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Automated crystal screening system
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Automated crystal screening systems such as the one shown here are becoming a common feature at synchrotron and other facilities where high-throughput crystal structure determination is being carried Southeast Collaboratory for Structural Genomics View Media
Morphine Structure
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The chemical structure of the morphine molecule Judy Coyle, Donald Danforth Plant Science Center View Media
Rhodopsin bound to visual arrestin
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Rhodopsin is a pigment in the rod cells of the retina (back of the eye). It is extremely light-sensitive, supporting vision in low-light conditions. Protein Data Bank. View Media
Hsp33 figure 2
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Featured in the March 15, 2012 issue of Biomedical Beat. Related to Hsp33 Figure 1, image 3354. Ursula Jakob and Dana Reichmann, University of Michigan View Media
An adult Hawaiian bobtail squid
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An adult female Hawaiian bobtail squid, Euprymna scolopes, with its mantle cavity exposed from the underside. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
The Structure of Cilia’s Doublet Microtubules
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Cilia (cilium in singular) are complex molecular machines found on many of our cells. Brown Lab, Harvard Medical School and Veronica Falconieri Hays View Media
Actin filaments bundled around the dynamin helical polymer
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Multiple actin filaments (magenta) are organized around a dynamin helical polymer (rainbow colored) in this model derived from cryo-electron tomography. Elizabeth Chen, University of Texas Southwestern Medical Center. View Media
Salivary gland in the developing fruit fly
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For fruit flies, the salivary gland is used to secrete materials for making the pupal case, the protective enclosure in which a larva transforms into an adult fly. Richard Fehon, University of Chicago View Media
Zika virus
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Zika virus is shown in cross section at center left. On the outside, it includes envelope protein (red) and membrane protein (magenta) embedded in a lipid membrane (light purple). Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
DNA replication origin recognition complex (ORC)
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A study published in March 2012 used cryo-electron microscopy to determine the structure of the DNA replication origin recognition complex (ORC), a semi-circular, protein complex (yellow) that recogni Huilin Li, Brookhaven National Laboratory View Media
RSV-Infected Cell
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Viral RNA (red) in an RSV-infected cell. Eric Alonas and Philip Santangelo, Georgia Institute of Technology and Emory University View Media
Flagellated bacterial cells
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Vibrio fischeri (2 mm in length) is the exclusive symbiotic partner of the Hawaiian bobtail squid, Euprymna scolopes. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Molecules blocking Huntington's protein production
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The molecules that glow blue in these cultured cells prevent the expression of the mutant proteins that cause Huntington's disease. Jiaxin Hu, David W. Dodd and Robert H. E. Hudson, UT Southwestern Medical Center View Media
Induced pluripotent stem cells from skin
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These induced pluripotent stem cells (iPS cells) were derived from a woman's skin. Green and red indicate proteins found in reprogrammed cells but not in skin cells (TRA1-62 and NANOG). Kathrin Plath lab, University of California, Los Angeles, via CIRM View Media
Rabbit GPDA
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A crystal of rabbit GPDA protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
NCMIR Tongue 2
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Microscopy image of a tongue. One in a series of two, see image 5810 National Center for Microscopy and Imaging Research (NCMIR) View Media
Precise development in the fruit fly embryo
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This 2-hour-old fly embryo already has a blueprint for its formation, and the process for following it is so precise that the difference of just a few key molecules can change the plans. Thomas Gregor, Princeton University View Media
Anti-tumor drug ecteinascidin 743 (ET-743), structure without hydrogens 01
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Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, Ecteinascidia turbinata, by NIGMS grantee Kenneth Rinehart at the University of Illinois. Timothy Jamison, Massachusetts Institute of Technology View Media
Cryo-ET cell cross-section visualizing insulin vesicles
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On the left, a cross-section slice of a rat pancreas cell captured using cryo-electron tomography (cryo-ET). On the right, a color-coded, 3D version of the image highlighting cell structures. Xianjun Zhang, University of Southern California. View Media
Cerebellum: the brain's locomotion control center
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The cerebellum of a mouse is shown here in cross-section. The cerebellum is the brain's locomotion control center. Thomas Deerinck, National Center for Microscopy and Imaging Research, University of California, San Diego View Media
Microtubule growth
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Map of microtubule growth rates. Rates are color coded. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View Media
Stress Response in Cells
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Two highly stressed osteosarcoma cells are shown with a set of green droplet-like structures followed by a second set of magenta droplets. Julia F. Riley and Carlos A. Castañeda, Syracuse University View Media
Petri dish containing C. elegans
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This Petri dish contains microscopic roundworms called Caenorhabditis elegans. Researchers used these particular worms to study how C. H. Robert Horvitz and Dipon Ghosh, Massachusetts Institute of Technology. View Media
Beaded bacteriophage
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This sculpture made of purple and clear glass beads depicts bacteriophage Phi174, a virus that infects bacteria. It rests on a surface that portrays an adaptive landscape, a conceptual visualization. Holly Wichman, University of Idaho. (Surface by A. Johnston; photo by J. Palmersheim) View Media
Mitosis - anaphase
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A cell in anaphase during mitosis: Chromosomes separate into two genetically identical groups and move to opposite ends of the spindle. Judith Stoffer View Media
Telomeres on outer edge of nucleus during cell division
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New research shows telomeres moving to the outer edge of the nucleus after cell division, suggesting these caps that protect chromosomes also may play a role in organizing DNA. Laure Crabbe, Jamie Kasuboski and James Fitzpatrick, Salk Institute for Biological Studies View Media
Drosophila
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Two adult fruit flies (Drosophila) Dr. Vicki Losick, MDI Biological Laboratory, www.mdibl.org View Media
Zebrafish pigment cell
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Pigment cells are cells that give skin its color. David Parichy, University of Washington View Media
Sponge
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Many of today's medicines come from products found in nature, such as this sponge found off the coast of Palau in the Pacific Ocean. Phil Baran, Scripps Research Institute View Media
Z rings in bacterial division
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Lab-made liposomes contract where Z rings have gathered together and the constriction forces are greatest (arrows). Masaki Osawa, Duke University View Media
Animal cell
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A typical animal cell, sliced open to reveal a cross-section of organelles. Judith Stoffer View Media
Bicycling cell
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A humorous treatment of the concept of a cycling cell. Judith Stoffer View Media
Cells frozen in time
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The fledgling field of X-ray microscopy lets researchers look inside whole cells rapidly frozen to capture their actions at that very moment. Here, a yeast cell buds before dividing into two. Carolyn Larabell, University of California, San Francisco, and the Lawrence Berkeley National Laboratory View Media
Arabidopsis Thaliana: Flowers Spring to Life
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This image capture shows how a single gene, STM, plays a starring role in plant development. Nathanaёl Prunet NIH Support: National Institute of General Medical Sciences View Media
Calcium uptake during ATP production in mitochondria
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Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (blue) are stained with DAPI. Lili Guo, Perelman School of Medicine, University of Pennsylvania View Media
Neural circuits in worms similar to those in humans
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Green and yellow fluorescence mark the processes and cell bodies of some C. elegans neurons. Shawn Xu, University of Michigan View Media
Tracking cells in a gastrulating zebrafish embryo
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During development, a zebrafish embryo is transformed from a ball of cells into a recognizable body plan by sweeping convergence and extension cell movements. This process is called gastrulation. Liliana Solnica-Krezel, Washington University School of Medicine in St. Louis. View Media
RNA polymerase
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RNA polymerase (purple) is a complex enzyme at the heart of transcription. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Jack bean concanavalin A
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Crystals of jack bean concanavalin A protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Yeast cells with Fimbrin Fim1
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Yeast cells with the protein Fimbrin Fim1 shown in magenta. This protein plays a role in cell division. This image was captured using wide-field microscopy with deconvolution.Alaina Willet, Kathy Gould’s lab, Vanderbilt University. View Media
Self-organizing proteins
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Under the microscope, an E. coli cell lights up like a fireball. Each bright dot marks a surface protein that tells the bacteria to move toward or away from nearby food and toxins. View Media
3-D Architecture of a Synapse
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This image shows the structure of a synapse, or junction between two nerve cells in three dimensions. From the brain of a mouse. Anton Maximov, The Scripps Research Institute, La Jolla, CA View Media
Regenerating lizard tail
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The interior of a regenerating lizard tail 14 days after the original tail was amputated. Thomas Lozito, University of Southern California. View Media
Chromosomes before crossing over
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Duplicated pair of chromosomes lined up and ready to cross over. Judith Stoffer View Media
Cell-like compartments from frog eggs 6
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Cell-like compartments that spontaneously emerged from scrambled frog eggs, with nuclei (blue) from frog sperm. Endoplasmic reticulum (red) and microtubules (green) are also visible. Xianrui Cheng, Stanford University School of Medicine. View Media
Glucose and sucrose
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Glucose (top) and sucrose (bottom) are sugars made of carbon, hydrogen, and oxygen atoms. Carbohydrates include simple sugars like these and are the main source of energy for the human body. Crabtree + Company View Media
Nucleotides make up DNA
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DNA consists of two long, twisted chains made up of nucleotides. Each nucleotide contains one base, one phosphate molecule, and the sugar molecule deoxyribose. Crabtree + Company View Media
Cells lining the trachea
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In this image, viewed with a ZEISS ORION NanoFab microscope, the community of cells lining a mouse airway is magnified more than 10,000 times. Eva Mutunga and Kate Klein, University of the District of Columbia and National Institute of Standards and Technology View Media
