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Plant resistosome
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The research organism Arabidopsis thaliana forms a large molecular machine called a resistosome to fight off infections. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Brains of sleep-deprived and well-rested fruit flies
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On top, the brain of a sleep-deprived fly glows orange because of Bruchpilot, a communication protein between brain cells. These bright orange brain areas are associated with learning. Chiara Cirelli, University of Wisconsin-Madison View Media
Autofluorescent xanthophores in zebrafish skin
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Pigment cells are cells that give skin its color. David Parichy, University of Washington View Media
CRISPR Illustration Frame 1
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This illustration shows, in simplified terms, how the CRISPR-Cas9 system can be used as a gene-editing tool. This is the first frame in a series of four. National Institute of General Medical Sciences. View Media
Network Map
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This network map shows the overlap (green) between the long QT syndrome (yellow) and epilepsy (blue) protein-interaction neighborhoods located within the human interactome. Seth Berger, Mount Sinai School of Medicine View Media
Disease-resistant Arabidopsis leaf
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This is a magnified view of an Arabidopsis thaliana leaf a few days after being exposed to the pathogen Hyaloperonospora arabidopsidis. Jeff Dangl, University of North Carolina, Chapel Hill View Media
Chromatin in human fibroblast
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The nucleus of a human fibroblast cell with chromatin—a substance made up of DNA and proteins—shown in various colors. Melike Lakadamyali, Perelman School of Medicine at the University of Pennsylvania. View Media
Natcher Building 06
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NIGMS staff are located in the Natcher Building on the NIH campus. Alisa Machalek, National Institute of General Medical Sciences View Media
Developing nerve cells
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These developing mouse nerve cells have a nucleus (yellow) surrounded by a cell body, with long extensions called axons and thin branching structures called dendrites. Torsten Wittmann, University of California, San Francisco View Media
HIV enzyme
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These images model the molecular structures of three enzymes with critical roles in the life cycle of the human immunodeficiency virus (HIV). Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Oligoendopeptidase F from B. stearothermophilus
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Crystal structure of oligoendopeptidase F, a protein slicing enzyme from Bacillus stearothermophilus, a bacterium that can cause food products to spoil. Accelerated Technologies Center for Gene to 3D Structure/Midwest Center for Structural Genomics View Media
Fly by night
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This fruit fly expresses green fluorescent protein (GFP) in the same pattern as the period gene, a gene that regulates circadian rhythm and is expressed in all sensory neurons on the surface of the fl Jay Hirsh, University of Virginia View Media
Axolotl
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An axolotl—a type of salamander—that has been genetically modified so that its developing nervous system glows purple and its Schwann cell nuclei appear light blue. Prayag Murawala, MDI Biological Laboratory and Hannover Medical School. View Media
Computer sketch of bird-and-flower DNA origami
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A computer-generated sketch of a DNA origami folded into a flower-and-bird structure. See also related image 3690. Hao Yan, Arizona State University View Media
VDAC-1 (1)
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The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View Media
Ribonuclease P structure
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Ribbon diagram showing the structure of Ribonuclease P with tRNA. PDB entry 3Q1Q, molecular modeling by Fred Friedman, NIGMS View Media
Pathways – Bacteria vs. Viruses: What's the Difference?
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Learn about how bacteria and viruses differ, how they each can make you sick, and how they can or cannot be treated. National Institute of General Medical Sciences View Media
RNA Polymerase II
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NIGMS-funded researchers led by Roger Kornberg solved the structure of RNA polymerase II. David Bushnell, Ken Westover and Roger Kornberg, Stanford University View Media
Misfolded proteins in mitochondria, 3-D video
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Three-dimensional image of misfolded proteins (green) within mitochondria (red). Related to image 5878. Rong Li, Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University View Media
Microscopy image of bird-and-flower DNA origami
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An atomic force microscopy image shows DNA folded into an intricate, computer-designed structure. Hao Yan, Arizona State University View Media
Polarized cells- 01
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Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Rong Li and Praveen Suraneni, Stowers Institute for Medical Research View Media
Nucleolus subcompartments spontaneously self-assemble 4
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What looks a little like distant planets with some mysterious surface features are actually assemblies of proteins normally found in the cell's nucleolus, a small but very important protein complex lo Nilesh Vaidya, Princeton University View Media
Structure of heme, top view
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Molecular model of the struture of heme. Heme is a small, flat molecule with an iron ion (dark red) at its center. Rachel Kramer Green, RCSB Protein Data Bank View Media
Electrostatic map of the adeno-associated virus with scale
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The new highly efficient parallelized DelPhi software was used to calculate the potential map distribution of an entire virus, the adeno-associated virus, which is made up of more than 484,000 atoms. Emil Alexov, Clemson University View Media
Snowflake yeast 3
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Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. William Ratcliff, Georgia Institute of Technology. View Media
Cone cell
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The cone cell of the eye allows you to see in color. Appears in the NIGMS booklet Inside the Cell. Judith Stoffer View Media
Petri dish containing C. elegans
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This Petri dish contains microscopic roundworms called Caenorhabditis elegans. Researchers used these particular worms to study how C. H. Robert Horvitz and Dipon Ghosh, Massachusetts Institute of Technology. View Media
High-throughput protein structure determination pipeline
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This slide shows the technologies that the Joint Center for Structural Genomics developed for going from gene to structure and how the technologies have been integrated into a high-throughput pipeline Joint Center for Structural Genomics View Media
C. elegans showing internal structures
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An image of Caenorhabditis elegans, a tiny roundworm, showing internal structures including the intestine, pharynx, and body wall muscle. C. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media
Pig trypsin crystal
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A crystal of pig trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Biopixels
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Bioengineers were able to coax bacteria to blink in unison on microfluidic chips. This image shows a small chip with about 500 blinking bacterial colonies or biopixels. Jeff Hasty Lab, UC San Diego View Media
Beta2-adrenergic receptor protein
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Crystal structure of the beta2-adrenergic receptor protein. The Stevens Laboratory, The Scripps Research Institute View Media
Protein kinases as cancer chemotherapy targets
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Protein kinases—enzymes that add phosphate groups to molecules—are cancer chemotherapy targets because they play significant roles in almost all aspects of cell function, are tightly regulated, and co Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Quorum-sensing inhibitor limits bacterial growth
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To simulate the consequences of disrupting bacterial cell-to-cell communication, called quorum sensing, in the crypts (small chambers within the colon), the researchers experimented with an inhibitor Minyoung Kevin Kim and Bonnie Bassler, Princeton University View Media
Computer algorithm
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This computer algorithm plots all feasible small carbon-based molecules as though they were cities on a map and identifies huge, unexplored spaces that may help fuel research into new drug therapies. Aaron Virshup, Julia Contreras-Garcia, Peter Wipf, Weitao Yang and David Beratan, University of Pittsburgh Center for Chemical Methodologies and Library Development View Media
Chromosome inside nucleus
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The long, stringy DNA that makes up genes is spooled within chromosomes inside the nucleus of a cell. Crabtree + Company View Media
Polarized cells- 02
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Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Rong Li and Praveen Suraneni, Stowers Institute for Medical Research View Media
Microtubule growth
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Map of microtubule growth rates. Rates are color coded. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View Media
Bacteriophage P22 capsid, detail
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Detail of a subunit of the capsid, or outer cover, of bacteriophage P22, a virus that infects the Salmonella bacteria. Dr. Wah Chiu, Baylor College of Medicine View Media
Nerve ending
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A scanning electron microscope picture of a nerve ending. It has been broken open to reveal vesicles (orange and blue) containing chemicals used to pass messages in the nervous system. Tina Weatherby Carvalho, University of Hawaii at Manoa View Media
Weblike sheath covering developing egg chambers in a giant grasshopper
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The lubber grasshopper, found throughout the southern United States, is frequently used in biology classes to teach students about the respiratory system of insects. Kevin Edwards, Johny Shajahan, and Doug Whitman, Illinois State University. View Media
Mouse brain slice showing nerve cells
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A 20-µm thick section of mouse midbrain. The nerve cells are transparent and weren’t stained. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media
2-D NMR
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A two-dimensional NMR spectrum of a protein, in this case a 2D 1H-15N HSQC NMR spectrum of a 228 amino acid DNA/RNA-binding protein. Dr. Xiaolian Gao's laboratory at the University of Houston View Media
Carbon building blocks (with examples)
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The arrangement of identical molecular components can make a dramatic difference. For example, carbon atoms can be arranged into dull graphite (left) or sparkly diamonds (right). Crabtree + Company View Media
Xenopus laevis egg
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Xenopus laevis, the African clawed frog, has long been used as a model organism for studying embryonic development. Michael Klymkowsky, University of Colorado, Boulder View Media
Ciclo circadiano de un adolescente típico
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Los ritmos circadianos son cambios físicos, mentales y conductuales que siguen un ciclo de 24 horas. NIGMS View Media
Z rings in bacterial division
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Lab-made liposomes contract where Z rings have gathered together and the constriction forces are greatest (arrows). Masaki Osawa, Duke University View Media
Yeast cells with nuclear envelopes and tubulin
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Yeast cells with nuclear envelopes shown in magenta and tubulin shown in light blue. The nuclear envelope defines the borders of the nucleus, which houses DNA. Alaina Willet, Kathy Gould’s lab, Vanderbilt University. View Media
Nuclear Lamina – Three Views
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Three views of the entire nuclear lamina of a HeLa cell produced by tilted light sheet 3D single-molecule super-resolution imaging using a platform termed TILT3D. Anna-Karin Gustavsson, Ph.D. View Media
