafish embryos and grew them as clusters. Liliana Solnica-Krezel, Washington University School of Medicine in St. Louis. View Media
Intasome
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Salk researchers captured the structure of a protein complex called an intasome (center) that lets viruses similar to HIV establish permanent infection in their hosts. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media
Anchor cell in basement membrane
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An anchor cell (red) pushes through the basement membrane (green) that surrounds it. Elliott Hagedorn, Duke University. View Media
Calling Cards in a mouse brain
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The green spots in this mouse brain are cells labeled with Calling Cards, a technology that records molecular events in brain cells as they mature. Allen Yen, Lab of Joseph Dougherty, Washington University School of Medicine in St. Louis. View Media
Kinesin moves cellular cargo
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A protein called kinesin (blue) is in charge of moving cargo around inside cells and helping them divide. Charles Sindelar, Yale University View Media
Bone cancer cell
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This image shows an osteosarcoma cell with DNA in blue, energy factories (mitochondria) in yellow, and actin filaments—part of the cellular skeleton—in purple. Dylan Burnette and Jennifer Lippincott-Schwartz, NICHD View Media
Enzyme reaction
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Enzymes speed up chemical reactions by reducing the amount of energy needed for the reactions. NIGMS View Media
Cell cycle
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Cells progress through a cycle that consists of phases for growth (blue, green, yellow) and division (red). Cells become quiescent when they exit this cycle (purple). Crabtree + Company View Media
Magnesium transporter protein from E. faecalis
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Structure of a magnesium transporter protein from an antibiotic-resistant bacterium (Enterococcus faecalis) found in the human gut. New York Structural GenomiX Consortium View Media
NCMIR Tongue 2
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Microscopy image of a tongue. One in a series of two, see image 5810 National Center for Microscopy and Imaging Research (NCMIR) View Media
Kupffer cell residing in the liver
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Kupffer cells appear in the liver during the early stages of mammalian development and stay put throughout life to protect liver cells, clean up old red blood cells, and regulate iron levels. Thomas Deerinck, National Center for Microscopy and Imaging Research, University of California, San Diego. View Media
Sortase b from B. anthracis
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Structure of sortase b from the bacterium B. anthracis, which causes anthrax. Sortase b is an enzyme used to rob red blood cells of iron, which the bacteria need to survive. Midwest Center for Structural Genomics, PSI View Media
DNase
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Crystals of DNase protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Bacterial cells migrating through the tissues of the squid light organ
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Vibrio fischeri cells (~ 2 mm), labeled with green fluorescent protein (GFP), passing through a very narrow bottleneck in the tissues (red) of the Hawaiian bobtail squid, Euprymna scolope Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Research mentor and student
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A research mentor (Lori Eidson) and student (Nina Waldron, on the microscope) were 2009 members of the BRAIN (Behavioral Research Advancements In Neuroscience) program at Georgia State University in A Elizabeth Weaver, Georgia State University View Media
Natcher Building 04
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NIGMS staff are located in the Natcher Building on the NIH campus. Alisa Machalek, National Institute of General Medical Sciences View Media
Protein from Arabidopsis thaliana
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NMR solution structure of a plant protein that may function in host defense. This protein was expressed in a convenient and efficient wheat germ cell-free system. Center for Eukaryotic Structural Genomics View Media
Induced stem cells from adult skin 01
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These cells are induced stem cells made from human adult skin cells that were genetically reprogrammed to mimic embryonic stem cells. James Thomson, University of Wisconsin-Madison View Media
G switch (with labels and stages)
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The G switch allows our bodies to respond rapidly to hormones. G proteins act like relay batons to pass messages from circulating hormones into cells. Crabtree + Company View Media
Automated crystal screening system
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Automated crystal screening systems such as the one shown here are becoming a common feature at synchrotron and other facilities where high-throughput crystal structure determination is being carried Southeast Collaboratory for Structural Genomics View Media
The eye uses many layers of nerve cells to convert light into sight
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This image captures the many layers of nerve cells in the retina. The top layer (green) is made up of cells called photoreceptors that convert light into electrical signals to relay to the brain. Wei Li, National Eye Institute, National Institutes of Health View Media
Transmission electron microscopy showing cross-section of the node of Ranvier
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Nodes of Ranvier are short gaps in the myelin sheath surrounding myelinated nerve cells (axons). Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
