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Recombinant DNA
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To splice a human gene into a plasmid, scientists take the plasmid out of an E. coli bacterium, cut the plasmid with a restriction enzyme, and splice in human DNA. Crabtree + Company View MediaBiofilm formed by a pathogen
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A biofilm is a highly organized community of microorganisms that develops naturally on certain surfaces. Scott Chimileski, Ph.D., and Roberto Kolter, Ph.D., Harvard Medical School. View MediaMouse heart muscle cells 02
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This image shows neonatal mouse heart cells. These cells were grown in the lab on a chip that aligns the cells in a way that mimics what is normally seen in the body. Kara McCloskey lab, University of California, Merced, via CIRM View MediaOlfactory system
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Sensory organs have cells equipped for detecting signals from the environment, such as odors. Judith Stoffer View MediaMitosis and meiosis compared-labeled
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Meiosis is used to make sperm and egg cells. During meiosis, a cell's chromosomes are copied once, but the cell divides twice. Judith Stoffer View MediaAxolotl
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An axolotl—a type of salamander—that has been genetically modified so that its developing nervous system glows purple and its Schwann cell nuclei appear light blue. Prayag Murawala, MDI Biological Laboratory and Hannover Medical School. View MediaFruit fly ovary
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A fruit fly ovary, shown here, contains as many as 20 eggs. Fruit flies are not merely tiny insects that buzz around overripe fruit—they are a venerable scientific tool. Denise Montell, Johns Hopkins University and University of California, Santa Barbara View MediaBovine milk alpha-lactalbumin (2)
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Crystals of bovine milk alpha-lactalbumin protein created for X-ray crystallography, which can reveal detailed, three-dimensional protein structures. Alex McPherson, University of California, Irvine View MediaHeLa cells
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Multiphoton fluorescence image of cultured HeLa cells with a fluorescent protein targeted to the Golgi apparatus (orange), microtubules (green) and counterstained for DNA (cyan). National Center for Microscopy and Imaging Research (NCMIR) View MediaSpace-filling model of a cefotaxime-CCD-1 complex
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CCD-1 is an enzyme produced by the bacterium Clostridioides difficile that helps it resist antibiotics. Keith Hodgson, Stanford University. View MediaFocal adhesions (with labels)
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Cells walk along body surfaces via tiny "feet," called focal adhesions, that connect with the extracellular matrix. Crabtree + Company View MediaKluyveromyces polysporus Argonaute bound to guide RNA
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A segment of siRNA, shown in red, guides a "slicer" protein called Argonaute (multi-colored twists and corkscrews) to the target RNA molecules. Kotaro Nakanishi and David Weinberg, Massachusetts Institute of Technology View MediaFruit fly nurse cells transporting their contents during egg development
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In many animals, the egg cell develops alongside sister cells. Adam C. Martin, Massachusetts Institute of Technology. View MediaDying melanoma cells
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Melanoma (skin cancer) cells undergoing programmed cell death, also called apoptosis. This process was triggered by raising the pH of the medium that the cells were growing in. Dylan T. Burnette, Vanderbilt University School of Medicine. View MediaGroup of fluorescent C. elegans showing muscle and ribosomal protein
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Three C. elegans, tiny roundworms, with a ribosomal protein glowing red and muscle fibers glowing green. Researchers used these worms to study a molecular pathway that affects aging. Jarod Rollins, Mount Desert Island Biological Laboratory. View MediaHsp33 figure 1
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Featured in the March 15, 2012 issue of Biomedical Beat. Related to Hsp33 Figure 2, image 3355. Ursula Jakob and Dana Reichmann, University of Michigan View MediaA panorama view of cells
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This photograph shows a panoramic view of HeLa cells, a cell line many researchers use to study a large variety of important research questions. Tom Deerinck, National Center for Microscopy and Imaging Research View MediaTelomerase illustration
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Reactivating telomerase in our cells does not appear to be a good way to extend the human lifespan. Cancer cells reactivate telomerase. Judith Stoffer View MediaFruit fly egg chamber
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A fruit fly (Drosophila melanogaster) egg chamber with microtubules shown in green and actin filaments shown in red. Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View MediaCalling Cards in a mouse brain
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The green spots in this mouse brain are cells labeled with Calling Cards, a technology that records molecular events in brain cells as they mature. Allen Yen, Lab of Joseph Dougherty, Washington University School of Medicine in St. Louis. View MediaActivated mast cell surface
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A scanning electron microscope image of an activated mast cell. This image illustrates the interesting topography of the cell membrane, which is populated with receptors. Bridget Wilson, University of New Mexico View MediaCells frozen in time
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The fledgling field of X-ray microscopy lets researchers look inside whole cells rapidly frozen to capture their actions at that very moment. Here, a yeast cell buds before dividing into two. Carolyn Larabell, University of California, San Francisco, and the Lawrence Berkeley National Laboratory View MediaMouse colon with gut bacteria
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A section of mouse colon with gut bacteria (center, in green) residing within a protective pocket. Sarkis K. Mazmanian, California Institute of Technology View MediaStaphylococcus aureus aggregates on microstructured titanium surface
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Groups of Staphylococcus aureus bacteria (blue) attached to a microstructured titanium surface (green) that mimics an orthopedic implant used in joint replacement. Paul Stoodley, The Ohio State University. View MediaBone cancer cell
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This image shows an osteosarcoma cell with DNA in blue, energy factories (mitochondria) in yellow, and actin filaments—part of the cellular skeleton—in purple. Dylan Burnette and Jennifer Lippincott-Schwartz, NICHD View MediaComputer model of cell membrane
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A computer model of the cell membrane, where the plasma membrane is red, endoplasmic reticulum is yellow, and mitochondria are blue. Bridget Wilson, University of New Mexico View MediaVDAC-1 (4)
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The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View MediaX-ray crystallography
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X-ray crystallography allows researchers to see structures too small to be seen by even the most powerful microscopes. Crabtree + Company View MediaMapping human genetic variation
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This map paints a colorful portrait of human genetic variation around the world. Noah Rosenberg and Martin Soave, University of Michigan View MediaAnimal cell
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A typical animal cell, sliced open to reveal a cross-section of organelles. Judith Stoffer View MediaFruit fly larvae brains showing tubulin
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Two fruit fly (Drosophila melanogaster) larvae brains with neurons expressing fluorescently tagged tubulin protein. Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View MediaYeast art depicting the New York City skyline
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This skyline of New York City was created by “printing” nanodroplets containing yeast (Saccharomyces cerevisiae) onto a large plate. Each dot is a separate yeast colony. Michael Shen, Ph.D., Jasmine Temple, Leslie Mitchell, Ph.D., and Jef Boeke, Ph.D., New York University School of Medicine; and Nick Phillips, James Chuang, Ph.D., and Jiarui Wang, Johns Hopkins University. View MediaMitochondria from rat heart muscle cell_2
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These mitochondria (brown) are from the heart muscle cell of a rat. Mitochondria have an inner membrane that folds in many places (and that appears here as striations). National Center for Microscopy and Imaging Research View Media¿Qué es la sepsis? (Sepsis Infographic)
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La sepsis o septicemia es la respuesta fulminante y extrema del cuerpo a una infección. En los Estados Unidos, más de 1.7 millones de personas contraen sepsis cada año. Instituto Nacional de Ciencias Médicas Generales View MediaBioluminescent imaging in adult zebrafish - lateral and overhead view
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Luciferase-based imaging enables visualization and quantification of internal organs and transplanted cells in live adult zebrafish. Kenneth Poss, Duke University View MediaZebrafish larva
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You are face to face with a 6-day-old zebrafish larva. What look like eyes will become nostrils, and the bulges on either side will become eyes. Oscar Ruiz and George Eisenhoffer, University of Texas MD Anderson Cancer Center, Houston View MediaCaulobacter
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A study using Caulobacter crescentus showed that some bacteria use just-in-time processing, much like that used in industrial delivery, to make the glue that allows them to attach to surfaces, Yves Brun, Indiana University View MediaChromatin in human tenocyte
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The nucleus of a degenerating human tendon cell, also known as a tenocyte. It has been color-coded based on the density of chromatin—a substance made up of DNA and proteins. Melike Lakadamyali, Perelman School of Medicine at the University of Pennsylvania. View MediaMeasles virus proteins
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A cross section of the measles virus in which six proteins (enlarged on the outside of the virus) work together to infect cells. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View MediaZika virus
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Zika virus is shown in cross section at center left. On the outside, it includes envelope protein (red) and membrane protein (magenta) embedded in a lipid membrane (light purple). Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View MediaSalivary gland in the developing fruit fly
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For fruit flies, the salivary gland is used to secrete materials for making the pupal case, the protective enclosure in which a larva transforms into an adult fly. Richard Fehon, University of Chicago View MediaVDAC-1 (3)
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The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View MediaRibonuclease P structure
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Ribbon diagram showing the structure of Ribonuclease P with tRNA. PDB entry 3Q1Q, molecular modeling by Fred Friedman, NIGMS View MediaPanC from M. tuberculosis
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Model of an enzyme, PanC, that is involved in the last step of vitamin B5 biosynthesis in Mycobacterium tuberculosis. PanC is essential for the growth of M. Mycobacterium Tuberculosis Center, PSI View MediaTonB protein in gram-negative bacteria
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The green in this image highlights a protein called TonB, which is produced by many gram-negative bacteria, including those that cause typhoid fever, meningitis and dysentery. Phillip Klebba, Kansas State University View MediaMicrosporidia in roundworm 2
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Many disease-causing microbes manipulate their host’s metabolism and cells for their own ends. Keir Balla and Emily Troemel, University of California San Diego View MediaCytoscape network diagram 1
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Molecular biologists are increasingly relying on bioinformatics software to visualize molecular interaction networks and to integrate these networks with data such as gene expression profiles. Keiichiro Ono, Trey Ideker lab, University of California, San Diego View MediaMaster clock of the mouse brain
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An image of the area of the mouse brain that serves as the 'master clock,' which houses the brain's time-keeping neurons. The nuclei of the clock cells are shown in blue. Erik Herzog, Washington University in St. Louis View MediaXenopus laevis egg
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Xenopus laevis, the African clawed frog, has long been used as a model organism for studying embryonic development. Michael Klymkowsky, University of Colorado, Boulder View Media