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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 3
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media
Mitochondria from rat heart muscle cell_2
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These mitochondria (brown) are from the heart muscle cell of a rat. Mitochondria have an inner membrane that folds in many places (and that appears here as striations). National Center for Microscopy and Imaging Research View Media
Structure of telomerase
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Scientists recently discovered the full molecular structure of telomerase, an enzyme important to aging and cancer. Jiansen Jiang, Edward J. Miracco, Z. Hong Zhou and Juli Feigon, University of California, Los Angeles; Kathleen Collins, University of California, Berkeley View Media
Four timepoints in gastrulation
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It has been said that gastrulation is the most important event in a person's life. Bob Goldstein, University of North Carolina, Chapel Hill View Media
Dicty fruit
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Dictyostelium discoideum is a microscopic amoeba. A group of 100,000 form a mound as big as a grain of sand. Featured in The New Genetics. View Media
Endoplasmic reticulum abnormalities
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Human cells with the gene that codes for the protein FIT2 deleted. Green indicates an endoplasmic reticulum (ER) resident protein. Michel Becuwe, Harvard University. View Media
Mitosis - prometaphase
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A cell in prometaphase during mitosis: The nuclear membrane breaks apart, and the spindle starts to interact with the chromosomes. Judith Stoffer View Media
Smooth muscle from human ES cells
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These smooth muscle cells were derived from human embryonic stem cells. The nuclei are stained blue, and the proteins of the cytoskeleton are stained green. Alexey Terskikh lab, Burnham Institute for Medical Research, via CIRM View Media
Lily mitosis 02
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A light microscope image of a cell from the endosperm of an African globe lily (Scadoxus katherinae). This is one frame of a time-lapse sequence that shows cell division in action. Andrew S. Bajer, University of Oregon, Eugene View Media
Small blood vessels in a mouse retina
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Blood vessels at the back of the eye (retina) are used to diagnose glaucoma and diabetic eye disease. They also display characteristic changes in people with high blood pressure. National Center for Microscopy and Imaging Research View Media
Section of an electron density map
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Electron density maps such as this one are generated from the diffraction patterns of X-rays passing through protein crystals. The Southeast Collaboratory for Structural Genomics View Media
Aging book of life
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Damage to each person's genome, often called the "Book of Life," accumulates with time. Judith Stoffer View Media
Cancer Cells Glowing from Luciferin
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The activator cancer cell culture, right, contains a chemical that causes the cells to emit light when in the presence of immune cells. Mark Sellmyer, Stanford University School of Medicine View Media
3D reconstruction of the Golgi apparatus in a pancreas cell
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Researchers used cryo-electron tomography (cryo-ET) to capture images of a rat pancreas cell that were then compiled and color-coded to produce a 3D reconstruction. Xianjun Zhang, University of Southern California. View Media
Fused, dicentric chromosomes
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This fused chromosome has two functional centromeres, shown as two sets of red and green dots. Beth A. Sullivan, Duke University View Media
Worm sperm
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To develop a system for studying cell motility in unnatrual conditions -- a microscope slide instead of the body -- Tom Roberts and Katsuya Shimabukuro at Florida State University disassembled and rec Tom Roberts, Florida State University View Media
Q fever bacteria in an infected cell
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This image shows Q fever bacteria (yellow), which infect cows, sheep, and goats around the world and can infect humans, as well. When caught early, Q fever can be cured with antibiotics. Robert Heinzen, Elizabeth Fischer, and Anita Mora, National Institute of Allergy and Infectious Diseases, National Institutes of Health View Media
Virtual snow world
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Glide across an icy canyon, where you see smiling snowmen and waddling penguins. Toss a snowball, hear it smash against an igloo, and then watch it explode in bright colors. David Patterson and Hunter Hoffmann, University of Washington View Media
A molecular switch strips transcription factor from DNA
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In this video, Rice University scientists used molecular modeling with a mathematical algorithm called AWSEM (for associative memory, water-mediated, structure and energy model) and structural data to Davit Potoyan and Peter Wolynes View Media
Life of an AIDS virus (with labels)
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HIV is a retrovirus, a type of virus that carries its genetic material not as DNA but as RNA. Crabtree + Company View Media
Independence Day
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This graphic that resembles a firework was created from a picture of a fruit fly spermatid. Sigi Benjamin-Hong, Rockefeller University View Media
TEM cross-section of C. elegans (roundworm)
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The worm Caenorhabditis elegans is a popular laboratory animal because its small size and fairly simple body make it easy to study. Piali Sengupta, Brandeis University View Media
Computer algorithm
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This computer algorithm plots all feasible small carbon-based molecules as though they were cities on a map and identifies huge, unexplored spaces that may help fuel research into new drug therapies. Aaron Virshup, Julia Contreras-Garcia, Peter Wipf, Weitao Yang and David Beratan, University of Pittsburgh Center for Chemical Methodologies and Library Development View Media
Nucleotides make up DNA
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DNA consists of two long, twisted chains made up of nucleotides. Each nucleotide contains one base, one phosphate molecule, and the sugar molecule deoxyribose. Crabtree + Company View Media
Zinc finger
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The structure of a gene-regulating zinc finger protein bound to DNA. Jeremy M. Berg, National Institute of General Medical Sciences View Media
RNA Polymerase II
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NIGMS-funded researchers led by Roger Kornberg solved the structure of RNA polymerase II. David Bushnell, Ken Westover and Roger Kornberg, Stanford University View Media
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 2
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media
Yeast cells pack a punch
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Although they are tiny, microbes that are growing in confined spaces can generate a lot of pressure. In this video, yeast cells grow in a small chamber called a microfluidic bioreactor. Oskar Hallatschek, UC Berkeley View Media
Mouse embryo showing Smad4 protein
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This eerily glowing blob isn't an alien or a creature from the deep sea--it's a mouse embryo just eight and a half days old. The green shell and core show a protein called Smad4. Kenneth Zaret, Fox Chase Cancer Center View Media
Retinal pigment epithelium derived from human ES cells 02
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This image shows a layer of retinal pigment epithelium cells derived from human embryonic stem cells, highlighting the nuclei (red) and cell surfaces (green). David Buckholz and Sherry Hikita, University of California, Santa Barbara, via CIRM View Media
Early life of a protein
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This illustration represents the early life of a protein—specifically, apomyoglobin—as it is synthesized by a ribosome and emerges from the ribosomal tunnel, which contains the newly formed protein's Silvia Cavagnero, University of Wisconsin, Madison View Media
Activation energy
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To become products, reactants must overcome an energy hill. See image 2526 for a labeled version of this illustration. Featured in The Chemistry of Health. Crabtree + Company View Media
Bond types
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Ionic and covalent bonds hold molecules, like sodium chloride and chlorine gas, together. Hydrogen bonds among molecules, notably involving water, also play an important role in biology. Crabtree + Company View Media
Alternative splicing
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Arranging exons in different patterns, called alternative splicing, enables cells to make different proteins from a single gene. Crabtree + Company View Media
Wound healing in process
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Wound healing requires the action of stem cells. Hermann Steller, Rockefeller University View Media
Advanced Photon Source (APS) at Argonne National Lab
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The intense X-rays produced by synchrotrons such as the Advanced Photon Source are ideally suited for protein structure determination. Southeast Collaboratory for Structural Genomics View Media
Measles virus
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A cross section of the measles virus in which six proteins work together to infect cells. The measles virus is extremely infectious; 9 out of 10 people exposed will contract the disease. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
HeLa cells
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Multiphoton fluorescence image of cultured HeLa cells with a fluorescent protein targeted to the Golgi apparatus (orange), microtubules (green) and counterstained for DNA (cyan). National Center for Microscopy and Imaging Research (NCMIR) View Media
Histone deacetylases
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The human genome contains much of the information needed for every cell in the body to function. However, different types of cells often need different types of information. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Crystals of CCD-1 in complex with cefotaxime
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CCD-1 is an enzyme produced by the bacterium Clostridioides difficile that helps it resist antibiotics. Keith Hodgson, Stanford University. View Media
Disease-susceptible Arabidopsis leaf
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This is a magnified view of an Arabidopsis thaliana leaf after several days of infection with the pathogen Hyaloperonospora arabidopsidis. Jeff Dangl, University of North Carolina, Chapel Hill View Media
Cell toxins
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A number of environmental factors cause DNA mutations that can lead to cancer: toxins in cigarette smoke, sunlight and other radiation, and some viruses. Judith Stoffer View Media
Pigment cells in the fin of pearl danio
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Pigment cells are cells that give skin its color. David Parichy, University of Washington View Media
Human ES cells differentiating into neurons
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This image shows hundreds of human embryonic stem cells in various stages of differentiating into neurons. Guoping Fan lab, University of California, Los Angeles, via CIRM View Media
Magnesium transporter protein from E. faecalis
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Structure of a magnesium transporter protein from an antibiotic-resistant bacterium (Enterococcus faecalis) found in the human gut. New York Structural GenomiX Consortium View Media
Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 2
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Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. Matthew West and Greg Odorizzi, University of Colorado View Media
Color coding of the Drosophila brain - video
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This video results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. Yong Wan from Charles Hansen’s lab, University of Utah. Data preparation and visualization by Masayoshi Ito in the lab of Kei Ito, University of Tokyo. View Media
Aminopeptidase N from N. meningitidis
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Model of the enzyme aminopeptidase N from the human pathogen Neisseria meningitidis, which can cause meningitis epidemics. Midwest Center for Structural Genomics, PSI View Media
High-throughput protein structure determination pipeline
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This slide shows the technologies that the Joint Center for Structural Genomics developed for going from gene to structure and how the technologies have been integrated into a high-throughput pipeline Joint Center for Structural Genomics View Media
