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Four timepoints in gastrulation
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It has been said that gastrulation is the most important event in a person's life. Bob Goldstein, University of North Carolina, Chapel Hill View Media
Fused, dicentric chromosomes
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This fused chromosome has two functional centromeres, shown as two sets of red and green dots. Beth A. Sullivan, Duke University View Media
Wild-type and mutant fruit fly ovaries
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The two large, central, round shapes are ovaries from a typical fruit fly (Drosophila melanogaster). Vladimir I. Gelfand, Feinberg School of Medicine, Northwestern University. View Media
Lily mitosis 04
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A light microscope image of a cell from the endosperm of an African globe lily (Scadoxus katherinae). This is one frame of a time-lapse sequence that shows cell division in action. Andrew S. Bajer, University of Oregon, Eugene View Media
Haplotypes (with labels)
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Haplotypes are combinations of gene variants that are likely to be inherited together within the same chromosomal region. Crabtree + Company View Media
Borrelia burgdorferi
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Borrelia burgdorferi is a spirochete, a class of long, slender bacteria that typically take on a coiled shape. Infection with this bacterium causes Lyme disease. Tina Weatherby Carvalho, University of Hawaii at Manoa View Media
Small blood vessels in a mouse retina
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Blood vessels at the back of the eye (retina) are used to diagnose glaucoma and diabetic eye disease. They also display characteristic changes in people with high blood pressure. National Center for Microscopy and Imaging Research View Media
Spreading Cells- 02
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Cells move forward with lamellipodia and filopodia supported by networks and bundles of actin filaments. Proper, controlled cell movement is a complex process. Rong Li and Praveen Suraneni, Stowers Institute for Medical Research View Media
Telomeres on outer edge of nucleus during cell division
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New research shows telomeres moving to the outer edge of the nucleus after cell division, suggesting these caps that protect chromosomes also may play a role in organizing DNA. Laure Crabbe, Jamie Kasuboski and James Fitzpatrick, Salk Institute for Biological Studies View Media
iPS cell facility at the Coriell Institute for Medical Research
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This lab space was designed for work on the induced pluripotent stem (iPS) cell collection, part of the NIGMS Human Genetic Cell Repository at the Coriell Institute for Medical Research. Courtney Sill, Coriell Institute for Medical Research View Media
Suicidal Stem Cells
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Embryonic stem cells store pre-activated Bax (red) in the Golgi, near the nucleus (blue). Featured in the June 21, 2012, issue of Biomedical Beat. Mohanish Deshmukh View Media
Glycoproteins
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About half of all human proteins include chains of sugar molecules that are critical for the proteins to function properly. Appears in the NIGMS booklet Inside the Cell. Judith Stoffer View Media
Dopaminergic neurons from ES cells
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Human embryonic stem cells differentiated into dopaminergic neurons, the type that degenerate in Parkinson's disease. Image courtesy of the California Institute for Regenerative Medicine. Jeannie Liu, Lab of Jan Nolta, University of California, Davis, via CIRM View Media
Antibiotic-surviving bacteria
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Colonies of bacteria growing despite high concentrations of antibiotics. These colonies are visible both by eye, as seen on the left, and by bioluminescence imaging, as seen on the right. Paul Stoodley, The Ohio State University. View Media
Lily mitosis 05
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A light microscope image of a cell from the endosperm of an African globe lily (Scadoxus katherinae). This is one frame of a time-lapse sequence that shows cell division in action. Andrew S. Bajer, University of Oregon, Eugene View Media
Snowflake yeast 1
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Multicellular yeast called snowflake yeast that researchers created through many generations of directed evolution from unicellular yeast. William Ratcliff, Georgia Institute of Technology. View Media
Fibroblasts with nuclei in blue, energy factories in green and the actin cytoskeleton in red
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The cells shown here are fibroblasts, one of the most common cells in mammalian connective tissue. These particular cells were taken from a mouse embryo. Dylan Burnette, NICHD View Media
Microsporidia in roundworm 2
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Many disease-causing microbes manipulate their host’s metabolism and cells for their own ends. Keir Balla and Emily Troemel, University of California San Diego View Media
How a microtubule builds and deconstructs
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A microtubule, part of the cell's skeleton, builds and deconstructs. View Media
Scanning electron microscopy of the ECM on the surface of a calf muscle
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This image shows the extracellular matrix (ECM) on the surface of a soleus (lower calf) muscle in light brown and blood vessels in pink. Tom Deerinck, National Center for Microscopy and Imaging Research (NCMIR) View Media
Math from the heart
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Watch a cell ripple toward a beam of light that turns on a movement-related protein. View Media
Plastic-eating enzymes
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PETase enzyme degrades polyester plastic (polyethylene terephthalate, or PET) into monohydroxyethyl terephthalate (MHET). Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Peripheral nerve cells derived from ES cells
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Peripheral nerve cells made from human embryonic stem cell-derived neural crest stem cells. Stephen Dalton, University of Georgia View Media
DDR2 Receptors Attach to Collagen in Breast Tumor
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On the left, the boundary of a breast tumor (yellow) attaches to collagen fibers that are closest to it (green) using DDR2. On the right, a tumor without DDR2 remains disconnected from the collagen. Callie Corsa and Suzanne Ponik, Washington University School of Medicine in St. Louis View Media
“Two-faced” Janus particle activating a macrophage
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A macrophage—a type of immune cell that engulfs invaders—“eats” and is activated by a “two-faced” Janus particle. Yan Yu, Indiana University, Bloomington. View Media
Hydra 05
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Hydra magnipapillata is an invertebrate animal used as a model organism to study developmental questions, for example the formation of the body axis. Hiroshi Shimizu, National Institute of Genetics in Mishima, Japan View Media
H1 histamine receptor
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The receptor is shown bound to an inverse agonist, doxepin. Raymond Stevens, The Scripps Research Institute View Media
Mouse mammary cells lacking anti-cancer protein
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Shortly after a pregnant woman gives birth, her breasts start to secrete milk. This process is triggered by hormonal and genetic cues, including the protein Elf5. Nature Cell Biology, November 2012, Volume 14 No 11 pp1113-1231 View Media
Introns (with labels)
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Genes are often interrupted by stretches of DNA (introns, blue) that do not contain instructions for making a protein. Crabtree + Company View Media
Wound healing in process
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Wound healing requires the action of stem cells. Hermann Steller, Rockefeller University View Media
Mitosis - telophase
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Telophase during mitosis: Nuclear membranes form around each of the two sets of chromosomes, the chromosomes begin to spread out, and the spindle begins to break down. Judith Stoffer View Media
Draper, shown in the fatbody of a Drosophila melanogaster larva
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The fly fatbody is a nutrient storage and mobilization organ akin to the mammalian liver. The engulfment receptor Draper (green) is located at the cell surface of fatbody cells. Christina McPhee and Eric Baehrecke, University of Massachusetts Medical School View Media
SARS-CoV-2 nucleocapsid dimer
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In SARS-CoV-2, the virus that causes COVID-19, nucleocapsid is a complex molecule with many functional parts. Amy Wu and Christine Zardecki, RCSB Protein Data Bank. View Media
Quartered torso
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Cells function within organs and tissues, such as the lungs, heart, intestines, and kidney. Judith Stoffer View Media
VDAC-1 (3)
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The structure of the pore-forming protein VDAC-1 from humans. Gerhard Wagner, Harvard Medical School View Media
From DNA to Protein (labeled)
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The genetic code in DNA is transcribed into RNA, which is translated into proteins with specific sequences. Crabtree + Company View Media
RNA interference (with labels)
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RNA interference or RNAi is a gene-silencing process in which double-stranded RNAs trigger the destruction of specific RNAs. Crabtree + Company View Media
Mitochondrion from insect flight muscle
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This is a tomographic reconstruction of a mitochondrion from an insect flight muscle. National Center for Microscopy and Imaging Research View Media
Active Site of E. coli response regulator PhoB
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Active site of E. coli response regulator PhoB. Ann Stock, Rutgers University View Media
Ear hair cells derived from embryonic stem cells
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Mouse embryonic stem cells matured into this bundle of hair cells similar to the ones that transmit sound in the ear. Stefen Heller, Stanford University, via CIRM View Media
Independence Day
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This graphic that resembles a firework was created from a picture of a fruit fly spermatid. Sigi Benjamin-Hong, Rockefeller University View Media
Structure of a key antigen protein involved with Hepatitis C Virus infection
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A three-dimensional representation of the structure of E2, a key antigen protein involved with hepatitis C virus infection. Mansun Law Associate Professor Department of Immunolgy and Microbial Science The Scripps Research Institute View Media
Fruit fly spermatids
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Developing spermatids (precursors of mature sperm cells) begin as small, round cells and mature into long-tailed, tadpole-shaped ones. Lacramioara Fabian, The Hospital for Sick Children, Toronto, Canada View Media
Superconducting magnet
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Superconducting magnet for NMR research, from the February 2003 profile of Dorothee Kern in Findings. Mike Lovett View Media
Genetically identical mycobacteria respond differently to antibiotic 2
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Antibiotic resistance in microbes is a serious health concern. So researchers have turned their attention to how bacteria undo the action of some antibiotics. Bree Aldridge, Tufts University View Media
¿Qué es la sepsis? (Sepsis Infographic)
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La sepsis o septicemia es la respuesta fulminante y extrema del cuerpo a una infección. En los Estados Unidos, más de 1.7 millones de personas contraen sepsis cada año. Instituto Nacional de Ciencias Médicas Generales View Media
Self-organizing proteins
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Under the microscope, an E. coli cell lights up like a fireball. Each bright dot marks a surface protein that tells the bacteria to move toward or away from nearby food and toxins. View Media
Anti-tumor drug ecteinascidin 743 (ET-743) with hydrogens 03
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Ecteinascidin 743 (ET-743, brand name Yondelis), was discovered and isolated from a sea squirt, Ecteinascidia turbinata, by NIGMS grantee Kenneth Rinehart at the University of Illinois. Timothy Jamison, Massachusetts Institute of Technology View Media
