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This is a searchable collection of scientific photos, illustrations, and videos. The images and videos in this gallery are licensed under Creative Commons Attribution Non-Commercial ShareAlike 3.0. This license lets you remix, tweak, and build upon this work non-commercially, as long as you credit and license your new creations under identical terms.
Ubiquitin-fold modifier 1 from C. elegans
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Solution NMR structure of protein target WR41 (left) from C. elegans. Northeast Structural Genomics Consortium View Media
Pulsating response to stress in bacteria - video
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By attaching fluorescent proteins to the genetic circuit responsible for B. subtilis's stress response, researchers can observe the cells' pulses as green flashes. Michael Elowitz, Caltech University View Media
Natcher Building 09
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NIGMS staff are located in the Natcher Building on the NIH campus. Alisa Machalek, National Institute of General Medical Sciences View Media
Fruit fly spermatids
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Developing spermatids (precursors of mature sperm cells) begin as small, round cells and mature into long-tailed, tadpole-shaped ones. Lacramioara Fabian, The Hospital for Sick Children, Toronto, Canada View Media
Developing nerve cells
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These developing mouse nerve cells have a nucleus (yellow) surrounded by a cell body, with long extensions called axons and thin branching structures called dendrites. Torsten Wittmann, University of California, San Francisco View Media
Retinal pigment epithelium derived from human ES cells 02
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This image shows a layer of retinal pigment epithelium cells derived from human embryonic stem cells, highlighting the nuclei (red) and cell surfaces (green). David Buckholz and Sherry Hikita, University of California, Santa Barbara, via CIRM View Media
Pig trypsin (3)
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Crystals of porcine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
ATP Synthase
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Atomic model of the membrane region of the mitochondrial ATP synthase built into a cryo-EM map at 3.6 Å resolution. ATP synthase is the primary producer of ATP in aerobic cells. Bridget Carragher, <a href="http://nramm.nysbc.org/">NRAMM National Resource for Automated Molecular Microscopy</a> View Media
A bundle of myelinated peripheral nerve cells (axons)
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The extracellular matrix (ECM) is most prevalent in connective tissues but also is present between the stems (axons) of nerve cells. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Confocal microscopy of perineuronal nets in the brain 1
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The photo shows a confocal microscopy image of perineuronal nets (PNNs), which are specialized extracellular matrix (ECM) structures in the brain. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Glowing bacteria make a pretty postcard
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This tropical scene, reminiscent of a postcard from Key West, is actually a petri dish containing an artistic arrangement of genetically engineered bacteria. Nathan C. Shaner, The Scintillon Institute View Media
Neural circuits in worms similar to those in humans
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Green and yellow fluorescence mark the processes and cell bodies of some C. elegans neurons. Shawn Xu, University of Michigan View Media
Alternative splicing (with labels)
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Arranging exons in different patterns, called alternative splicing, enables cells to make different proteins from a single gene. Featured in The New Genetics. Crabtree + Company View Media
RNA strand (with labels)
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Ribonucleic acid (RNA) has a sugar-phosphate backbone and the bases adenine (A), cytosine (C), guanine (G), and uracil (U). Featured in The New Genetics. Crabtree + Company View Media
HIV Capsid
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This image is a computer-generated model of the approximately 4.2 million atoms of the HIV capsid, the shell that contains the virus' genetic material. Juan R. Perilla and the Theoretical and Computational Biophysics Group, University of Illinois at Urbana-Champaign View Media
Simulation of controlled avian flu outbreak
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This video shows a controlled outbreak of transmissible avian flu among people living in Thailand. Neil M. Ferguson, Imperial College London View Media
Fruit fly egg ooplasmic streaming
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Two fruit fly (Drosophila melanogaster) egg cells, one on each side of the central black line. Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View Media
Cytoscape network diagram 1
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Molecular biologists are increasingly relying on bioinformatics software to visualize molecular interaction networks and to integrate these networks with data such as gene expression profiles. Keiichiro Ono, Trey Ideker lab, University of California, San Diego View Media
Tracking embryonic zebrafish cells
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To better understand cell movements in developing embryos, researchers isolated cells from early zebrafish embryos and grew them as clusters. Liliana Solnica-Krezel, Washington University School of Medicine in St. Louis. View Media
Mapping disease spread
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How far and fast an infectious disease spreads across a community depends on many factors, including transportation. These U.S. David Chrest, RTI International View Media
String-like Ebola virus peeling off an infected cell
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After multiplying inside a host cell, the stringlike Ebola virus is emerging to infect more cells. Heinz Feldmann, Peter Jahrling, Elizabeth Fischer and Anita Mora, National Institute of Allergy and Infectious Diseases, National Institutes of Health View Media
Color coding of the Drosophila brain - black background
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This image results from a research project to visualize which regions of the adult fruit fly (Drosophila) brain derive from each neural stem cell. Yong Wan from Charles Hansen’s lab, University of Utah. Data preparation and visualization by Masayoshi Ito in the lab of Kei Ito, University of Tokyo. View Media
Cell toxins
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A number of environmental factors cause DNA mutations that can lead to cancer: toxins in cigarette smoke, sunlight and other radiation, and some viruses. Judith Stoffer View Media
Hawaiian bobtail squid
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An adult Hawaiian bobtail squid, Euprymna scolopes, swimming next to a submerged hand. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Pig trypsin (1)
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A crystal of porcine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Computer algorithm
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This computer algorithm plots all feasible small carbon-based molecules as though they were cities on a map and identifies huge, unexplored spaces that may help fuel research into new drug therapies. Aaron Virshup, Julia Contreras-Garcia, Peter Wipf, Weitao Yang and David Beratan, University of Pittsburgh Center for Chemical Methodologies and Library Development View Media
Adult Hawaiian bobtail squid burying in the sand
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Each morning, the nocturnal Hawaiian bobtail squid, Euprymna scolopes, hides from predators by digging into the sand. At dusk, it leaves the sand again to hunt. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Master clock of the mouse brain
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An image of the area of the mouse brain that serves as the 'master clock,' which houses the brain's time-keeping neurons. The nuclei of the clock cells are shown in blue. Erik Herzog, Washington University in St. Louis View Media
HIV-1 virus in the colon
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A tomographic reconstruction of the colon shows the location of large pools of HIV-1 virus particles (in blue) located in the spaces between adjacent cells. Mark Ladinsky, California Institute of Technology View Media
Snowflake yeast 3
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Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. William Ratcliff, Georgia Institute of Technology. View Media
Drugs enter skin (with labels)
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Drugs enter different layers of skin via intramuscular, subcutaneous, or transdermal delivery methods. See image 2531 for an unlabeled version of this illustration. Crabtree + Company View Media
Hen egg lysozyme (2)
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A crystal of hen egg lysozyme protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Circadian rhythm neurons in the fruit fly brain
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Some nerve cells (neurons) in the brain keep track of the daily cycle. This time-keeping mechanism, called the circadian clock, is found in all animals including us. Justin Blau, New York University View Media
Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 2
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Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. Matthew West and Greg Odorizzi, University of Colorado View Media
Seeing signaling protein activation in cells 01
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Cdc42, a member of the Rho family of small guanosine triphosphatase (GTPase) proteins, regulates multiple cell functions, including motility, proliferation, apoptosis, and cell morphology. Klaus Hahn, University of North Carolina, Chapel Hill Medical School View Media
Cell cycle
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Cells progress through a cycle that consists of phases for growth (blue, green, yellow) and division (red). Cells become quiescent when they exit this cycle (purple). Crabtree + Company View Media
VDAC video 02
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This video shows the structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View Media
The 26S proteasome engages with a protein substrate
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The proteasome is a critical multiprotein complex in the cell that breaks down and recycles proteins that have become damaged or are no longer needed. Andreas Martin, HHMI View Media
Calcium uptake during ATP production in mitochondria
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Living primary mouse embryonic fibroblasts. Mitochondria (green) stained with the mitochondrial membrane potential indicator, rhodamine 123. Nuclei (blue) are stained with DAPI. Lili Guo, Perelman School of Medicine, University of Pennsylvania View Media
Apoptosis reversed
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Two healthy cells (bottom, left) enter into apoptosis (bottom, center) but spring back to life after a fatal toxin is removed (bottom, right; top). Hogan Tang of the Denise Montell Lab, Johns Hopkins University School of Medicine View Media
Fruit fly embryo
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Cells in an early-stage fruit fly embryo, showing the DIAP1 protein (pink), an inhibitor of apoptosis. Hermann Steller, Rockefeller University View Media
Mouse heart fibroblasts
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This image shows mouse fetal heart fibroblast cells. The muscle protein actin is stained red, and the cell nuclei are stained blue. Kara McCloskey lab, University of California, Merced, via CIRM View Media
Genetically identical mycobacteria respond differently to antibiotic 1
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Antibiotic resistance in microbes is a serious health concern. So researchers have turned their attention to how bacteria undo the action of some antibiotics. Bree Aldridge, Tufts University View Media
PanB from M. tuberculosis (1)
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Model of an enzyme, PanB, from Mycobacterium tuberculosis, the bacterium that causes most cases of tuberculosis. This enzyme is an attractive drug target. Mycobacterium Tuberculosis Center, PSI View Media
Cell division with late aligning chromosomes
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This video shows an instance of abnormal mitosis where chromosomes are late to align. Gary Gorbsky, Oklahoma Medical Research Foundation View Media
Modeling disease spread
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What looks like a Native American dream catcher is really a network of social interactions within a community. Stephen Eubank, University of Virginia Biocomplexity Institute (formerly Virginia Bioinformatics Institute) View Media
Bone cancer cell
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This image shows an osteosarcoma cell with DNA in blue, energy factories (mitochondria) in yellow, and actin filaments—part of the cellular skeleton—in purple. Dylan Burnette and Jennifer Lippincott-Schwartz, NICHD View Media
Structure of a key antigen protein involved with Hepatitis C Virus infection
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A three-dimensional representation of the structure of E2, a key antigen protein involved with hepatitis C virus infection. Mansun Law Associate Professor Department of Immunolgy and Microbial Science The Scripps Research Institute View Media
Anti-tumor drug ecteinascidin 743 (ET-743), structure without hydrogens 03
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Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, Ecteinascidia turbinata, by NIGMS grantee Kenneth Rinehart at the University of Illinois. Timothy Jamison, Massachusetts Institute of Technology View Media
