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Nicotinic acid phosphoribosyltransferase
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Model of the enzyme nicotinic acid phosphoribosyltransferase. Berkeley Structural Genomics Center, PSI View Media
Space-filling model of a cefotaxime-CCD-1 complex
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CCD-1 is an enzyme produced by the bacterium Clostridioides difficile that helps it resist antibiotics. Keith Hodgson, Stanford University. View Media
Bence Jones protein MLE
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A crystal of Bence Jones protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Dopaminergic neurons from ES cells
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Human embryonic stem cells differentiated into dopaminergic neurons, the type that degenerate in Parkinson's disease. Image courtesy of the California Institute for Regenerative Medicine. Jeannie Liu, Lab of Jan Nolta, University of California, Davis, via CIRM View Media
Cells frozen in time
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The fledgling field of X-ray microscopy lets researchers look inside whole cells rapidly frozen to capture their actions at that very moment. Here, a yeast cell buds before dividing into two. Carolyn Larabell, University of California, San Francisco, and the Lawrence Berkeley National Laboratory View Media
Sphingolipid S1P1 receptor
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The receptor is shown bound to an antagonist, ML056. Raymond Stevens, The Scripps Research Institute View Media
Cell division and cell death
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Two cells over a 2-hour period. The one on the bottom left goes through programmed cell death, also known as apoptosis. The one on the top right goes through cell division, also called mitosis. Dylan T. Burnette, Vanderbilt University School of Medicine. View Media
Developing Arabidopsis flower buds
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Flower development is a carefully orchestrated, genetically programmed process that ensures that the male (stamen) and female (pistil) organs form in the right place and at the right time in the flowe Nathanaël Prunet, Caltech View Media
Fruit fly nurse cells during egg development
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In many animals, the egg cell develops alongside sister cells. Adam C. Martin, Massachusetts Institute of Technology. View Media
Disrupted and restored vasculature development in frog embryos
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Disassembly of vasculature and reassembly after addition and then washout of 250 µM TBZ in kdr:GFP frogs. Hye Ji Cha, University of Texas at Austin View Media
Glowing fish
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Professor Marc Zimmer's family pets, including these fish, glow in the dark in response to blue light. Featured in the September 2009 issue of Findings. View Media
Bovine milk alpha-lactalbumin (1)
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A crystal of bovine milk alpha-lactalbumin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Confocal microscopy of perineuronal nets in the brain 1
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The photo shows a confocal microscopy image of perineuronal nets (PNNs), which are specialized extracellular matrix (ECM) structures in the brain. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Cell division with late aligning chromosomes
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This video shows an instance of abnormal mitosis where chromosomes are late to align. Gary Gorbsky, Oklahoma Medical Research Foundation View Media
Soft X-ray tomography of a pancreatic beta cell
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A color-coded, 3D model of a rat pancreatic β cell. This type of cell produces insulin, a hormone that helps regulate blood sugar. Carolyn Larabell, University of California, San Francisco. View Media
Glow-in-the-dark salamanders
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These six-month-old axolotls, a kind of salamander, glow green and blue under ultraviolet light. That's because they were genetically modified to make harmless green fluorescent protein, or GFP. View Media
Cryo-ET cell cross-section visualizing insulin vesicles
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On the left, a cross-section slice of a rat pancreas cell captured using cryo-electron tomography (cryo-ET). On the right, a color-coded, 3D version of the image highlighting cell structures. Xianjun Zhang, University of Southern California. View Media
NMR spectrometer
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This photo shows a Varian Unity Inova 900 MHz, 21.1 T standard bore magnet Nuclear Magnetic Resonnance (NMR) spectrometer. Center for Eukaryotic Structural Genomics View Media
Worms and human infertility
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This montage of tiny, transparent C. elegans--or roundworms--may offer insight into understanding human infertility. Abby Dernburg, Lawrence Berkeley National Laboratory View Media
An insect tracheal cell delivers air to muscles
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Insects like the fruit fly use an elaborate network of branching tubes called trachea (green) to transport oxygen throughout their bodies. Jayan Nair and Maria Leptin, European Molecular Biology Laboratory, Heidelberg, Germany View Media
G switch (with labels)
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The G switch allows our bodies to respond rapidly to hormones. G proteins act like relay batons to pass messages from circulating hormones into cells. Crabtree + Company View Media
Electrode probe on mouse Huntington's muscle cell
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Using an electrode, researchers apply an electrical pulse onto a piece of muscle tissue affected by Huntington's disease. Grigor Varuzhanyan and Andrew A. Voss, California State Polytechnic University View Media
Stem cell differentiation
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Undifferentiated embryonic stem cells cease to exist a few days after conception. In this image, ES cells are shown to differentiate into sperm, muscle fiber, hair cells, nerve cells, and cone cells. Judith Stoffer View Media
Phenylalanine tRNA molecule
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Phenylalanine tRNA showing the anticodon (yellow) and the amino acid, phenylalanine (blue and red spheres). Patrick O'Donoghue and Dieter Soll, Yale University View Media
Dicty fruit
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Dictyostelium discoideum is a microscopic amoeba. A group of 100,000 form a mound as big as a grain of sand. Featured in The New Genetics. View Media
Cytonemes in developing fruit fly cells
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Scientists have long known that multicellular organisms use biological molecules produced by one cell and sensed by another to transmit messages that, for instance, guide proper development of organs Sougata Roy, University of California, San Francisco View Media
Sheep hemoglobin crystal
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A crystal of sheep hemoglobin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View Media
Protein formation
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Proteins are 3D structures made up of smaller units. DNA is transcribed to RNA, which in turn is translated into amino acids. NIGMS, with the folded protein illustration adapted from Jane Richardson, Duke University Medical Center View Media
Mitosis and meiosis compared-labeled
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Meiosis is used to make sperm and egg cells. During meiosis, a cell's chromosomes are copied once, but the cell divides twice. Judith Stoffer View Media
Yeast cells responding to a glucose shortage
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These yeast cells were exposed to a glucose (sugar) shortage. Mike Henne, University of Texas Southwestern Medical Center. View Media
X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor 6
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X-ray co-crystal structure of Src kinase bound to a DNA-templated macrocycle inhibitor. Markus A. Seeliger, Stony Brook University Medical School and David R. Liu, Harvard University View Media
Biosensors illustration
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A rendering of an activity biosensor image overlaid with a cell-centered frame of reference used for image analysis of signal transduction. Gaudenz Danuser, Harvard Medical School View Media
Anthrax bacteria (green) being swallowed by an immune system cell
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Multiple anthrax bacteria (green) being enveloped by an immune system cell (purple). Anthrax bacteria live in soil and form dormant spores that can survive for decades. Camenzind G. Robinson, Sarah Guilman, and Arthur Friedlander, United States Army Medical Research Institute of Infectious Diseases View Media
Neural circuits in worms similar to those in humans
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Green and yellow fluorescence mark the processes and cell bodies of some C. elegans neurons. Shawn Xu, University of Michigan View Media
Plant resistosome
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The research organism Arabidopsis thaliana forms a large molecular machine called a resistosome to fight off infections. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Trajectories of labeled cell receptors
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Trajectories of single molecule labeled cell surface receptors. This is an example of NIH-supported research on single-cell analysis. Gaudenz Danuser, Harvard Medical School View Media
Superconducting magnet
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Superconducting magnet for NMR research, from the February 2003 profile of Dorothee Kern in Findings. Mike Lovett View Media
Dense tubular matrices in the peripheral endoplasmic reticulum (ER) 2
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Three-dimensional reconstruction of a tubular matrix in a thin section of the peripheral endoplasmic reticulum between the plasma membranes of the cell. Jennifer Lippincott-Schwartz, Howard Hughes Medical Institute Janelia Research Campus, Virginia View Media
Magnesium transporter protein from E. faecalis
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Structure of a magnesium transporter protein from an antibiotic-resistant bacterium (Enterococcus faecalis) found in the human gut. New York Structural GenomiX Consortium View Media
Neuron with labeled synapses
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In this image, recombinant probes known as FingRs (Fibronectin Intrabodies Generated by mRNA display) were expressed in a cortical neuron, where they attached fluorescent proteins to either PSD95 (gre Don Arnold and Richard Roberts, University of Southern California. View Media
Anti-tumor drug ecteinascidin 743 (ET-743), structure without hydrogens 03
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Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, Ecteinascidia turbinata, by NIGMS grantee Kenneth Rinehart at the University of Illinois. Timothy Jamison, Massachusetts Institute of Technology View Media
Mitosis and meiosis compared
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Meiosis is used to make sperm and egg cells. During meiosis, a cell's chromosomes are copied once, but the cell divides twice. Judith Stoffer View Media
Four timepoints in gastrulation
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It has been said that gastrulation is the most important event in a person's life. Bob Goldstein, University of North Carolina, Chapel Hill View Media
Brains of sleep-deprived and well-rested fruit flies
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On top, the brain of a sleep-deprived fly glows orange because of Bruchpilot, a communication protein between brain cells. These bright orange brain areas are associated with learning. Chiara Cirelli, University of Wisconsin-Madison View Media
Structure of a key antigen protein involved with Hepatitis C Virus infection
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A three-dimensional representation of the structure of E2, a key antigen protein involved with hepatitis C virus infection. Mansun Law Associate Professor Department of Immunolgy and Microbial Science The Scripps Research Institute View Media
Histones in chromatin (with labels)
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Histone proteins loop together with double-stranded DNA to form a structure that resembles beads on a string. Crabtree + Company View Media
Precisely Delivering Chemical Cargo to Cells
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Moving protein or other molecules to specific cells to treat or examine them has been a major biological challenge. Nature Nanotechnology View Media
Larvae from the parasitic worm that causes schistosomiasis
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The parasitic worm that causes schistosomiasis hatches in water and grows up in a freshwater snail, as shown here. Bo Wang and Phillip A. Newmark, University of Illinois at Urbana-Champaign, 2013 FASEB BioArt winner View Media
