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Mandelate racemase from B. subtilis
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Model of the mandelate racemase enzyme from Bacillus subtilis, a bacterium commonly found in soil. New York Structural GenomiX Research Consortium, PSI View Media
TEM cross-section of C. elegans (roundworm)
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The worm Caenorhabditis elegans is a popular laboratory animal because its small size and fairly simple body make it easy to study. Piali Sengupta, Brandeis University View Media
Fluorescent E. coli bacteria
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Bioengineers were able to coax bacteria to blink in unison on microfluidic chips. They called each blinking bacterial colony a biopixel. Thousands of fluorescent E. Jeff Hasty Lab, UC San Diego View Media
Caulobacter
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A study using Caulobacter crescentus showed that some bacteria use just-in-time processing, much like that used in industrial delivery, to make the glue that allows them to attach to surfaces, Yves Brun, Indiana University View Media
Sleep and the fly brain
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In the top snapshots, the brain of a sleep-deprived fruit fly glows orange, marking high concentrations of a synaptic protein called Bruchpilot (BRP) involved in communication between neurons. Chiara Cirelli, University of Wisconsin-Madison View Media
X-ray crystallography
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X-ray crystallography allows researchers to see structures too small to be seen by even the most powerful microscopes. Crabtree + Company View Media
A molecular switch strips transcription factor from DNA
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In this video, Rice University scientists used molecular modeling with a mathematical algorithm called AWSEM (for associative memory, water-mediated, structure and energy model) and structural data to Davit Potoyan and Peter Wolynes View Media
Anti-tumor drug ecteinascidin 743 (ET-743), structure without hydrogens 04
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Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, Ecteinascidia turbinata, by NIGMS grantee Kenneth Rinehart at the University of Illinois. Timothy Jamison, Massachusetts Institute of Technology View Media
PanB from M. tuberculosis (2)
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Model of an enzyme, PanB, from Mycobacterium tuberculosis, the bacterium that causes most cases of tuberculosis. This enzyme is an attractive drug target. Mycobacterium Tuberculosis Center, PSI-1 View Media
Fruit fly embryo
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Cells in an early-stage fruit fly embryo, showing the DIAP1 protein (pink), an inhibitor of apoptosis. Hermann Steller, Rockefeller University View Media
Correlative imaging by annotation with single molecules (CIASM) process
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These images illustrate a technique combining cryo-electron tomography and super-resolution fluorescence microscopy called correlative imaging by annotation with single molecules (CIASM). Peter Dahlberg, Stanford University. View Media
Retroviruses as fossils
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DNA doesn't leave a fossil record in stone, the way bones do. Instead, the DNA code itself holds the best evidence for organisms' genetic history. Emily Harrington, science illustrator View Media
Meiosis illustration (with labels)
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Meiosis is the process whereby a cell reduces its chromosomes from diploid to haploid in creating eggs or sperm. Crabtree + Company View Media
HIV-1 virus in the colon
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A tomographic reconstruction of the colon shows the location of large pools of HIV-1 virus particles (in blue) located in the spaces between adjacent cells. Mark Ladinsky, California Institute of Technology View Media
Drosophila
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Two adult fruit flies (Drosophila) Dr. Vicki Losick, MDI Biological Laboratory, www.mdibl.org View Media
Bovine trypsin
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A crystal of bovine trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Los ritmos circadianos y el núcleo supraquiasmático
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Los ritmos circadianos son cambios físicos, mentales y de comportamiento que siguen un ciclo de 24 horas. NIGMS View Media
Multivesicular bodies containing intralumenal vesicles assemble at the vacuole 2
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Collecting and transporting cellular waste and sorting it into recylable and nonrecylable pieces is a complex business in the cell. Matthew West and Greg Odorizzi, University of Colorado View Media
Cisternae maturation model
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Animation for the cisternae maturation model of Golgi transport. Judith Stoffer View Media
Hydra 06
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Hydra magnipapillata is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis. Hiroshi Shimizu, National Institute of Genetics in Mishima, Japan View Media
Mapping metabolic activity
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Like a map showing heavily traveled roads, this mathematical model of metabolic activity inside an E. coli cell shows the busiest pathway in white. Albert-László Barabási, University of Notre Dame View Media
Anglerfish ovary cross-section
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This image captures the spiral-shaped ovary of an anglerfish in cross-section. Once matured, these eggs will be released in a gelatinous, floating mass. James E. Hayden, The Wistar Institute, Philadelphia, Pa. View Media
Cell cycle (with labels)
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Cells progress through a cycle that consists of phases for growth (G1, S, and G2) and division (M). Cells become quiescent when they exit this cycle (G0). Crabtree + Company View Media
Histones in chromatin
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Histone proteins loop together with double-stranded DNA to form a structure that resembles beads on a string. Crabtree + Company View Media
Aldolase
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2.5Å resolution reconstruction of rabbit muscle aldolase collected on a FEI/Thermo Fisher Titan Krios with energy filter and image corrector. National Resource for Automated Molecular Microscopy http://nramm.nysbc.org/nramm-images/ Source: Bridget Carragher View Media
Bacterial cells migrating through the tissues of the squid light organ
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Vibrio fischeri cells (~ 2 mm), labeled with green fluorescent protein (GFP), passing through a very narrow bottleneck in the tissues (red) of the Hawaiian bobtail squid, Euprymna scolope Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Protein purification robot in action 01
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A robot is transferring 96 purification columns to a vacuum manifold for subsequent purification procedures. The Northeast Collaboratory for Structural Genomics View Media
Yeast cell
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A whole yeast (Saccharomyces cerevisiae) cell viewed by X-ray microscopy. Inside, the nucleus and a large vacuole (red) are visible. Carolyn Larabell, University of California, San Francisco and the Lawrence Berkeley National Laboratory View Media
Misfolded proteins in mitochondria, 3-D video
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Three-dimensional image of misfolded proteins (green) within mitochondria (red). Related to image 5878. Rong Li, Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University View Media
dUTP pyrophosphatase from M. tuberculosis
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Model of an enzyme, dUTP pyrophosphatase, from Mycobacterium tuberculosis. Drugs targeted to this enzyme might inhibit the replication of the bacterium that causes most cases of tuberculosis. Mycobacterium Tuberculosis Center, PSI View Media
Natcher Building 03
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NIGMS staff are located in the Natcher Building on the NIH campus. Alisa Machalek, National Institute of General Medical Sciences View Media
Group of Culex quinquefasciatus mosquito larvae
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Mosquito larvae with genes edited by CRISPR. Valentino Gantz, University of California, San Diego. View Media
Electrode probe on mouse Huntington's muscle cell
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Using an electrode, researchers apply an electrical pulse onto a piece of muscle tissue affected by Huntington's disease. Grigor Varuzhanyan and Andrew A. Voss, California State Polytechnic University View Media
Bacterial cells aggregating above the light organ of the Hawaiian bobtail squid
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A light organ (~0.5 mm across) of a juvenile Hawaiian bobtail squid, Euprymna scolopes. Margaret J. McFall-Ngai, Carnegie Institution for Science/California Institute of Technology, and Edward G. Ruby, California Institute of Technology. View Media
Cryo-electron microscopy revealing the "wasabi receptor"
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The TRPA1 protein is responsible for the burn you feel when you taste a bite of sushi topped with wasabi. Jean-Paul Armache, UCSF View Media
Epigenetic code (with labels)
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The "epigenetic code" controls gene activity with chemical tags that mark DNA (purple diamonds) and the "tails" of histone proteins (purple triangles). Crabtree + Company View Media
Antitoxin GhoS (Illustration 2)
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Structure of the bacterial antitoxin protein GhoS. GhoS inhibits the production of a bacterial toxin, GhoT, which can contribute to antibiotic resistance. Rebecca Page and Wolfgang Peti, Brown University and Thomas K. Wood, Pennsylvania State University View Media
Wound healing in process
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Wound healing requires the action of stem cells. Hermann Steller, Rockefeller University View Media
Wild-type and mutant fruit fly ovaries
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The two large, central, round shapes are ovaries from a typical fruit fly (Drosophila melanogaster). Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View Media
Time-lapse video of floral pattern in a mixture of two bacterial species, Acinetobacter baylyi and Escherichia coli, grown on a semi-solid agar for 24 hours
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This time-lapse video shows the emergence of a flower-like pattern in a mixture of two bacterial species, motile Acinetobacter baylyi and non-motile Escherichia coli (green), that are gr L. Xiong et al, eLife 2020;9: e48885 View Media
Dense tubular matrices in the peripheral endoplasmic reticulum (ER) 2
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Three-dimensional reconstruction of a tubular matrix in a thin section of the peripheral endoplasmic reticulum between the plasma membranes of the cell. Jennifer Lippincott-Schwartz, Howard Hughes Medical Institute Janelia Research Campus, Virginia View Media
Assembly of the HIV capsid
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The HIV capsid is a pear-shaped structure that is made of proteins the virus needs to mature and become infective. John Grime and Gregory Voth, The University of Chicago View Media
Nucleolus subcompartments spontaneously self-assemble 4
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What looks a little like distant planets with some mysterious surface features are actually assemblies of proteins normally found in the cell's nucleolus, a small but very important protein complex lo Nilesh Vaidya, Princeton University View Media
Tracking embryonic zebrafish cells
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To better understand cell movements in developing embryos, researchers isolated cells from early zebrafish embryos and grew them as clusters. Liliana Solnica-Krezel, Washington University School of Medicine in St. Louis. View Media
Mouse brain slice showing nerve cells
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A 20-µm thick section of mouse midbrain. The nerve cells are transparent and weren’t stained. Michael Shribak, Marine Biological Laboratory/University of Chicago. View Media
Kinases
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Kinases are enzymes that add phosphate groups (red-yellow structures) to proteins (green), assigning the proteins a code. Crabtree + Company View Media
PSI: from genes to structures
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The goal of the Protein Structure Initiative (PSI) is to determine the three-dimensional shapes of a wide range of proteins by solving the structures of representative members of each protein family f National Institute of General Medical Sciences View Media
Pig trypsin crystal
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A crystal of pig trypsin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Isolated Planarian Pharynx
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The feeding tube, or pharynx, of a planarian worm with cilia shown in red and muscle fibers shown in green View Media
